Scnn1b (sodium channel epithelial 1 subunit beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Scnn1b (sodium channel epithelial 1 subunit beta) Heterocephalus glaber
Analyze
Symbol: Scnn1b
Name: sodium channel epithelial 1 subunit beta (Ensembl:sodium channel epithelial 1 beta subunit)
RGD ID: 18932270
Description: ENCODES a protein that exhibits ligand-gated sodium channel activity (ortholog); sodium channel activity (ortholog); sodium ion transmembrane transporter activity (ortholog); INVOLVED IN aldosterone metabolic process (ortholog); artery smooth muscle contraction (ortholog); cellular response to acidic pH (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH Adrenal Insufficiency (ortholog); autism spectrum disorder (ortholog); autosomal recessive pseudohypoaldosteronism type 1 (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: amiloride-sensitive sodium channel subunit beta; sodium channel epithelial 1 beta subunit; sodium channel, non-voltage-gated 1, beta subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,549,583 - 8,581,819 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247828,521,639 - 8,580,099 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Scnn1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,549,583 - 8,581,819 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247828,521,639 - 8,580,099 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SCNN1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,278,231 - 23,381,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1623,278,231 - 23,381,294 (+)EnsemblGRCh38hg38GRCh38
GRCh371623,313,623 - 23,392,615 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,221,092 - 23,300,121 (+)NCBINCBI36Build 36hg18NCBI36
Build 341623,221,140 - 23,300,117NCBI
Celera1622,091,376 - 22,169,881 (+)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1621,402,990 - 21,480,744 (+)NCBIHuRef
CHM1_11624,325,334 - 24,404,340 (+)NCBICHM1_1
T2T-CHM13v2.01623,554,125 - 23,657,344 (+)NCBIT2T-CHM13v2.0
Scnn1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,464,261 - 121,517,951 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,464,261 - 121,517,737 (+)EnsemblGRCm39 Ensembl
GRCm387121,865,038 - 121,918,728 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7121,865,038 - 121,918,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,008,625 - 129,062,030 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367121,656,259 - 121,709,664 (+)NCBIMGSCv36mm8
Celera7121,788,233 - 121,808,466 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.07NCBI
Scnn1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81185,861,326 - 185,915,717 (+)NCBIGRCr8
mRatBN7.21176,430,063 - 176,484,451 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,430,103 - 176,484,451 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1184,757,955 - 184,812,267 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01191,943,901 - 191,998,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,627,931 - 184,682,270 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01191,829,547 - 191,883,991 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1191,829,555 - 191,884,298 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01198,932,512 - 198,953,453 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,682,622 - 180,748,068 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11180,822,536 - 180,887,983 (+)NCBI
Celera1174,140,255 - 174,194,462 (+)NCBICelera
Cytogenetic Map1q36NCBI
Scnn1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554931,904,220 - 1,956,303 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554931,937,507 - 1,956,248 (+)NCBIChiLan1.0ChiLan1.0
SCNN1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21824,712,414 - 24,794,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11629,231,645 - 29,312,685 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01614,728,834 - 14,809,072 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11623,555,391 - 23,634,873 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1623,555,388 - 23,634,873 (+)Ensemblpanpan1.1panPan2
SCNN1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1622,439,643 - 22,481,349 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl622,439,643 - 22,481,349 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha624,003,147 - 24,044,601 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0622,579,419 - 22,621,104 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl622,579,419 - 22,621,104 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1622,383,826 - 22,425,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0622,286,935 - 22,328,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0622,681,830 - 22,723,544 (-)NCBIUU_Cfam_GSD_1.0
Scnn1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344119,923,171 - 119,968,392 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365018,020,316 - 8,065,332 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365018,021,090 - 8,065,245 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCNN1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,832,262 - 22,902,063 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1322,832,259 - 22,902,592 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.210271,050 - 337,906 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCNN1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,021,181 - 21,107,746 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,022,133 - 21,107,824 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660688,719,000 - 8,805,239 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000023153   ⟹   ENSHGLP00000022939
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247828,549,583 - 8,579,717 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000023154   ⟹   ENSHGLP00000022940
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247828,558,892 - 8,581,819 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000023155   ⟹   ENSHGLP00000022941
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247828,559,405 - 8,572,775 (+)Ensembl
RefSeq Acc Id: XM_004855940   ⟹   XP_004855997
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247828,521,640 - 8,580,099 (+)NCBI
RefSeq Acc Id: XM_004855941   ⟹   XP_004855998
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247828,549,623 - 8,580,099 (+)NCBI
RefSeq Acc Id: XM_021237315   ⟹   XP_021092974
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247828,521,639 - 8,580,099 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004855997 (Get FASTA)   NCBI Sequence Viewer  
  XP_004855998 (Get FASTA)   NCBI Sequence Viewer  
  XP_021092974 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022939
  ENSHGLP00000022940
GenBank Protein JAO01302 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021092974   ⟸   XM_021237315
- Peptide Label: isoform X2
- UniProtKB: G5BV76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004855997   ⟸   XM_004855940
- Peptide Label: isoform X1
- UniProtKB: A0A0N8EU79 (UniProtKB/TrEMBL),   G5BV76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004855998   ⟸   XM_004855941
- Peptide Label: isoform X1
- UniProtKB: A0A0N8EU79 (UniProtKB/TrEMBL),   G5BV76 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000022940   ⟸   ENSHGLT00000023154
Ensembl Acc Id: ENSHGLP00000022941   ⟸   ENSHGLT00000023155
Ensembl Acc Id: ENSHGLP00000022939   ⟸   ENSHGLT00000023153


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016364 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000023153 ENTREZGENE
  ENSHGLT00000023154 ENTREZGENE
Gene3D-CATH Acid-sensing ion channels like domains UniProtKB/TrEMBL
  YojJ-like UniProtKB/TrEMBL
InterPro ENaC UniProtKB/TrEMBL
  ENaC_chordates UniProtKB/TrEMBL
  ENaC_CS UniProtKB/TrEMBL
KEGG Report hgl:101717352 UniProtKB/TrEMBL
NCBI Gene Scnn1b ENTREZGENE
PANTHER AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT BETA UniProtKB/TrEMBL
  PTHR11690 UniProtKB/TrEMBL
Pfam ASC UniProtKB/TrEMBL
PRINTS AMINACHANNEL UniProtKB/TrEMBL
PROSITE ASC UniProtKB/TrEMBL
UniProt A0A0N8EU79 ENTREZGENE, UniProtKB/TrEMBL
  G5BV76 ENTREZGENE, UniProtKB/TrEMBL