Clcnka (chloride voltage-gated channel Ka) - Rat Genome Database

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Gene: Clcnka (chloride voltage-gated channel Ka) Heterocephalus glaber
Analyze
Symbol: Clcnka
Name: chloride voltage-gated channel Ka
RGD ID: 18934005
Description: ENCODES a protein that exhibits chloride channel activity (ortholog); identical protein binding (ortholog); voltage-gated monoatomic ion channel activity (ortholog); INVOLVED IN body fluid secretion (ortholog); kidney development (ortholog); regulation of body fluid levels (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH autosomal recessive nonsyndromic deafness (ortholog); Bartter disease type 3 (ortholog); Bartter disease type 4b (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Chloride channel protein ClC-Ka
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,202,579 - 2,212,337 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247642,202,438 - 2,212,185 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Clcnka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,202,579 - 2,212,337 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247642,202,438 - 2,212,185 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CLCNKA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,022,036 - 16,034,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,018,875 - 16,034,050 (+)EnsemblGRCh38hg38GRCh38
GRCh37116,348,531 - 16,360,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,221,073 - 16,233,132 (+)NCBINCBI36Build 36hg18NCBI36
Build 34116,094,415 - 16,105,850NCBI
Celera114,828,391 - 14,840,450 (+)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef114,867,532 - 14,879,195 (+)NCBIHuRef
CHM1_1116,146,987 - 16,159,046 (+)NCBICHM1_1
T2T-CHM13v2.0115,463,347 - 15,475,360 (+)NCBIT2T-CHM13v2.0
Clcnka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,111,922 - 141,126,017 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,111,921 - 141,126,035 (-)EnsemblGRCm39 Ensembl
GRCm384141,384,611 - 141,398,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,384,610 - 141,398,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv374140,940,526 - 140,954,621 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364139,138,024 - 139,141,158 (-)NCBIMGSCv36mm8
MGSCv364140,656,686 - 140,670,775 (-)NCBIMGSCv36mm8
Celera4143,203,482 - 143,215,208 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.94NCBI
Clcnka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,974,190 - 158,989,275 (-)NCBIGRCr8
mRatBN7.25153,691,208 - 153,706,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,691,209 - 153,706,148 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,378,149 - 156,393,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,151,434 - 158,166,379 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,140,613 - 158,155,555 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,931,497 - 159,946,483 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,931,511 - 159,946,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,651,964 - 163,667,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,274,377 - 160,290,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,284,564 - 160,300,557 (-)NCBI
Celera5152,055,371 - 152,067,986 (-)NCBICelera
Cytogenetic Map5q36NCBI
LOC100986591
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,887,107 - 210,901,016 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,135,593 - 210,147,698 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0115,159,362 - 15,171,376 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,152,022 - 16,163,777 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,152,022 - 16,163,777 (+)Ensemblpanpan1.1panPan2
Clcnka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,766,062 - 37,777,337 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364743,591,134 - 3,601,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCNK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1675,178,914 - 75,192,670 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000018186   ⟹   ENSHGLP00000018009
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247642,202,579 - 2,212,337 (+)Ensembl
RefSeq Acc Id: XM_004850358   ⟹   XP_004850415
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247642,202,438 - 2,212,185 (+)NCBI
RefSeq Acc Id: XM_021262864   ⟹   XP_021118523
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247642,202,501 - 2,212,185 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004850415 (Get FASTA)   NCBI Sequence Viewer  
  XP_021118523 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB12003 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000018009
GenBank Protein JAN99593 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004850415   ⟸   XM_004850358
- UniProtKB: G5BRU1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021118523   ⟸   XM_021262864
- UniProtKB: G5BRU1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000018009   ⟸   ENSHGLT00000018186


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012896 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000018186 ENTREZGENE
Gene3D-CATH 3.10.580.10 UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/TrEMBL
InterPro CBS_dom UniProtKB/TrEMBL
  CBS_dom_sf UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/TrEMBL
  Cl_channel-K UniProtKB/TrEMBL
KEGG Report hgl:101713590 UniProtKB/TrEMBL
NCBI Gene Clcnka ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN 2 UniProtKB/TrEMBL
  CHLORIDE CHANNEL PROTEIN CLC-KB UniProtKB/TrEMBL
Pfam CBS UniProtKB/TrEMBL
  Voltage_CLC UniProtKB/TrEMBL
PRINTS CLCHANNEL UniProtKB/TrEMBL
  CLCHANNELKDY UniProtKB/TrEMBL
PROSITE CBS UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/TrEMBL
  SSF81340 UniProtKB/TrEMBL
UniProt G5BRU1 ENTREZGENE, UniProtKB/TrEMBL