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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:presequence pathway of mitochondrial protein import
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Accession:PW:0002137 term browser browse the term
Definition:A classical pathway of mitochondrial protein import that delivers matrix resident and some of the inner membrane proteins. The precursor proteins are synthesized with an amino terminal peptide extension - the presequence. Translocase complexes, chaperones and processing enzymes cooperate in the process.


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presequence pathway of mitochondrial protein import term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNAJC19 DnaJ heat shock protein family (Hsp40) member C19 ISO RGD PMID:25542066 RGD:10412659 NCBI chr34:14,199,507...14,204,736
Ensembl chr34:14,199,675...14,204,687 		JBrowse link
G GRPEL1 GrpE like 1, mitochondrial ISO RGD PMID:25542066 RGD:10412659 NCBI chr 3:59,124,116...59,131,541
Ensembl chr 3:59,124,613...59,131,977 		JBrowse link
G GRPEL2 GrpE like 2, mitochondrial ISO RGD PMID:25542066 RGD:10412659 NCBI chr 4:59,603,384...59,614,491
Ensembl chr 4:59,590,167...59,614,584 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25542066 RGD:10412659 NCBI chr11:26,122,917...26,142,458
Ensembl chr11:26,121,499...26,142,434 		JBrowse link
G IMMP1L inner mitochondrial membrane peptidase subunit 1 ISO RGD PMID:22172993 RGD:10412669 NCBI chr18:35,880,278...35,963,128
Ensembl chr18:35,880,183...35,963,494 		JBrowse link
G IMMP2L inner mitochondrial membrane peptidase subunit 2 ISO RGD PMID:22172993 RGD:10412669 NCBI chr14:50,487,679...51,336,906 JBrowse link
G LOC486776 mitochondrial import inner membrane translocase subunit Tim23 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr28:1,767,224...1,800,922
Ensembl chr28:1,767,299...1,800,685 		JBrowse link
G MIPEP mitochondrial intermediate peptidase ISO RGD PMID:22172993 RGD:10412669 NCBI chr25:14,755,474...14,930,412
Ensembl chr25:14,753,596...14,930,369 		JBrowse link
G PAM16 presequence translocase associated motor 16 ISO RGD PMID:25542066 RGD:10412659 NCBI chr 6:37,040,484...37,047,708 JBrowse link
G PMPCA peptidase, mitochondrial processing subunit alpha ISO RGD PMID:22172993 RGD:10412669 NCBI chr 9:49,073,124...49,083,302
Ensembl chr 9:49,073,108...49,224,961 		JBrowse link
G PMPCB peptidase, mitochondrial processing subunit beta ISO RGD PMID:22172993 RGD:10412669 NCBI chr18:16,894,240...16,906,988
Ensembl chr18:16,894,276...16,906,979 		JBrowse link
G ROMO1 reactive oxygen species modulator 1 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr24:24,614,920...24,616,586
Ensembl chr24:24,615,197...24,616,582
Ensembl chr25:24,615,197...24,616,582 		JBrowse link
G TIMM17A translocase of inner mitochondrial membrane 17A ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr 7:1,002,710...1,015,803
Ensembl chr 7:1,003,236...1,015,694 		JBrowse link
G TIMM21 translocase of inner mitochondrial membrane 21 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr 1:5,175,702...5,182,096
Ensembl chr 1:5,175,714...5,181,883 		JBrowse link
G TIMM44 translocase of inner mitochondrial membrane 44 ISO RGD PMID:25542066 RGD:10412659 NCBI chr20:52,614,814...52,628,545
Ensembl chr20:52,615,040...52,628,471 		JBrowse link
G TIMM50 translocase of inner mitochondrial membrane 50 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr 1:113,749,778...113,758,480
Ensembl chr 1:113,749,994...113,757,930 		JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr 4:4,785,589...4,802,170
Ensembl chr 4:4,785,584...4,801,006 		JBrowse link
G TOMM22 translocase of outer mitochondrial membrane 22 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr10:26,116,635...26,118,692 JBrowse link
G TOMM40 translocase of outer mitochondrial membrane 40 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr 1:110,530,233...110,541,049
Ensembl chr 1:110,530,597...110,541,042 		JBrowse link
G TOMM5 translocase of outer mitochondrial membrane 5 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr11:53,896,300...53,901,523
Ensembl chr11:53,896,305...53,901,489 		JBrowse link
G TOMM6 translocase of outer mitochondrial membrane 6 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr12:10,473,592...10,484,374
Ensembl chr12:10,473,592...10,474,864 		JBrowse link
G TOMM7 translocase of outer mitochondrial membrane 7 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr14:36,523,707...36,532,180
Ensembl chr14:36,523,707...36,532,291 		JBrowse link
G TOMM70 translocase of outer mitochondrial membrane 70 ISO RGD PMID:25542066 PMID:25633533 RGD:10412658 RGD:10412659 NCBI chr33:6,976,322...7,009,618
Ensembl chr33:6,976,934...7,009,594 		JBrowse link
G XPNPEP3 X-prolyl aminopeptidase 3 ISO RGD PMID:22172993 RGD:10412669 NCBI chr10:24,304,342...24,379,562
Ensembl chr10:24,307,091...24,379,448 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4046
    regulatory pathway 2499
      homeostasis pathway 1305
        mitochondria homeostasis pathway 112
          mitochondrial protein import pathway 43
            presequence pathway of mitochondrial protein import 24
paths to the root