TIMM21 (translocase of inner mitochondrial membrane 21) - Rat Genome Database

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Gene: TIMM21 (translocase of inner mitochondrial membrane 21) Canis lupus familiaris
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Symbol: TIMM21
Name: translocase of inner mitochondrial membrane 21
RGD ID: 12212676
Description: INVOLVED IN mitochondrial cytochrome c oxidase assembly (inferred); mitochondrial respiratory chain complex I assembly (inferred); protein import into mitochondrial matrix (inferred); PARTICIPATES IN presequence pathway of mitochondrial protein import; ASSOCIATED WITH chromosome 18q deletion syndrome (ortholog); genetic disease (ortholog); intestinal volvulus (ortholog); FOUND IN mitochondrial inner membrane (inferred); mitochondrion (inferred); TIM23 mitochondrial import inner membrane translocase complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C1H18orf55; mitochondrial import inner membrane translocase subunit Tim21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115,175,702 - 5,182,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15,175,714 - 5,181,883 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha16,182,962 - 6,189,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014,986,113 - 4,992,490 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14,986,115 - 4,992,294 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115,024,903 - 5,031,280 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014,978,599 - 4,984,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015,149,814 - 5,156,191 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TIMM21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115,175,702 - 5,182,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15,175,714 - 5,181,883 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha16,182,962 - 6,189,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014,986,113 - 4,992,490 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14,986,115 - 4,992,294 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115,024,903 - 5,031,280 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014,978,599 - 4,984,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015,149,814 - 5,156,191 (-)NCBIUU_Cfam_GSD_1.0
TIMM21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381874,148,523 - 74,160,531 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1874,148,523 - 74,160,531 (+)EnsemblGRCh38hg38GRCh38
GRCh371871,815,758 - 71,827,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361869,966,726 - 69,977,184 (+)NCBINCBI36Build 36hg18NCBI36
Build 341869,966,824 - 69,977,067NCBI
Celera1868,680,277 - 68,690,735 (+)NCBICelera
Cytogenetic Map18q22.3NCBI
HuRef1868,548,250 - 68,558,708 (+)NCBIHuRef
CHM1_11871,810,946 - 71,821,404 (+)NCBICHM1_1
T2T-CHM13v2.01874,369,489 - 74,381,497 (+)NCBIT2T-CHM13v2.0
Timm21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391884,964,316 - 84,970,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1884,964,316 - 84,969,649 (-)EnsemblGRCm39 Ensembl
GRCm381884,946,191 - 84,951,530 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1884,946,191 - 84,951,524 (-)EnsemblGRCm38mm10GRCm38
MGSCv371885,116,686 - 85,120,916 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361885,081,487 - 85,085,717 (-)NCBIMGSCv36mm8
Celera1886,012,402 - 86,016,632 (-)NCBICelera
Cytogenetic Map18E4NCBI
cM Map1857.53NCBI
Timm21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81880,589,775 - 80,594,237 (-)NCBIGRCr8
mRatBN7.21878,314,900 - 78,319,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1878,314,909 - 78,319,454 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1880,425,523 - 80,429,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01881,097,587 - 81,102,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01878,933,271 - 78,937,743 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01881,803,165 - 81,807,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1881,803,173 - 81,807,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01880,841,873 - 80,846,335 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41881,524,258 - 81,528,720 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11881,597,712 - 81,602,170 (-)NCBI
Celera1876,929,506 - 76,933,968 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
Timm21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540257,586,998 - 57,599,869 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540257,586,651 - 57,598,817 (+)NCBIChiLan1.0ChiLan1.0
TIMM21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21791,677,594 - 91,688,618 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11877,370,217 - 77,381,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01867,530,610 - 67,540,966 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11870,815,069 - 70,825,425 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1870,815,069 - 70,825,436 (+)Ensemblpanpan1.1panPan2
Timm21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494418,942,780 - 18,950,805 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366164,263,464 - 4,272,039 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366164,263,912 - 4,271,927 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMM21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1149,845,199 - 149,855,908 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11149,845,189 - 149,855,903 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21166,037,961 - 166,048,650 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIMM21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,735,562 - 5,745,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,734,091 - 5,745,267 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606020,137,690 - 20,147,393 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timm21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248066,510,998 - 6,520,496 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248066,509,711 - 6,520,687 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TIMM21
58 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000000046   ⟹   ENSCAFP00000000043
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl15,176,074 - 5,181,550 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086699   ⟹   ENSCAFP00000045587
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl15,175,714 - 5,181,883 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001653   ⟹   ENSCAFP00845001305
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl14,986,115 - 4,991,984 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845001658   ⟹   ENSCAFP00845001310
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl14,986,119 - 4,992,294 (-)Ensembl
RefSeq Acc Id: XM_038465189   ⟹   XP_038321117
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.115,024,903 - 5,031,280 (-)NCBI
RefSeq Acc Id: XM_038525791   ⟹   XP_038381719
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.015,149,814 - 5,156,191 (-)NCBI
RefSeq Acc Id: XM_038590092   ⟹   XP_038446020
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.014,978,599 - 4,984,976 (-)NCBI
RefSeq Acc Id: XM_038653921   ⟹   XP_038509849
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.014,986,113 - 4,992,490 (-)NCBI
RefSeq Acc Id: XM_843471   ⟹   XP_848564
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.115,175,702 - 5,182,096 (-)NCBI
Dog10K_Boxer_Tasha16,182,962 - 6,189,339 (-)NCBI
Sequence:
RefSeq Acc Id: XP_848564   ⟸   XM_843471
- UniProtKB: A0A8C0KSJ5 (UniProtKB/TrEMBL),   A0A8C0PQK4 (UniProtKB/TrEMBL),   A0A8I3MCQ0 (UniProtKB/TrEMBL),   A0A8C0LYU7 (UniProtKB/TrEMBL),   A0A8P0N390 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000043   ⟸   ENSCAFT00000000046
RefSeq Acc Id: ENSCAFP00000045587   ⟸   ENSCAFT00000086699
RefSeq Acc Id: XP_038321117   ⟸   XM_038465189
RefSeq Acc Id: XP_038446020   ⟸   XM_038590092
RefSeq Acc Id: XP_038509849   ⟸   XM_038653921
- UniProtKB: A0A8C0KSJ5 (UniProtKB/TrEMBL),   A0A8C0PQK4 (UniProtKB/TrEMBL),   A0A8I3MCQ0 (UniProtKB/TrEMBL),   A0A8C0LYU7 (UniProtKB/TrEMBL),   A0A8P0N390 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381719   ⟸   XM_038525791
- UniProtKB: A0A8C0KSJ5 (UniProtKB/TrEMBL),   A0A8C0LYU7 (UniProtKB/TrEMBL),   A0A8C0PQK4 (UniProtKB/TrEMBL),   A0A8I3MCQ0 (UniProtKB/TrEMBL),   A0A8P0N390 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845001310   ⟸   ENSCAFT00845001658
RefSeq Acc Id: ENSCAFP00845001305   ⟸   ENSCAFT00845001653


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000028 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000954 UniProtKB/TrEMBL
  ENSCAFG00040000518 UniProtKB/TrEMBL
  ENSCAFG00845000972 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000046.5 UniProtKB/TrEMBL
  ENSCAFT00030001646.1 UniProtKB/TrEMBL
  ENSCAFT00040000902.1 UniProtKB/TrEMBL
  ENSCAFT00845001653 ENTREZGENE
  ENSCAFT00845001653.1 UniProtKB/TrEMBL
  ENSCAFT00845001658.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.320 UniProtKB/TrEMBL
InterPro Tim21 UniProtKB/TrEMBL
  Tim21_IMS_sf UniProtKB/TrEMBL
KEGG Report cfa:476170 UniProtKB/TrEMBL
NCBI Gene TIMM21 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21 UniProtKB/TrEMBL
  PTHR13032 UniProtKB/TrEMBL
Pfam TIM21 UniProtKB/TrEMBL
UniProt A0A8C0KSJ5 ENTREZGENE
  A0A8C0LYU7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PQK4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MCQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MDE2_CANLF UniProtKB/TrEMBL
  A0A8P0N390 ENTREZGENE
UniProt Secondary A0A8P0N390 UniProtKB/TrEMBL
VGNC ID VGNC:49031 ENTREZGENE