PMPCB (peptidase, mitochondrial processing subunit beta) - Rat Genome Database

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Gene: PMPCB (peptidase, mitochondrial processing subunit beta) Canis lupus familiaris
Analyze
Symbol: PMPCB
Name: peptidase, mitochondrial processing subunit beta
RGD ID: 12368659
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); metallopeptidase activity (ortholog); INVOLVED IN protein processing (ortholog); protein processing involved in protein targeting to mitochondrion (ortholog); PARTICIPATES IN presequence pathway of mitochondrial protein import; ASSOCIATED WITH genetic disease (ortholog); multiple mitochondrial dysfunctions syndrome 6 (ortholog); Norman-Roberts syndrome (ortholog); FOUND IN mitochondrial processing peptidase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitochondrial-processing peptidase subunit beta; peptidase, mitochondrial processing beta subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,894,240 - 16,906,988 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,894,276 - 16,906,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1816,541,779 - 16,554,661 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01817,189,094 - 17,201,917 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1817,189,094 - 17,201,922 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11816,954,255 - 16,967,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,893,175 - 16,906,045 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01817,161,401 - 17,174,292 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PMPCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,894,240 - 16,906,988 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,894,276 - 16,906,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1816,541,779 - 16,554,661 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01817,189,094 - 17,201,917 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1817,189,094 - 17,201,922 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11816,954,255 - 16,967,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,893,175 - 16,906,045 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01817,161,401 - 17,174,292 (-)NCBIUU_Cfam_GSD_1.0
PMPCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387103,297,435 - 103,347,542 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7103,297,407 - 103,331,818 (+)EnsemblGRCh38hg38GRCh38
GRCh377102,937,882 - 102,955,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,725,109 - 102,742,369 (+)NCBINCBI36Build 36hg18NCBI36
Build 347102,531,849 - 102,546,957NCBI
Celera797,745,096 - 97,762,356 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef797,300,090 - 97,317,351 (+)NCBIHuRef
CHM1_17102,870,874 - 102,888,137 (+)NCBICHM1_1
T2T-CHM13v2.07104,611,886 - 104,661,980 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27102,298,239 - 102,315,499 (+)NCBI
Pmpcb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39521,942,158 - 21,962,150 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl521,942,139 - 21,962,150 (+)EnsemblGRCm39 Ensembl
GRCm38521,737,160 - 21,757,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,737,141 - 21,757,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv37521,242,978 - 21,262,970 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36521,248,972 - 21,268,978 (+)NCBIMGSCv36mm8
Celera518,708,080 - 18,728,070 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.97NCBI
Pmpcb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,189,807 - 14,202,584 (-)NCBIGRCr8
mRatBN7.2413,297,583 - 13,310,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl413,297,559 - 13,310,367 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx418,442,919 - 18,455,706 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,257,272 - 14,270,040 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,628,556 - 12,641,349 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,908,838 - 9,921,615 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,908,831 - 9,921,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,909,996 - 9,922,773 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,746,904 - 8,759,681 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.148,746,903 - 8,759,681 (-)NCBI
Celera48,888,496 - 8,901,273 (-)NCBICelera
Cytogenetic Map4q11NCBI
Pmpcb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,303,901 - 8,317,447 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554108,304,088 - 8,317,639 (+)NCBIChiLan1.0ChiLan1.0
PMPCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26140,156,553 - 140,193,141 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17188,426,523 - 188,458,972 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0795,288,747 - 95,320,294 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17108,033,235 - 108,048,291 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,033,235 - 108,050,302 (+)Ensemblpanpan1.1panPan2
Pmpcb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511859,074,586 - 59,086,415 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647920,198,417 - 20,210,202 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647920,198,417 - 20,210,160 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMPCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,316,190 - 103,330,290 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19103,316,161 - 103,329,653 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29113,924,688 - 113,938,159 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PMPCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,271,390 - 72,286,559 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2172,271,429 - 72,286,265 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604231,716,546 - 31,731,588 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmpcb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473926,045,982 - 26,061,465 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473926,045,745 - 26,061,509 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PMPCB
142 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000006689   ⟹   ENSCAFP00000006194
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1816,894,276 - 16,906,979 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845034368   ⟹   ENSCAFP00845026907
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1817,189,094 - 17,201,922 (-)Ensembl
RefSeq Acc Id: XM_005630976   ⟹   XP_005631033
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11816,894,240 - 16,906,988 (-)NCBI
Dog10K_Boxer_Tasha1816,541,779 - 16,554,661 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038423865   ⟹   XP_038279793
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01817,189,094 - 17,201,917 (-)NCBI
RefSeq Acc Id: XM_038500223   ⟹   XP_038356151
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11816,954,255 - 16,967,152 (-)NCBI
RefSeq Acc Id: XM_038562779   ⟹   XP_038418707
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01817,161,401 - 17,174,292 (-)NCBI
RefSeq Acc Id: XM_038626890   ⟹   XP_038482818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01816,893,175 - 16,906,045 (-)NCBI
RefSeq Acc Id: XP_005631033   ⟸   XM_005630976
- UniProtKB: A0A8C0LHX2 (UniProtKB/TrEMBL),   A0A8C0SQP4 (UniProtKB/TrEMBL),   A0A8I3NYF1 (UniProtKB/TrEMBL),   A0A8C0LFD5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000006194   ⟸   ENSCAFT00000006689
RefSeq Acc Id: XP_038356151   ⟸   XM_038500223
RefSeq Acc Id: XP_038482818   ⟸   XM_038626890
RefSeq Acc Id: XP_038279793   ⟸   XM_038423865
- UniProtKB: A0A8C0LHX2 (UniProtKB/TrEMBL),   A0A8C0SQP4 (UniProtKB/TrEMBL),   A0A8I3NYF1 (UniProtKB/TrEMBL),   A0A8C0LFD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038418707   ⟸   XM_038562779
- UniProtKB: A0A8C0LFD5 (UniProtKB/TrEMBL),   A0A8C0LHX2 (UniProtKB/TrEMBL),   A0A8C0SQP4 (UniProtKB/TrEMBL),   A0A8I3NYF1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845026907   ⟸   ENSCAFT00845034368
Protein Domains
Peptidase M16 C-terminal   Peptidase M16 N-terminal

Promoters
RGD ID:13686447
Promoter ID:EPDNEW_C4515
Type:multiple initiation site
Name:PMPCB_1
Description:peptidase, mitochondrial processing beta subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11816,906,986 - 16,907,046EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004166 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015291 UniProtKB/TrEMBL
  ENSCAFG00040015020 UniProtKB/TrEMBL
  ENSCAFG00845019441 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006689.5 UniProtKB/TrEMBL
  ENSCAFT00030028334.1 UniProtKB/TrEMBL
  ENSCAFT00040027806.1 UniProtKB/TrEMBL
  ENSCAFT00040027906.1 UniProtKB/TrEMBL
  ENSCAFT00845034368 ENTREZGENE
  ENSCAFT00845034368.1 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/TrEMBL
InterPro Metalloenz_LuxS/M16 UniProtKB/TrEMBL
  MPP/UQCRC_Complex UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/TrEMBL
  Pept_M16_Zn_BS UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
KEGG Report cfa:475897 UniProtKB/TrEMBL
NCBI Gene PMPCB ENTREZGENE
PANTHER METALLOPROTEASE UniProtKB/TrEMBL
  PTHR11851:SF103 UniProtKB/TrEMBL
Pfam Peptidase_M16 UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
PROSITE INSULINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF63411 UniProtKB/TrEMBL
UniProt A0A8C0LFD5 ENTREZGENE
  A0A8C0LHX2 ENTREZGENE
  A0A8C0SPW3_CANLF UniProtKB/TrEMBL
  A0A8C0SQP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NYF1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44737 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-11 PMPCB  peptidase, mitochondrial processing subunit beta  PMPCB  peptidase, mitochondrial processing beta subunit  Symbol and/or name change 19259463 PROVISIONAL