RGD Reference Report - Processing of mitochondrial presequences. - Rat Genome Database

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Processing of mitochondrial presequences.

Authors: Mossmann, D  Meisinger, C  Vogtle, FN 
Citation: Mossmann D, etal., Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):1098-106. doi: 10.1016/j.bbagrm.2011.11.007. Epub 2011 Dec 7.
RGD ID: 10412669
Pubmed: PMID:22172993   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbagrm.2011.11.007   (Journal Full-text)

Mitochondrial proteins are synthesized as precursor proteins on either cytosolic or mitochondrial ribosomes. The synthesized precursors from both translation origins possess targeting signals that guide the protein to its final destination in one of the four subcompartments of the organelle. The majority of nuclear-encoded mitochondrial precursors and also mitochondrial-encoded preproteins have an N-terminal presequence that serves as a targeting sequence. Specific presequence peptidases that are found in the matrix, inner membrane and intermembrane space of mitochondria proteolytically remove the signal sequence upon import or sorting. Besides the classical presequence peptidases MPP, IMP and Oct1, several novel proteases have recently been described to possess precursor processing activity, and analysis of their functional relevance revealed a tight connection between precursor processing, mitochondrial dynamics and protein quality control. This article is part of a Special Issue entitled: Mitochondrial Gene Expression.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IMMP1LHumanpresequence pathway of mitochondrial protein import  TAS  RGD 
IMMP2LHumanpresequence pathway of mitochondrial protein import  TAS  RGD 
Immp1lRatpresequence pathway of mitochondrial protein import  ISOIMMP1L (Homo sapiens) RGD 
Immp1lMousepresequence pathway of mitochondrial protein import  ISOIMMP1L (Homo sapiens) RGD 
Immp2lMousepresequence pathway of mitochondrial protein import  ISOIMMP2L (Homo sapiens) RGD 
Immp2lRatpresequence pathway of mitochondrial protein import  ISOIMMP2L (Homo sapiens) RGD 
MIPEPHumanpresequence pathway of mitochondrial protein import  TAS  RGD 
MipepRatpresequence pathway of mitochondrial protein import  ISOMIPEP (Homo sapiens) RGD 
MipepMousepresequence pathway of mitochondrial protein import  ISOMIPEP (Homo sapiens) RGD 
PMPCAHumanpresequence pathway of mitochondrial protein import  TAS  RGD 
PMPCBHumanpresequence pathway of mitochondrial protein import  TAS  RGD 
PmpcaRatpresequence pathway of mitochondrial protein import  ISOPMPCA (Homo sapiens) RGD 
PmpcaMousepresequence pathway of mitochondrial protein import  ISOPMPCA (Homo sapiens) RGD 
PmpcbRatpresequence pathway of mitochondrial protein import  ISOPMPCB (Homo sapiens) RGD 
PmpcbMousepresequence pathway of mitochondrial protein import  ISOPMPCB (Homo sapiens) RGD 
XPNPEP3Humanpresequence pathway of mitochondrial protein import  TAS  RGD 
Xpnpep3Mousepresequence pathway of mitochondrial protein import  ISOXPNPEP3 (Homo sapiens) RGD 
Xpnpep3Ratpresequence pathway of mitochondrial protein import  ISOXPNPEP3 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Immp1l  (inner mitochondrial membrane peptidase subunit 1)
Immp2l  (inner mitochondrial membrane peptidase subunit 2)
Mipep  (mitochondrial intermediate peptidase)
Pmpca  (peptidase, mitochondrial processing subunit alpha)
Pmpcb  (peptidase, mitochondrial processing subunit beta)
Xpnpep3  (X-prolyl aminopeptidase 3)

Genes (Mus musculus)
Immp1l  (IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae))
Immp2l  (IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae))
Mipep  (mitochondrial intermediate peptidase)
Pmpca  (peptidase (mitochondrial processing) alpha)
Pmpcb  (peptidase (mitochondrial processing) beta)
Xpnpep3  (X-prolyl aminopeptidase 3, mitochondrial)

Genes (Homo sapiens)
IMMP1L  (inner mitochondrial membrane peptidase subunit 1)
IMMP2L  (inner mitochondrial membrane peptidase subunit 2)
MIPEP  (mitochondrial intermediate peptidase)
PMPCA  (peptidase, mitochondrial processing subunit alpha)
PMPCB  (peptidase, mitochondrial processing subunit beta)
XPNPEP3  (X-prolyl aminopeptidase 3)


Additional Information