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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:parathyroid hormone signaling pathway
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Accession:PW:0001135 term browser browse the term
Definition:Parathyroid hormone (PTH) signaling is important for calcium and phosphate homeostasis in bone and kidney. It acts to increase the concentration of calcium in the blood, has both anabolic and catabolic effects in the bone and regulates calcium and phosphate reabsorption in the kidney. It also plays important roles in vitamin D metabolism.
Synonyms:related_synonym: PTH signaling pathway
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parathyroid hormone signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB1 arrestin beta 1 TAS RGD PMID:20703892 RGD:7207469 NCBI chr11:75,260,122...75,351,661
Ensembl chr11:75,260,122...75,351,705 		JBrowse link
G ARRB2 arrestin beta 2 TAS RGD PMID:20703892 RGD:7207469 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G EZR ezrin TAS RGD PMID:21777186 RGD:7207465 NCBI chr 6:158,765,748...158,819,368
Ensembl chr 6:158,765,741...158,819,368 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 TAS RGD PMID:19395963 RGD:7207470 NCBI chr11:67,266,473...67,286,556
Ensembl chr11:67,266,473...67,286,556 		JBrowse link
G NHERF1 NHERF family PDZ scaffold protein 1 TAS RGD PMID:21777186 RGD:7207465 NCBI chr17:74,748,628...74,769,353
Ensembl chr17:74,748,628...74,769,353 		JBrowse link
G NHERF2 NHERF family PDZ scaffold protein 2 TAS RGD PMID:21777186 RGD:7207465 NCBI chr16:2,026,902...2,039,026
Ensembl chr16:2,025,356...2,039,026 		JBrowse link
G PTH parathyroid hormone ISO
TAS		 RGD PMID:9054374 PMID:19395963 PMID:21777186 RGD:7207455, RGD:7207470, RGD:7207465 NCBI chr11:13,492,054...13,496,181
Ensembl chr11:13,492,054...13,496,181 		JBrowse link
G PTH1R parathyroid hormone 1 receptor ISO
TAS		 RGD PMID:9054374 PMID:19395963 PMID:20703892 PMID:21777186 RGD:7207455, RGD:7207470, RGD:7207469, RGD:7207465 NCBI chr 3:46,877,721...46,903,799
Ensembl chr 3:46,877,721...46,903,799 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    signaling pathway 2493
      hormone signaling pathway 563
        peptide and protein hormone signaling pathway 446
          parathyroid hormone family signaling pathway 8
            parathyroid hormone signaling pathway 8
Path 2
Term Annotations click to browse term
  pathway 5957
    regulatory pathway 3600
      homeostasis pathway 1667
        inorganic chemical homeostasis pathway 293
          metal homeostasis pathway 201
            calcium homeostasis pathway 139
              parathyroid hormone signaling pathway 8
paths to the root