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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:angiotensin II signaling pathway via AT1 receptor
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Accession:PW:0000527 term browser browse the term
Definition:Angiotensin II signaling through the angiotensin type 1 receptor (AT1) activates downstream signaling pathways and elicits a broad range of physiological responses. It is involved in the regulation of blood pressure and volume, water and electrolyte balance and exerts a potent vasoconstrictive effect.
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angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:16141358 RGD:1581847 NCBI chr25:67,964,840...67,977,006
Ensembl chr25:67,962,401...67,973,324 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:9287353 PMID:10977869 PMID:12446719 PMID:14559250 RGD:1581825 RGD:2316188 RGD:5133683 RGD:629553 NCBI chr15:41,957,826...42,002,776 JBrowse link
G AGTRAP angiotensin II receptor associated protein ISO RGD PMID:17875818 RGD:2314353 NCBI chr20:120,041,804...120,056,597
Ensembl chr20:120,041,479...120,056,557 		JBrowse link
G ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 ISO RGD PMID:14559250 RGD:2316188 NCBI chr 1:63,923,241...63,991,221
Ensembl chr 1:63,920,076...63,960,771 		JBrowse link
G ARRB1 arrestin beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:66,489,358...66,580,167
Ensembl chr 1:66,490,102...66,580,154 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr16:4,191,040...4,202,382
Ensembl chr16:4,191,172...4,202,385 		JBrowse link
G GNA11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chr 6:2,858,880...2,887,694
Ensembl chr 6:2,858,937...2,887,704 		JBrowse link
G GNAQ G protein subunit alpha q ISO RGD PMID:16141358 RGD:1581847 NCBI chr12:88,666,375...88,988,989
Ensembl chr12:88,670,424...88,871,154 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:6,975,202...6,995,369
Ensembl chr 1:6,975,002...6,995,259 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr19:8,438,543...8,601,652
Ensembl chr19:8,438,380...8,600,359 		JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 9:111,996,780...112,249,247
Ensembl chr 9:111,996,599...112,244,570 		JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr23:79,437,056...79,454,213
Ensembl chr23:79,437,078...79,453,113 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:9287353 PMID:9314843 RGD:5133683 RGD:6478796 NCBI chr12:74,421,243...74,566,766
Ensembl chr12:74,421,016...74,566,710 		JBrowse link
G RGS2 regulator of G protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr25:36,620,047...36,623,367
Ensembl chr25:36,619,140...36,623,308 		JBrowse link
G TYK2 tyrosine kinase 2 ISO RGD PMID:9314843 RGD:6478796 NCBI chr 6:9,399,945...9,420,054
Ensembl chr 6:9,399,775...9,417,630 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    signaling pathway 1919
      hormone signaling pathway 377
        peptide and protein hormone signaling pathway 270
          angiotensin signaling pathway 39
            angiotensin II signaling pathway 32
              angiotensin II signaling pathway via AT1 receptor 15
Path 2
Term Annotations click to browse term
  pathway 4028
    regulatory pathway 2488
      homeostasis pathway 1295
        cardiovascular system homeostasis pathway 263
          renin-angiotensin cascade pathway 43
            angiotensin signaling pathway 39
              angiotensin II signaling pathway 32
                angiotensin II signaling pathway via AT1 receptor 15
paths to the root