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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:angiotensin II signaling pathway
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Accession:PW:0000244 term browser browse the term
Definition:Angiotensin II signaling pathways play a critical role in the control of cardiovascular and renal homeostasis. Angiotensin II pathway can also contribute to cardiovascular diseases such as hypertension, atherosclerosis and heart failure.
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angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO RGD PMID:15638741 RGD:1581742 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS RGD PMID:15590154 RGD:1579760 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS RGD PMID:14657020 RGD:1566502 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP RGD PMID:14684844 RGD:1582323 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cma1 chymase 1 IMP RGD PMID:15869764 RGD:1581745 NCBI chr15:33,387,351...33,390,133
Ensembl chr15:33,387,351...33,390,133 		JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:16269269 RGD:1600094 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 IEP RGD PMID:12661921 RGD:1580992 NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:164,612,463...164,634,598 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IDA RGD PMID:14585963 RGD:1581775 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pla2g6 phospholipase A2 group VI IMP RGD PMID:17613534 RGD:12910844 NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609 		JBrowse link
G Prkcz protein kinase C, zeta IMP RGD PMID:16113073 RGD:1642674 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674 		JBrowse link
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
IMP
IDA 		RGD PMID:10977869 PMID:12446719 PMID:9287353 PMID:14559250 RGD:1581825, RGD:629553, RGD:5133683, RGD:2316188 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:10977869 RGD:1581825 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:104,773,930...104,849,310 		JBrowse link
G Agtrap angiotensin II receptor-associated protein IMP RGD PMID:17875818 RGD:2314353 NCBI chr 5:163,790,565...163,802,174
Ensembl chr 5:163,791,887...163,802,174 		JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 IDA RGD PMID:14559250 RGD:2316188 NCBI chr 1:165,160,701...165,226,219
Ensembl chr 1:165,160,678...165,226,218 		JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chr 7:8,814,285...8,828,628
Ensembl chr 7:8,814,327...8,830,558 		JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:16141358 RGD:1581847 NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr12:49,285,228...49,395,803
Ensembl chr12:49,285,263...49,395,802 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,182,160...9,197,954 		JBrowse link
G Jak2 Janus kinase 2 IDA
IMP 		RGD PMID:9287353 PMID:9314843 RGD:5133683, RGD:6478796 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697 		JBrowse link
G Tyk2 tyrosine kinase 2 IMP RGD PMID:9314843 RGD:6478796 NCBI chr 8:27,918,054...27,943,319
Ensembl chr 8:27,916,496...27,943,278 		JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP
TAS
ISO 		RGD PMID:16286564 PMID:16286568 PMID:22949090 RGD:1582434, RGD:1582435, RGD:7401256 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
ISO 		RGD PMID:10977869 PMID:22949090 RGD:1581825, RGD:7401256 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 5:151,731,222...151,742,049
Ensembl chr 5:151,731,224...151,742,203 		JBrowse link
G Dusp1 dual specificity phosphatase 1 TAS RGD PMID:18804122 RGD:5133675 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 2:198,430,920...198,468,874 JBrowse link
G Mtus1 microtubule associated scaffold protein 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr16:57,905,991...58,051,466
Ensembl chr16:57,906,128...58,051,474 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO RGD PMID:18804122 RGD:5133675 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 ISO RGD PMID:20889352 RGD:5133679 NCBI chr  X:139,468,045...139,524,111
Ensembl chr  X:139,458,127...139,524,109 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:57,891,081...58,073,507 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          angiotensin signaling pathway 41
            angiotensin II signaling pathway 34
              angiotensin II signaling pathway via AT1 receptor 16
              angiotensin II signaling pathway via AT2 receptor 12
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3866
      homeostasis pathway 1773
        cardiovascular system homeostasis pathway 423
          renin-angiotensin cascade pathway 52
            angiotensin signaling pathway 41
              angiotensin II signaling pathway 34
                angiotensin II signaling pathway via AT1 receptor 16
                angiotensin II signaling pathway via AT2 receptor 12
paths to the root