PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: renin-angiotensin cascade pathway
Accession: PW:0000492
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Definition: The renin-angiotensin cascade (RAS) generates a number of bioactive peptides with diverse physiological and pathophysiological functions. RAS exerts vasoconstriction, vasodilation or vascular remodeling, cell proliferation or anti-proliferation effects, depending on which angiotensin peptide generates the signaling. Some of these features are also shared by the kallikrein-kinin system (KKS); the two systems can interact and cross-talk.
Synonyms: related_synonym: KEGG:04614; RAS system signaling pathway
View Interactive Diagram
G
Ace
angiotensin I converting enzyme
ISO IEA IMP
KEGG RGD
PMID:15638741 PMID:10642323
rno:04614, RGD:1581742 , RGD:1581953
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2
angiotensin converting enzyme 2
ISO IEA
KEGG RGD
PMID:15638741 PMID:16520407
rno:04614, RGD:1581742 , RGD:1581931
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Agt
angiotensinogen
IDA IEA IMP ISO
KEGG RGD
PMID:12242043 PMID:11282364 PMID:15638741
rno:04614, RGD:1581651 , RGD:1582105 , RGD:1581742
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Agtr1a
angiotensin II receptor, type 1a
TAS IEA
KEGG RGD
PMID:16141358
rno:04614, RGD:1581847
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Agtr1b
angiotensin II receptor, type 1b
TAS IEA
KEGG RGD
PMID:16141358
rno:04614, RGD:1581847
NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
G
Agtr2
angiotensin II receptor, type 2
TAS IEA
KEGG RGD
PMID:15158138
rno:04614, RGD:1581855
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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Anpep
alanyl aminopeptidase, membrane
IDA IEA
KEGG RGD
PMID:16537183
rno:04614, RGD:1581649
NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
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Atp6ap2
ATPase H+ transporting accessory protein 2
ISO
RGD
PMID:18376005
RGD:5132617
NCBI chr X:10,183,983...10,210,948
Ensembl chr X:10,183,068...10,210,918
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Cma1
chymase 1
TAS IEA
KEGG RGD
PMID:15638741
rno:04614, RGD:1581742
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
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Cpa3
carboxypeptidase A3
IEA
KEGG
rno:04614
NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203
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Ctsa
cathepsin A
IEA
KEGG
rno:04614
NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215
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Ctsg
cathepsin G
IEA
KEGG
rno:04614
NCBI chr15:29,930,988...29,937,353
Ensembl chr15:29,931,003...29,937,353
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Enpep
glutamyl aminopeptidase
IDA IEA ISO
KEGG RGD
PMID:16537183 PMID:15638741
rno:04614, RGD:1581649 , RGD:1581742
NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
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Igf2r
insulin-like growth factor 2 receptor
IDA TAS
RGD
PMID:11247783 PMID:16672920
RGD:1581738 , RGD:1581739
NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
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Lnpep
leucyl and cystinyl aminopeptidase
TAS IEA IMP
KEGG RGD
PMID:15687842 PMID:11282364
rno:04614, RGD:1581849 , RGD:1582105
NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544
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Mas1
MAS1 proto-oncogene, G protein-coupled receptor
TAS IEA ISO
KEGG RGD
PMID:15687842 PMID:16520407
rno:04614, RGD:1581849 , RGD:1581931
NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
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Mcpt8l2
mast cell protease 8-like 2
IEA
KEGG
rno:04614
G
Mcpt8l3
mast cell protease 8-like 3
IEA
KEGG
rno:04614
G
Mme
membrane metallo-endopeptidase
ISO IEA IMP
KEGG RGD
PMID:15638741 PMID:10642323 PMID:16520407
rno:04614, RGD:1581742 , RGD:1581953 , RGD:1581931
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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Nln
neurolysin
IEA
KEGG
rno:04614
NCBI chr 2:35,133,634...35,232,927
Ensembl chr 2:35,134,145...35,232,914
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Ren
renin
IDA IEA ISO TAS
KEGG RGD
PMID:12242043 PMID:15638741 PMID:16672920 PMID:11247783
rno:04614, RGD:1581651 , RGD:1581742 , RGD:1581739 , RGD:1581738
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Renbp
renin binding protein
IDA
RGD
PMID:11726282
RGD:5132613
NCBI chr X:151,661,463...151,670,538
Ensembl chr X:151,661,458...151,670,516
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Rnpep
arginyl aminopeptidase
IDA
RGD
PMID:16537183
RGD:1581649
NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
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Thop1
thimet oligopeptidase 1
IEA
KEGG
rno:04614
NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275
G
Ace
angiotensin I converting enzyme
IMP ISO
RGD
PMID:10642323 PMID:15283675
RGD:1581953 , RGD:1598433
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
G
Ace2
angiotensin converting enzyme 2
ISO
RGD
PMID:15638741
RGD:1581742
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
G
Agt
angiotensinogen
IMP
RGD
PMID:15951342
RGD:1581938
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Mas1
MAS1 proto-oncogene, G protein-coupled receptor
IMP ISO
RGD
PMID:15951342 PMID:16520407
RGD:1581938 , RGD:1581931
NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
G
Mme
membrane metallo-endopeptidase
ISO IMP
RGD
PMID:15638741 PMID:16520407 PMID:10642323
RGD:1581742 , RGD:1581931 , RGD:1581953
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
G
Ace
angiotensin I converting enzyme
ISO
RGD
PMID:15638741
RGD:1581742
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
G
Agt
angiotensinogen
TAS
RGD
PMID:16141358
RGD:1581847
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Agtr1a
angiotensin II receptor, type 1a
TAS
RGD
PMID:15590154
RGD:1579760
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
G
Agtr2
angiotensin II receptor, type 2
TAS
RGD
PMID:14657020
RGD:1566502
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
G
Ccl2
C-C motif chemokine ligand 2
IEP
RGD
PMID:14684844
RGD:1582323
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Cma1
chymase 1
IMP
RGD
PMID:15869764
RGD:1581745
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
G
Jak2
Janus kinase 2
IMP
RGD
PMID:16269269
RGD:1600094
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
G
Olr1
oxidized low density lipoprotein receptor 1
IEP
RGD
PMID:12661921
RGD:1580992
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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Pdpk1
3-phosphoinositide dependent protein kinase-1
IDA
RGD
PMID:14585963
RGD:1581775
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
G
Pla2g6
phospholipase A2 group VI
IMP
RGD
PMID:17613534
RGD:12910844
NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
G
Prkcz
protein kinase C, zeta
IMP
RGD
PMID:16113073
RGD:1642674
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
G
Agt
angiotensinogen
TAS
RGD
PMID:16141358
RGD:1581847
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Agtr1a
angiotensin II receptor, type 1a
TAS IMP IDA
RGD
PMID:10977869 PMID:12446719 PMID:9287353 PMID:14559250
RGD:1581825 , RGD:629553 , RGD:5133683 , RGD:2316188
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
G
Agtr1b
angiotensin II receptor, type 1b
TAS
RGD
PMID:10977869
RGD:1581825
NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
G
Agtrap
angiotensin II receptor-associated protein
IMP
RGD
PMID:17875818
RGD:2314353
NCBI chr 5:158,507,427...158,519,036
Ensembl chr 5:158,508,749...158,519,036
G
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDA
RGD
PMID:14559250
RGD:2316188
NCBI chr 1:155,748,622...155,814,186
Ensembl chr 1:155,748,652...155,814,184
G
Arrb1
arrestin, beta 1
ISO
RGD
PMID:16304060
RGD:5133417
NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
G
Arrb2
arrestin, beta 2
ISO
RGD
PMID:16304060
RGD:5133417
NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
G
Gna11
G protein subunit alpha 11
ISO
RGD
PMID:16141358
RGD:1581847
NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812
G
Gnaq
G protein subunit alpha q
ISO
RGD
PMID:16141358
RGD:1581847
NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
G
Grk2
G protein-coupled receptor kinase 2
ISO
RGD
PMID:16304060
RGD:5133417
NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
G
Grk3
G protein-coupled receptor kinase 3
ISO
RGD
PMID:16304060
RGD:5133417
NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
G
Grk5
G protein-coupled receptor kinase 5
ISO
RGD
PMID:16304060
RGD:5133417
NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
G
Grk6
G protein-coupled receptor kinase 6
ISO
RGD
PMID:16304060
RGD:5133417
NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644
G
Jak2
Janus kinase 2
IDA IMP
RGD
PMID:9287353 PMID:9314843
RGD:5133683 , RGD:6478796
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
G
Rgs2
regulator of G-protein signaling 2
ISO
RGD
PMID:12588881
RGD:5133418
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
G
Tyk2
tyrosine kinase 2
IMP
RGD
PMID:9314843
RGD:6478796
NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044
G
Agt
angiotensinogen
IMP ISO TAS
RGD
PMID:16286564 PMID:22949090 PMID:16286568
RGD:1582434 , RGD:7401256 , RGD:1582435
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Agtr2
angiotensin II receptor, type 2
TAS ISO
RGD
PMID:10977869 PMID:22949090
RGD:1581825 , RGD:7401256
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
G
Cnksr1
connector enhancer of kinase suppressor of Ras 1
ISO
RGD
PMID:20889352
RGD:5133679
NCBI chr 5:146,447,495...146,458,332
Ensembl chr 5:146,447,497...146,458,212
G
Dusp1
dual specificity phosphatase 1
TAS
RGD
PMID:18804122
RGD:5133675
NCBI chr10:16,680,478...16,683,275
G
Erbb3
erb-b2 receptor tyrosine kinase 3
ISO
RGD
PMID:20889352
RGD:5133679
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
G
Gnai2
G protein subunit alpha i2
ISO
RGD
PMID:22949090
RGD:7401256
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
G
Gnai3
G protein subunit alpha i3
ISO
RGD
PMID:22949090
RGD:7401256
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
G
Mtus1
microtubule associated scaffold protein 1
ISO
RGD
PMID:20889352
RGD:5133679
NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793
G
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
ISO
RGD
PMID:18804122
RGD:5133675
NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
G
Slc9a6
solute carrier family 9 member A6
ISO
RGD
PMID:20889352
RGD:5133679
NCBI chr X:134,430,677...134,486,747
Ensembl chr X:134,420,756...134,485,375
G
Timp3
TIMP metallopeptidase inhibitor 3
ISO
RGD
PMID:20889352
RGD:5133679
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
G
Zbtb16
zinc finger and BTB domain containing 16
ISO
RGD
PMID:20889352
RGD:5133679
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
G
Agt
angiotensinogen
TAS
RGD
PMID:11295571
RGD:1582124
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Agtr1a
angiotensin II receptor, type 1a
TAS
RGD
PMID:11295571
RGD:1582124
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
G
Agtr1b
angiotensin II receptor, type 1b
TAS
RGD
PMID:11295571
RGD:1582124
NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
G
Agtr2
angiotensin II receptor, type 2
TAS
RGD
PMID:11295571
RGD:1582124
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
G
Enpep
glutamyl aminopeptidase
IDA
RGD
PMID:16537183
RGD:1581649
NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
G
Agt
angiotensinogen
IMP
RGD
PMID:11100981
RGD:1582152
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Agt
angiotensinogen
IMP
RGD
PMID:16380540
RGD:1582118
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Agtr2
angiotensin II receptor, type 2
IMP
RGD
PMID:16380540
RGD:1582118
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
G
Agt
angiotensinogen
IMP
RGD
PMID:11282364
RGD:1582105
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Anpep
alanyl aminopeptidase, membrane
IDA
RGD
PMID:16537183
RGD:1581649
NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
G
Lnpep
leucyl and cystinyl aminopeptidase
TAS IMP
RGD
PMID:12591177 PMID:11282364
RGD:1581864 , RGD:1582105
NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544
G
Rnpep
arginyl aminopeptidase
IDA
RGD
PMID:16537183
RGD:1581649
NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
G
Agt
angiotensinogen
ISS
RGD
PMID:12676165
RGD:1566511
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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