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ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
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Accession:GO:0140627 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.
Synonyms:exact_synonym: DesCEND


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ubiquitin-dependent protein catabolic process via the C-end degron rule pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CUL2 cullin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:35,127,771...35,210,108
Ensembl chr10:35,704,964...35,787,014 		JBrowse link
G CUL4A cullin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:94,350,484...94,409,183
Ensembl chr13:113,428,271...113,472,701 		JBrowse link
G DCAF12 DDB1 and CUL4 associated factor 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:33,923,900...33,964,443
Ensembl chr 9:34,733,845...34,775,624 		JBrowse link
G FEM1A fem-1 homolog A involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,811,911...3,821,373 JBrowse link
G FEM1B fem-1 homolog B involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:47,236,920...47,254,878
Ensembl chr15:66,005,614...66,024,007 		JBrowse link
G FEM1C fem-1 homolog C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:110,878,460...110,902,650
Ensembl chr 5:116,675,163...116,699,085 		JBrowse link
G KLHDC1 kelch domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:30,272,009...30,334,693
Ensembl chr14:48,580,779...48,642,724 		JBrowse link
G KLHDC10 kelch domain containing 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:122,036,564...122,101,840
Ensembl chr 7:134,555,062...134,620,225 		JBrowse link
G KLHDC2 kelch domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:30,356,506...30,372,018
Ensembl chr14:48,668,025...48,679,105 		JBrowse link
G KLHDC3 kelch domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,606,462...42,613,565
Ensembl chr 6:43,900,902...43,908,556 		JBrowse link
G RBX1 ring-box 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:21,845,351...21,866,627
Ensembl chr22:39,941,405...39,962,175 		JBrowse link
G TRPC4AP transient receptor potential cation channel subfamily C member 4 associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:31,330,860...31,420,662
Ensembl chr20:32,455,536...32,545,780 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16442
    metabolic process 10307
      primary metabolic process 8924
        protein metabolic process 3923
          protein catabolic process 991
            proteasomal protein catabolic process 520
              proteasome-mediated ubiquitin-dependent protein catabolic process 384
                ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 12
Path 2
Term Annotations click to browse term
  biological_process 16442
    metabolic process 10307
      organic substance metabolic process 9873
        organic substance catabolic process 2050
          organonitrogen compound catabolic process 1381
            protein catabolic process 991
              proteolysis involved in protein catabolic process 744
                modification-dependent protein catabolic process 583
                  ubiquitin-dependent protein catabolic process 570
                    proteasome-mediated ubiquitin-dependent protein catabolic process 384
                      ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 12
paths to the root