KLHDC1 (kelch domain containing 1) - Rat Genome Database

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Gene: KLHDC1 (kelch domain containing 1) Pan paniscus
Analyze
Symbol: KLHDC1
Name: kelch domain containing 1
RGD ID: 11903381
Description: ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (inferred); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); genetic disease (ortholog); FOUND IN Cul5-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21550,818,340 - 50,884,484 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11450,034,884 - 50,098,487 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01430,272,009 - 30,334,693 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11448,580,779 - 48,642,736 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1448,580,779 - 48,642,724 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
KLHDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21550,818,340 - 50,884,484 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11450,034,884 - 50,098,487 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01430,272,009 - 30,334,693 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11448,580,779 - 48,642,736 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1448,580,779 - 48,642,724 (+)Ensemblpanpan1.1panPan2
KLHDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381449,693,120 - 49,753,150 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1449,693,105 - 49,753,150 (+)EnsemblGRCh38hg38GRCh38
GRCh371450,159,838 - 50,219,868 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,229,635 - 49,289,618 (+)NCBINCBI36Build 36hg18NCBI36
Build 341449,229,634 - 49,289,617NCBI
Celera1430,019,483 - 30,079,883 (+)NCBICelera
Cytogenetic Map14q21.3NCBI
HuRef1430,277,314 - 30,337,783 (+)NCBIHuRef
CHM1_11450,098,575 - 50,158,438 (+)NCBICHM1_1
T2T-CHM13v2.01443,891,165 - 43,951,525 (+)NCBIT2T-CHM13v2.0
Klhdc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,274,529 - 69,331,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,287,950 - 69,331,406 (+)EnsemblGRCm39 Ensembl
GRCm381269,227,729 - 69,284,646 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,241,176 - 69,284,632 (+)EnsemblGRCm38mm10GRCm38
MGSCv371270,342,819 - 70,384,948 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361270,160,437 - 70,202,566 (+)NCBIMGSCv36mm8
Celera1270,335,535 - 70,378,464 (+)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.74NCBI
Klhdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,406,226 - 93,501,475 (+)NCBIGRCr8
mRatBN7.2687,670,182 - 87,765,431 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,712,772 - 87,765,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx688,112,561 - 88,142,531 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,411,996 - 88,441,964 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0687,851,749 - 87,881,720 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0691,532,380 - 91,584,112 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,532,467 - 91,584,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06100,991,287 - 101,042,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,193,505 - 91,223,627 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1691,183,900 - 91,251,118 (+)NCBI
Celera686,211,864 - 86,241,880 (+)NCBICelera
Cytogenetic Map6q24NCBI
Klhdc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,912,303 - 12,970,474 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,914,446 - 12,970,266 (-)NCBIChiLan1.0ChiLan1.0
KLHDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,305,675 - 26,347,638 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,305,531 - 26,347,407 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha826,059,799 - 26,102,884 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0826,483,664 - 26,526,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl826,483,912 - 26,526,100 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1826,139,282 - 26,182,087 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0826,212,874 - 26,255,489 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0826,530,034 - 26,572,487 (+)NCBIUU_Cfam_GSD_1.0
Klhdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864058,347,379 - 58,395,042 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936583294,799 - 341,396 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936583294,200 - 342,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHDC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,540,547 - 179,605,628 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11179,540,222 - 179,605,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KLHDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12426,742,309 - 26,805,928 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605315,057,281 - 15,126,209 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhdc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473118,977,656 - 19,024,212 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473118,977,647 - 19,027,799 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000051642   ⟹   ENSPPAP00000028794
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1448,580,779 - 48,642,724 (+)Ensembl
RefSeq Acc Id: XM_003831743   ⟹   XP_003831791
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21550,818,340 - 50,884,483 (+)NCBI
NHGRI_mPanPan11450,034,884 - 50,098,487 (+)NCBI
Mhudiblu_PPA_v01430,272,009 - 30,334,693 (+)NCBI
PanPan1.11448,580,779 - 48,642,736 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063596195   ⟹   XP_063452265
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21550,818,379 - 50,884,484 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003831791 (Get FASTA)   NCBI Sequence Viewer  
  XP_063452265 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000028794
  ENSPPAP00000028794.1
Reference Protein Sequences
RefSeq Acc Id: XP_003831791   ⟸   XM_003831743
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BGP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000028794   ⟸   ENSPPAT00000051642
RefSeq Acc Id: XP_063452265   ⟸   XM_063596195
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037428 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051642.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/TrEMBL
InterPro Gal_Oxase/kelch_b-propeller UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
KEGG Report pps:100984316 UniProtKB/TrEMBL
NCBI Gene KLHDC1 ENTREZGENE
PANTHER KELCH DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KELCH DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam Kelch_4 UniProtKB/TrEMBL
  Kelch_5 UniProtKB/TrEMBL
Superfamily-SCOP SSF50965 UniProtKB/TrEMBL
UniProt A0A2R9BGP4 ENTREZGENE, UniProtKB/TrEMBL