Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:shelterin complex
go back to main search page
Accession:GO:0070187 term browser browse the term
Definition:A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.
Synonyms:exact_synonym: Pot1 complex;   Pot1-Tpz1 complex;   telosome


show annotations for term's descendants           Sort by:
shelterin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd adrenocortical dysplasia part_of
located_in		 IBA
ISO		 (PMID:15383534) GO_Central
MGI
ComplexPortal		 PMID:15383534 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 8:106,424,789...106,427,748
Ensembl chr 8:106,422,492...106,427,734 		JBrowse link
G Pot1a protection of telomeres 1A part_of
located_in		 ISO (PMID:15383534) MGI
ComplexPortal		 PMID:15383534 GO_REF:0000119 MGI:4834177 NCBI chr 6:25,743,939...25,809,280
Ensembl chr 6:25,743,736...25,809,245 		JBrowse link
G Pot1b protection of telomeres 1B part_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:55,958,190...56,019,647
Ensembl chr17:55,958,951...56,019,628 		JBrowse link
G Terb1 telomere repeat binding bouquet formation protein 1 part_of IDA (MGI:5704279|PMID:26548954) UniProt PMID:26548954 MGI:5704279 NCBI chr 8:105,173,350...105,236,692
Ensembl chr 8:105,173,351...105,236,542 		JBrowse link
G Terf1 telomeric repeat binding factor 1 part_of
located_in		 ISO (PMID:15383534) MGI
ComplexPortal		 PMID:15383534 GO_REF:0000119 MGI:4834177 NCBI chr 1:15,875,634...15,914,283
Ensembl chr 1:15,875,870...15,914,276 		JBrowse link
G Terf2 telomeric repeat binding factor 2 part_of
located_in		 IBA
ISO		 (PMID:15383534) GO_Central
MGI
ComplexPortal		 PMID:15383534 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 8:107,796,032...107,823,180
Ensembl chr 8:107,796,032...107,823,179 		JBrowse link
G Terf2ip telomeric repeat binding factor 2, interacting protein part_of IBA
ISO		 GO_Central
MGI		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 8:112,737,991...112,747,160
Ensembl chr 8:112,738,030...112,747,160 		JBrowse link
G Tinf2 Terf1 (TRF1)-interacting nuclear factor 2 part_of
located_in		 IBA
ISO		 (PMID:15383534) GO_Central
MGI
ComplexPortal		 PMID:15383534 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr14:55,912,120...55,919,265
Ensembl chr14:55,912,146...55,919,277 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 28586
    protein-containing complex 6185
      nuclear protein-containing complex 1285
        nuclear telomere cap complex 11
          shelterin complex 8
Path 2
Term Annotations click to browse term
  cellular_component 28586
    cellular anatomical entity 19619
      organelle 13555
        non-membrane-bounded organelle 4912
          intracellular non-membrane-bounded organelle 4910
            chromosome 1486
              chromosomal region 389
                chromosome, telomeric region 134
                  chromosome, telomeric repeat region 12
                    telomere cap complex 11
                      nuclear telomere cap complex 11
                        shelterin complex 8
paths to the root