Pot1b (protection of telomeres 1B) - Rat Genome Database

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Gene: Pot1b (protection of telomeres 1B) Mus musculus
Analyze
No known orthologs.
Symbol: Pot1b
Name: protection of telomeres 1B
RGD ID: 1623940
MGI Page MGI
Description: Enables single-stranded telomeric DNA binding activity and small GTPase binding activity. Acts upstream of or within several processes, including cellular senescence; negative regulation of DNA recombination at telomere; and protection from non-homologous end joining at telomere. Located in chromosome, telomeric region. Part of nuclear telomere cap complex. Is expressed in several structures, including brain; genitourinary system; liver; musculature; and spleen. Human ortholog(s) of this gene implicated in colorectal cancer; familial melanoma; hepatocellular carcinoma; lung cancer; and ovarian cancer. Orthologous to human POT1 (protection of telomeres 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2810458H16Rik; Pot1-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391755,958,190 - 56,019,647 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1755,958,951 - 56,019,628 (-)EnsemblGRCm39 Ensembl
GRCm381755,651,190 - 55,712,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1755,651,951 - 55,712,628 (-)EnsemblGRCm38mm10GRCm38
MGSCv371755,791,323 - 55,851,926 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,245,184 - 55,305,719 (-)NCBIMGSCv36mm8
Celera1759,076,202 - 59,131,232 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1728.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16839876   PMID:16839877   PMID:17053789   PMID:17632522  
PMID:17948054   PMID:18550783   PMID:18593874   PMID:18625717   PMID:18936156   PMID:18955498   PMID:19482563   PMID:19995905   PMID:21677750   PMID:21873635   PMID:21948176   PMID:22748632  
PMID:23685356   PMID:23954637   PMID:24091330   PMID:24120135   PMID:24469404   PMID:25056954   PMID:27113195   PMID:28115467   PMID:28437249   PMID:30022158   PMID:30082315   PMID:31043491  
PMID:33239785   PMID:33711210   PMID:34535663   PMID:35727838   PMID:37560909  


Genomics

Variants

.
Variants in Pot1b
1686 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:434
Count of miRNA genes:325
Interacting mature miRNAs:345
Transcripts:ENSMUST00000086876
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174371089167806995Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
14700692Cihvtq1_mcoxsackieviral infection heart viral titre QTL 1 (mouse)175000702870006995Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined175020395784204103Mouse
4142243Lfnq5_mlung function QTL 5 (mouse)Not determined5173897957534623Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse

Markers in Region
Pot1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17CUniSTS
cM Map17 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001374805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_028370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_151542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006524978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006524979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006524980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003952192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003952193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004939585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004939586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_876552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC154443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC182748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB642981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY030313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01174338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000086876   ⟹   ENSMUSP00000084089
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1755,958,951 - 56,019,578 (-)Ensembl
GRCm38.p6 Ensembl1755,651,951 - 55,712,578 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233301
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1756,004,094 - 56,019,628 (-)Ensembl
GRCm38.p6 Ensembl1755,697,094 - 55,712,628 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233557   ⟹   ENSMUSP00000156507
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1756,002,173 - 56,019,607 (-)Ensembl
GRCm38.p6 Ensembl1755,695,173 - 55,712,607 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233802   ⟹   ENSMUSP00000156762
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1755,958,951 - 56,019,578 (-)Ensembl
GRCm38.p6 Ensembl1755,651,951 - 55,712,578 (-)Ensembl
RefSeq Acc Id: ENSMUST00000233972   ⟹   ENSMUSP00000156746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1755,961,583 - 56,019,624 (-)Ensembl
GRCm38.p6 Ensembl1755,654,583 - 55,712,624 (-)Ensembl
RefSeq Acc Id: NM_001374805   ⟹   NP_001361734
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,624 (-)NCBI
GRCm381755,651,190 - 55,712,624 (-)NCBI
Sequence:
RefSeq Acc Id: NM_028370   ⟹   NP_082646
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,191 - 56,019,636 (-)NCBI
GRCm381755,651,191 - 55,712,636 (-)NCBI
MGSCv371755,791,323 - 55,851,926 (-)RGD
Celera1759,076,202 - 59,131,232 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_151542
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,191 - 56,019,636 (-)NCBI
GRCm381755,651,191 - 55,712,636 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006524978   ⟹   XP_006525041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
GRCm381755,652,952 - 55,712,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006524979   ⟹   XP_006525042
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
GRCm381755,652,952 - 55,712,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006524980   ⟹   XP_006525043
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,971,914 - 56,019,647 (-)NCBI
GRCm381755,664,914 - 55,712,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246645   ⟹   XP_011244947
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
GRCm381755,651,190 - 55,712,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246646   ⟹   XP_011244948
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
GRCm381755,652,521 - 55,712,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030250064   ⟹   XP_030105924
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
GRCm381755,652,952 - 55,712,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160794   ⟹   XP_036016687
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160795   ⟹   XP_036016688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003952192
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
GRCm381755,662,462 - 55,712,647 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003952193
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,959,952 - 56,019,647 (-)NCBI
GRCm381755,652,952 - 55,712,647 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004939585
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004939586
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,958,190 - 56,019,647 (-)NCBI
Sequence:
RefSeq Acc Id: XR_876552
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391755,976,740 - 56,019,647 (-)NCBI
GRCm381755,669,740 - 55,712,647 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_082646   ⟸   NM_028370
- Peptide Label: isoform 1
- UniProtKB: H7BX60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006525042   ⟸   XM_006524979
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006525041   ⟸   XM_006524978
- Peptide Label: isoform X1
- UniProtKB: H7BX60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006525043   ⟸   XM_006524980
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011244948   ⟸   XM_011246646
- Peptide Label: isoform X1
- UniProtKB: H7BX60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244947   ⟸   XM_011246645
- Peptide Label: isoform X1
- UniProtKB: H7BX60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030105924   ⟸   XM_030250064
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001361734   ⟸   NM_001374805
- Peptide Label: isoform 2
- UniProtKB: Q3TNS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000084089   ⟸   ENSMUST00000086876
RefSeq Acc Id: ENSMUSP00000156507   ⟸   ENSMUST00000233557
RefSeq Acc Id: ENSMUSP00000156746   ⟸   ENSMUST00000233972
RefSeq Acc Id: ENSMUSP00000156762   ⟸   ENSMUST00000233802
RefSeq Acc Id: XP_036016688   ⟸   XM_036160795
- Peptide Label: isoform X1
- UniProtKB: H7BX60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036016687   ⟸   XM_036160794
- Peptide Label: isoform X1
- UniProtKB: H7BX60 (UniProtKB/TrEMBL)
Protein Domains
Telomeric single stranded DNA binding POT1/Cdc13

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-H7BX60-F1-model_v2 AlphaFold H7BX60 1-640 view protein structure

Promoters
RGD ID:13676436
Promoter ID:EPDNEW_M22367
Type:single initiation site
Name:Pot1b_2
Description:Mus musculus protection of telomeres 1B , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22368  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381755,699,424 - 55,699,484EPDNEW
RGD ID:13676438
Promoter ID:EPDNEW_M22368
Type:initiation region
Name:Pot1b_1
Description:Mus musculus protection of telomeres 1B , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22367  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381755,712,624 - 55,712,684EPDNEW
RGD ID:6828490
Promoter ID:MM_KWN:23841
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung,   MEF_B6
Transcripts:NM_028370,   UC008DAC.1,   UC008DAD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361755,851,559 - 55,852,059 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920086 AgrOrtholog
Ensembl Genes ENSMUSG00000024174 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000086876 ENTREZGENE
  ENSMUST00000086876.7 UniProtKB/TrEMBL
  ENSMUST00000233557.2 UniProtKB/TrEMBL
  ENSMUST00000233802 ENTREZGENE
  ENSMUST00000233802.2 UniProtKB/TrEMBL
  ENSMUST00000233972 ENTREZGENE
  ENSMUST00000233972.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
InterPro NA-bd_OB-fold UniProtKB/TrEMBL
  POT1 UniProtKB/TrEMBL
  POT1_C_insert UniProtKB/TrEMBL
  POT1PC UniProtKB/TrEMBL
  Telomer_end-bd UniProtKB/TrEMBL
MGD MGI:1920086 ENTREZGENE
NCBI Gene 72836 ENTREZGENE
PANTHER PROTECTION OF TELOMERES PROTEIN 1 UniProtKB/TrEMBL
  PTHR14513 UniProtKB/TrEMBL
Pfam POT1_C_insert UniProtKB/TrEMBL
  POT1PC UniProtKB/TrEMBL
  Telo_bind UniProtKB/TrEMBL
PhenoGen Pot1b PhenoGen
SMART Telo_bind UniProtKB/TrEMBL
Superfamily-SCOP Nucleic_acid_OB UniProtKB/TrEMBL
UniProt A0A3B2WCG4_MOUSE UniProtKB/TrEMBL
  A0A3B2WCZ2_MOUSE UniProtKB/TrEMBL
  H7BX60 ENTREZGENE, UniProtKB/TrEMBL
  Q3TNS5 ENTREZGENE, UniProtKB/TrEMBL