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ONTOLOGY REPORT - ANNOTATIONS

Term:class II DNA-(apurinic or apyrimidinic site) endonuclease activity
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Accession:GO:0052720 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
Comment:Class II AP endonuclease is a nuclease, but not Class I, III and IV.
Synonyms:exact_synonym: class II DNA-(apurinic or apyrimidinic site) lyase activity
 alt_id: GO:0140079


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class II DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISS UniProt GO_REF:0000024 NCBI chr14:1,329,745...1,332,315
Ensembl chr14:19,381,911...19,384,542 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      catalytic activity, acting on a nucleic acid 593
        catalytic activity, acting on DNA 244
          DNA-(apurinic or apyrimidinic site) endonuclease activity 14
            class II DNA-(apurinic or apyrimidinic site) endonuclease activity 1
Path 2
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      hydrolase activity 2314
        hydrolase activity, acting on ester bonds 742
          nuclease activity 199
            DNA nuclease activity 64
              DNA endonuclease activity 42
                endodeoxyribonuclease activity, producing 5'-phosphomonoesters 13
                  class II DNA-(apurinic or apyrimidinic site) endonuclease activity 1
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