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ONTOLOGY REPORT - ANNOTATIONS

Term:endodeoxyribonuclease activity, producing 5'-phosphomonoesters
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Accession:GO:0016888 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
Synonyms:xref: EC:3.1.21;   reactome:R-HSA-912368 "SPO11 hydrolyzes DNA forming double-strand breaks"


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endodeoxyribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endov endonuclease V NOT|enables ISO (PMID:23139746), (PMID:23912683)
(PMID:12853604)		 RGD PMID:12853604 PMID:23139746 PMID:23912683 NCBI chr10:104,760,059...104,777,732
Ensembl chr10:104,760,137...104,775,969 		JBrowse link
5'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 enables ISS
IBA
IEA		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000104		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Exo1 exonuclease 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 enables ISO
IBA		 (PMID:20603015), (PMID:20603016), (PMID:20603073), (PMID:24981866)
GO_REF:0000033		 RGD
GO_Central		 PMID:20603015 PMID:20603016 PMID:20603073 PMID:24981866 GO_REF:0000033 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO
IBA		 (PMID:11986308), (PMID:18995831), (PMID:8621570)
GO_REF:0000033		 RGD
GO_Central		 PMID:8621570 PMID:11986308 PMID:18995831 GO_REF:0000033 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease enables ISO
IBA		 (PMID:26578604)
GO_REF:0000033		 RGD
GO_Central		 PMID:26578604 GO_REF:0000033 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr20:25,691,474...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19596235), (PMID:19596236)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:19596235 PMID:19596236 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
class II DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
ISS
IEA		 (PMID:11160897), (PMID:11286553), (PMID:1627644), (PMID:9804798)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:1627644 PMID:9804798 PMID:11160897 PMID:11286553 GO_REF:0000024 GO_REF:0000107 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
deoxyribonuclease I activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Dnase1 deoxyribonuclease 1 enables IDA
ISO
IBA		 (PMID:15015938)
GO_REF:0000033		 RGD
GO_Central		 PMID:15015938 PMID:12005024 GO_REF:0000033, RGD:1298888 NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869 		JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:152,056,942...152,065,518
Ensembl chr  X:152,056,942...152,065,518 		JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:13,471,850...13,473,447
Ensembl chr10:13,471,479...13,473,763 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      catalytic activity, acting on a nucleic acid 650
        catalytic activity, acting on DNA 283
          DNA nuclease activity 64
            DNA endonuclease activity 43
              endodeoxyribonuclease activity, producing 5'-phosphomonoesters 14
                5'-flap endonuclease activity 7
                CC-preferring endodeoxyribonuclease activity 0
                class II DNA-(apurinic or apyrimidinic site) endonuclease activity 1
                deoxyribonuclease I activity 5
                deoxyribonuclease IV (phage-T4-induced) activity 0
                deoxyribonuclease V activity 0
                type I site-specific deoxyribonuclease activity 0
                type II site-specific deoxyribonuclease activity 0
                type III site-specific deoxyribonuclease activity 0
Path 2
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      hydrolase activity 2585
        hydrolase activity, acting on ester bonds 814
          nuclease activity 228
            endonuclease activity 132
              DNA endonuclease activity 43
                endodeoxyribonuclease activity, producing 5'-phosphomonoesters 14
                  5'-flap endonuclease activity 7
                  CC-preferring endodeoxyribonuclease activity 0
                  class II DNA-(apurinic or apyrimidinic site) endonuclease activity 1
                  deoxyribonuclease I activity 5
                  deoxyribonuclease IV (phage-T4-induced) activity 0
                  deoxyribonuclease V activity 0
                  type I site-specific deoxyribonuclease activity 0
                  type II site-specific deoxyribonuclease activity 0
                  type III site-specific deoxyribonuclease activity 0
paths to the root