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Ontology Browser

Term:
endodeoxyribonuclease activity (GO:0004520)
Annotations: Rat: (44) Mouse: (39) Human: (43) Chinchilla: (39) Bonobo: (40) Dog: (33) Squirrel: (2) Pig: (32)
Parent Terms Term With Siblings Child Terms
endodeoxyribonuclease activity +   
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters +   
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters +   
endoribonuclease activity +   
exodeoxyribonuclease activity +   
oligodeoxyribonucleotidase activity 

Synonyms
Related Synonyms: DNA nicking activity ;   endonuclease G activity
Xrefs: reactome:R-HSA-110359 "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site" ;   reactome:R-HSA-5686440 "MUS81:EME1,EME2 cleaves D-loop" ;   reactome:R-HSA-5686657 "ERCC1:XPF cleaves flaps generated by SSA" ;   reactome:R-HSA-5687464 "MRN and RBBP8 resect DNA DSBs in MMEJ" ;   reactome:R-HSA-5690988 "3'-incision of DNA by ERCC5 (XPG) in GG-NER" ;   reactome:R-HSA-5693584 "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)" ;   reactome:R-HSA-5693608 "Initial resection of double-strand break ends" ;   reactome:R-HSA-6782204 "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER" ;   reactome:R-HSA-6782224 "3' incision by ERCC5 (XPG) in TC-NER" ;   reactome:R-HSA-9023941 "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11"
Definition Sources: GOC:mah, ISBN:0198547684

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.