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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA endonuclease activity
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Accession:GO:0004520 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
Synonyms:exact_synonym: endodeoxyribonuclease activity
 related_synonym: DNA nicking activity;   endonuclease G activity
 xref: reactome:R-HSA-110359 "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site";   reactome:R-HSA-5686440 "MUS81:EME1,EME2 cleaves D-loop";   reactome:R-HSA-5686657 "ERCC1:XPF cleaves flaps generated by SSA";   reactome:R-HSA-5687464 "MRN and RBBP8 resect DNA DSBs in MMEJ";   reactome:R-HSA-5690988 "3'-incision of DNA by ERCC5 (XPG) in GG-NER";   reactome:R-HSA-5693584 "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)";   reactome:R-HSA-5693608 "Initial resection of double-strand break ends";   reactome:R-HSA-6782204 "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER";   reactome:R-HSA-6782224 "3' incision by ERCC5 (XPG) in TC-NER";   reactome:R-HSA-9023941 "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11"


show annotations for term's descendants           Sort by:
DNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankle1 ankyrin repeat and LEM domain containing 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:18,076,413...18,082,356
Ensembl chr16:18,076,492...18,083,729 		JBrowse link
G Aplf aprataxin and PNKP like factor enables ISO (PMID:17396150) RGD PMID:17396150 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Dffb DNA fragmentation factor subunit beta enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 IDA RGD PMID:9665719 RGD:728743 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317 		JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal IDA RGD PMID:10558878 RGD:70721 NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376 		JBrowse link
G Dnase2b deoxyribonuclease 2 beta enables ISO (PMID:10497274) RGD PMID:10497274 NCBI chr 2:235,470,915...235,515,211
Ensembl chr 2:235,470,919...235,486,295 		JBrowse link
G Endog endonuclease G enables ISO (PMID:25355512), (PMID:29719607), (PMID:33473107)
(MGI:5617102|PMID:25355512), (MGI:6480170|PMID:32192768), (MGI:6810801|PMID:32095813)		 RGD PMID:25355512 PMID:29719607 PMID:32095813 PMID:32192768 PMID:33473107 MGI:5617102 MGI:6480170 MGI:6810801 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit contributes_to
enables		 ISO (PMID:8797827)
(PMID:10413517), (PMID:14734547), (PMID:17055345)		 RGD PMID:8797827 PMID:10413517 PMID:14734547 PMID:17055345 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease enables ISO
IBA		 (PMID:12644470), (PMID:8090225)
GO_REF:0000033		 RGD
GO_Central		 PMID:8090225 PMID:12644470 GO_REF:0000033 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000002
(PMID:22078559), (PMID:23080121), (PMID:24316220), (PMID:27814491), (PMID:27889449), (PMID:30787182), (PMID:9705271)		 UniProt
InterPro
RGD		 PMID:9705271 PMID:22078559 PMID:23080121 PMID:24316220 PMID:27814491 More... GO_REF:0000002 GO_REF:0000024 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G N4bp2 NEDD4 binding protein 2 enables ISO (PMID:12730195) RGD PMID:12730195 NCBI chr14:42,342,690...42,479,861
Ensembl chr14:42,409,510...42,483,960 		JBrowse link
G Rps3 ribosomal protein S3 enables ISO (PMID:15707971), (PMID:20605787) RGD PMID:15707971 PMID:20605787 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 enables ISO
IBA		 (PMID:22759634)
GO_REF:0000033		 RGD
GO_Central		 PMID:22759634 GO_REF:0000033 NCBI chr13:39,440,653...39,595,782
Ensembl chr13:39,440,889...39,595,670 		JBrowse link
3' overhang single-stranded DNA endodeoxyribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aste1 asteroid homolog 1 enables ISO
IEA		 (PMID:34354233)
GO_REF:0000107		 RGD
Ensembl		 PMID:34354233 GO_REF:0000107 NCBI chr 8:106,026,570...106,044,694
Ensembl chr 8:106,026,515...106,044,430 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit contributes_to ISO (PMID:14690602) RGD PMID:14690602 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit contributes_to ISO (PMID:14690602) RGD PMID:14690602 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 contributes_to ISO (MGI:3758502|PMID:14690602)
(PMID:14690602)		 RGD PMID:14690602 MGI:3758502 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 contributes_to ISO (MGI:3758502|PMID:14690602)
(PMID:14690602)		 RGD PMID:14690602 MGI:3758502 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
3'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mus81 MUS81 structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19595721)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:19595721 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
5'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 enables ISS
IBA
IEA		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000104		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Exo1 exonuclease 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 enables ISO
IBA		 (PMID:20603015), (PMID:20603016), (PMID:20603073), (PMID:24981866)
GO_REF:0000033		 RGD
GO_Central		 PMID:20603015 PMID:20603016 PMID:20603073 PMID:24981866 GO_REF:0000033 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO
IBA		 (PMID:11986308), (PMID:18995831), (PMID:8621570)
GO_REF:0000033		 RGD
GO_Central		 PMID:8621570 PMID:11986308 PMID:18995831 GO_REF:0000033 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease enables ISO
IBA		 (PMID:26578604)
GO_REF:0000033		 RGD
GO_Central		 PMID:26578604 GO_REF:0000033 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 enables IEA
IBA
ISS		 GO_REF:0000104
GO_REF:0000033
GO_REF:0000024		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr20:25,691,474...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19596235), (PMID:19596236)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:19596235 PMID:19596236 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
class II DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
ISS
IEA		 (PMID:11160897), (PMID:11286553), (PMID:1627644), (PMID:9804798)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:1627644 PMID:9804798 PMID:11160897 PMID:11286553 GO_REF:0000024 GO_REF:0000107 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
crossover junction DNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eme1 essential meiotic structure-specific endonuclease 1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:79,586,718...79,595,515
Ensembl chr10:79,586,729...79,595,435 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease enables ISO (PMID:23108668), (PMID:26578604), (PMID:26682650), (PMID:28049850) RGD PMID:23108668 PMID:26578604 PMID:26682650 PMID:28049850 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit enables
contributes_to		 IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
G Rad51c RAD51 paralog C contributes_to
enables		 ISO
IBA		 (PMID:14716019)
MGI:3707422|MGI:3707425 (PMID:17312021)
GO_REF:0000033		 RGD
GO_Central		 PMID:14716019 PMID:17312021 GO_REF:0000033 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19595721), (PMID:19596235), (PMID:19596236)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:19595721 PMID:19596235 PMID:19596236 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
G Tefm transcription elongation factor, mitochondrial NOT|enables ISO (PMID:21278163) RGD PMID:21278163 NCBI chr10:65,119,657...65,124,233
Ensembl chr10:65,119,659...65,124,486 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 contributes_to ISO (PMID:14716019), (PMID:23108668) RGD PMID:14716019 PMID:23108668 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
deoxyribonuclease I activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Dnase1 deoxyribonuclease 1 enables IDA
ISO
IBA		 (PMID:15015938)
GO_REF:0000033
(MGI:3687616|PMID:15015938)		 RGD
GO_Central		 PMID:15015938 PMID:12005024 GO_REF:0000033 MGI:3687616, RGD:1298888 NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869 		JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:152,056,942...152,065,518
Ensembl chr  X:152,056,942...152,065,518 		JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:13,471,850...13,473,447
Ensembl chr10:13,471,479...13,473,763 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317 		JBrowse link
deoxyribonuclease II activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnase2 deoxyribonuclease 2, lysosomal enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:11375492)
GO_REF:0000104		 GO_Central
RGD
UniProt		 PMID:11375492 GO_REF:0000033 GO_REF:0000104 NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376 		JBrowse link
G Dnase2b deoxyribonuclease 2 beta enables IDA
IEA
IBA		 GO_REF:0000104
GO_REF:0000033
GO_REF:0000003		 UniProt
GO_Central
RGD		 PMID:10558878 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104, RGD:70721 NCBI chr 2:235,470,915...235,515,211
Ensembl chr 2:235,470,919...235,486,295 		JBrowse link
double-stranded DNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rag1 recombination activating 1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
endodeoxyribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endov endonuclease V NOT|enables ISO (PMID:23139746), (PMID:23912683)
(PMID:12853604)
(MGI:5009179|PMID:12853604)		 RGD PMID:12853604 PMID:23139746 PMID:23912683 MGI:5009179 NCBI chr10:104,760,059...104,777,732
Ensembl chr10:104,760,137...104,775,969 		JBrowse link
flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exo1 exonuclease 1 enables ISO (PMID:10608837), (PMID:11842105) RGD PMID:10608837 PMID:11842105 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO (PMID:18499658)
(PMID:12162748)		 RGD PMID:12162748 PMID:18499658 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
single-stranded DNA endodeoxyribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aste1 asteroid homolog 1 enables ISO (PMID:34354233) RGD PMID:34354233 NCBI chr 8:106,026,570...106,044,694
Ensembl chr 8:106,026,515...106,044,430 		JBrowse link
G Dclre1c DNA cross-link repair 1C enables ISO
IEA		 (PMID:11955432)
GO_REF:0000107		 RGD
Ensembl		 PMID:11955432 GO_REF:0000107 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Endog endonuclease G enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit contributes_to ISO (PMID:7559382) RGD PMID:7559382 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Ercc4l1 excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:954,927...983,651
Ensembl chr10:954,977...983,174 		JBrowse link
G Exog exo/endonuclease G enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease enables ISO
IBA
IEA		 (PMID:9705271)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:9705271 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 IDA RGD PMID:12269805 RGD:633791 NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397 		JBrowse link
G Rad50 RAD50 double strand break repair protein contributes_to
enables		 ISO
IEA
ISS		 (PMID:9705271)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:9705271 GO_REF:0000024 GO_REF:0000107 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease enables ISO (PMID:18716619), (PMID:19202191) RGD PMID:18716619 PMID:19202191 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Setmar SET domain and mariner transposase fusion gene enables ISO (PMID:21491884), (PMID:24573677) RGD PMID:21491884 PMID:24573677 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
site-specific endodeoxyribonuclease activity, specific for altered base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19188445), (PMID:24703901)		 UniProt
Ensembl
RGD		 PMID:19188445 PMID:24703901 GO_REF:0000024 GO_REF:0000107 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 enables IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    catalytic activity 6109
      catalytic activity, acting on a nucleic acid 633
        catalytic activity, acting on DNA 256
          DNA nuclease activity 65
            DNA endonuclease activity 44
              DNA endonuclease activity, producing 3'-phosphomonoesters + 10
              T/G mismatch-specific endonuclease activity 0
              double-stranded DNA endonuclease activity + 1
              endodeoxyribonuclease activity, producing 5'-phosphomonoesters + 14
              excinuclease ABC activity 0
              flap endonuclease activity + 8
              restriction endodeoxyribonuclease activity + 0
              retroviral 3' processing activity 0
              single-stranded DNA endodeoxyribonuclease activity + 14
              site-specific endodeoxyribonuclease activity, specific for altered base + 2
Path 2
Term Annotations click to browse term
  molecular_function 20736
    catalytic activity 6109
      hydrolase activity 2583
        hydrolase activity, acting on ester bonds 813
          nuclease activity 229
            endonuclease activity 134
              DNA endonuclease activity 44
                DNA endonuclease activity, producing 3'-phosphomonoesters + 10
                T/G mismatch-specific endonuclease activity 0
                double-stranded DNA endonuclease activity + 1
                endodeoxyribonuclease activity, producing 5'-phosphomonoesters + 14
                excinuclease ABC activity 0
                flap endonuclease activity + 8
                restriction endodeoxyribonuclease activity + 0
                retroviral 3' processing activity 0
                single-stranded DNA endodeoxyribonuclease activity + 14
                site-specific endodeoxyribonuclease activity, specific for altered base + 2
paths to the root