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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of isotype switching to IgE isotypes
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Accession:GO:0048293 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes.
Synonyms:exact_synonym: regulation of class switch recombination to IgE isotypes;   regulation of class switching to IgE isotypes;   regulation of isotype switch recombination to IgE isotypes


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negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17137798) Ensembl
MGI		 PMID:17137798 GO_REF:0000107 NCBI chr 5:137,467,161...137,511,569
Ensembl chr 5:143,600,789...143,622,913 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) BHF-UCL PMID:12496423 MGI:3763508 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:62,722,611...62,734,279 JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14988498) TreeGrafter
MGI		 PMID:14988498 GO_REF:0000118 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 Ensembl chr12:32,068,679...32,085,099 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16447
    immune system process 2406
      production of molecular mediator of immune response 245
        immunoglobulin production 116
          regulation of immunoglobulin production 86
            regulation of isotype switching 40
              regulation of isotype switching to IgE isotypes 7
                negative regulation of isotype switching to IgE isotypes 3
                positive regulation of isotype switching to IgE isotypes + 4
                regulation of interleukin-4-dependent isotype switching to IgE isotypes + 1
Path 2
Term Annotations click to browse term
  biological_process 16447
    metabolic process 10323
      organic substance metabolic process 9890
        organic cyclic compound metabolic process 5563
          nucleobase-containing compound metabolic process 5105
            nucleic acid metabolic process 4608
              DNA metabolic process 904
                DNA recombination 322
                  somatic cell DNA recombination 77
                    somatic diversification of immune receptors via germline recombination within a single locus 77
                      somatic recombination of immunoglobulin gene segments 65
                        somatic recombination of immunoglobulin genes involved in immune response 57
                          isotype switching 57
                            isotype switching to IgE isotypes 7
                              regulation of isotype switching to IgE isotypes 7
                                negative regulation of isotype switching to IgE isotypes 3
                                positive regulation of isotype switching to IgE isotypes + 4
                                regulation of interleukin-4-dependent isotype switching to IgE isotypes + 1
paths to the root