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ONTOLOGY REPORT - ANNOTATIONS

Term:isotype switching to IgE isotypes
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Accession:GO:0048289 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:exact_synonym: class switch recombination to IgE isotypes;   class switching to IgE isotypes;   isotype switch recombination to IgE isotypes


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isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of ISO MGI:103034|MGI:2158438 (PMID:10490661) RGD PMID:10490661 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of ISO MGI:3696705 (PMID:16275384) RGD PMID:16275384 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (PMID:14988498) RGD PMID:14988498 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of ISO MGI:107187 (PMID:10490661) RGD PMID:10490661 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (PMID:10490661) RGD PMID:10490661 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (PMID:16275384) RGD PMID:16275384 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3695433 (PMID:17137798)		 Ensembl
RGD		 PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) RGD PMID:12496423 MGI:3763508 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 involved_in ISO (MGI:3777853|PMID:12023368) RGD PMID:12023368 MGI:3777853 NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:14988498) RGD PMID:14988498 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:107187 (PMID:10490661) RGD PMID:10490661 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    immune system process 3017
      leukocyte activation 1052
        lymphocyte activation 851
          lymphocyte activation involved in immune response 221
            B cell activation involved in immune response 96
              isotype switching 59
                isotype switching to IgE isotypes 7
                  interleukin-4-dependent isotype switching to IgE isotypes + 1
                  negative regulation of isotype switching to IgE isotypes 3
                  positive regulation of isotype switching to IgE isotypes + 4
                  regulation of isotype switching to IgE isotypes + 7
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      organic substance metabolic process 11328
        organic cyclic compound metabolic process 6260
          nucleobase-containing compound metabolic process 5743
            nucleic acid metabolic process 5144
              DNA metabolic process 991
                DNA recombination 358
                  somatic cell DNA recombination 79
                    somatic diversification of immune receptors via germline recombination within a single locus 79
                      somatic recombination of immunoglobulin gene segments 67
                        somatic recombination of immunoglobulin genes involved in immune response 59
                          isotype switching 59
                            isotype switching to IgE isotypes 7
                              interleukin-4-dependent isotype switching to IgE isotypes + 1
                              negative regulation of isotype switching to IgE isotypes 3
                              positive regulation of isotype switching to IgE isotypes + 4
                              regulation of isotype switching to IgE isotypes + 7
paths to the root