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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of isotype switching
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Accession:GO:0045830 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: positive regulation of class switch recombination;   positive regulation of class switching;   positive regulation of isotype switch recombination;   up regulation of isotype switching;   upregulation of isotype switching
 narrow_synonym: activation of isotype switching;   stimulation of isotype switching

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positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21255825) Ensembl
MGI		 PMID:21255825 GO_REF:0000107 NCBI chrNW_004936524:5,580,855...5,586,170
Ensembl chrNW_004936524:5,581,090...5,586,128 		JBrowse link
G Exosc6 exosome component 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21255825) Ensembl
MGI		 PMID:21255825 GO_REF:0000107 NCBI chrNW_004936475:23,295,441...23,297,321
Ensembl chrNW_004936475:23,295,500...23,296,318 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936798:261,566...284,480
Ensembl chrNW_004936798:261,661...273,011 		JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:1,928,172...1,983,983
Ensembl chrNW_004936599:1,928,145...1,984,008 		JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936886:596,949...602,959
Ensembl chrNW_004936886:595,782...604,286 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:538,703...542,901
Ensembl chrNW_004936474:538,625...542,901 		JBrowse link
G Paxip1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:9,440,129...9,488,215
Ensembl chrNW_004936527:9,440,036...9,484,245 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:26,045,500...26,105,980
Ensembl chrNW_004936469:26,048,953...26,105,997 		JBrowse link
G Shld1 shieldin complex subunit 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936485:13,179,218...13,267,980
Ensembl chrNW_004936485:13,176,426...13,267,953 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936601:5,315,297...5,400,752
Ensembl chrNW_004936601:5,315,261...5,396,301 		JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) UniProt PMID:29656893
G Tfrc transferrin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936784:696,738...728,385
Ensembl chrNW_004936784:696,713...728,543 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:6,589,395...6,668,242
Ensembl chrNW_004936471:6,589,564...6,668,305 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) BHF-UCL PMID:12496423 MGI:3763508 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101977665 tumor necrosis factor ligand superfamily member 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936595:831,252...839,783
Ensembl chrNW_004936595:830,466...839,748 		JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:26,556,636...26,600,830
Ensembl chrNW_004936473:26,556,611...26,603,736 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:4,943,987...5,013,356
Ensembl chrNW_004936508:4,944,007...5,013,356 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23241889) Ensembl
MGI		 PMID:23241889 GO_REF:0000107 NCBI chrNW_004936477:21,460,442...21,531,563
Ensembl chrNW_004936477:21,460,478...21,534,909 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004936750:439,396...468,747 JBrowse link
G Tgfb1 transforming growth factor beta 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
ISS		 (PMID:14988498) MGI
Ensembl
AgBase		 PMID:14988498 GO_REF:0000024 GO_REF:0000107 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
G Tnfsf13 TNF superfamily member 13 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14988498) MGI
TreeGrafter
Ensembl		 PMID:14988498 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936595:839,877...842,962
Ensembl chrNW_004936595:839,877...842,962 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin like cytokine factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:2,372,889...2,376,316
Ensembl chrNW_004936599:2,372,031...2,376,939 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chrNW_004936646:1,297,530...1,312,508
Ensembl chrNW_004936646:1,296,290...1,312,157 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25404367) Ensembl
MGI		 PMID:25404367 GO_REF:0000107 NCBI chrNW_004936538:2,815,370...2,877,084
Ensembl chrNW_004936538:2,811,174...2,874,113 		JBrowse link
G Cd28 CD28 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7688139) Ensembl
MGI		 PMID:7688139 GO_REF:0000107 NCBI chrNW_004936631:335,411...363,407
Ensembl chrNW_004936631:335,411...363,407 		JBrowse link
G Cd40 CD40 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12882831) Ensembl
MGI
TreeGrafter		 PMID:12882831 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936514:6,936,915...6,947,246
Ensembl chrNW_004936514:6,936,572...6,947,280 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Il2 interleukin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1830926) Ensembl
MGI		 PMID:1830926 GO_REF:0000107 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625 		JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:26,556,636...26,600,830
Ensembl chrNW_004936473:26,556,611...26,603,736 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:4,943,987...5,013,356
Ensembl chrNW_004936508:4,944,007...5,013,356 		JBrowse link
G Pagr1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 NCBI chrNW_004936501:12,657,092...12,660,106
Ensembl chrNW_004936501:12,656,435...12,660,067 		JBrowse link
G Paxip1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:9,440,129...9,488,215
Ensembl chrNW_004936527:9,440,036...9,484,245 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004936750:439,396...468,747 JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9015183) Ensembl
MGI		 PMID:9015183 GO_REF:0000107 NCBI chrNW_004936567:5,266,653...5,378,464
Ensembl chrNW_004936567:5,267,615...5,378,258 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12882831) Ensembl
MGI		 PMID:12882831 GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15971
    developmental process 6338
      positive regulation of developmental process 1412
        positive regulation of isotype switching 31
          positive regulation of isotype switching to IgA isotypes 7
          positive regulation of isotype switching to IgD isotypes 0
          positive regulation of isotype switching to IgE isotypes + 3
          positive regulation of isotype switching to IgG isotypes 12
Path 2
Term Annotations click to browse term
  biological_process 15971
    metabolic process 9633
      organic substance metabolic process 9208
        organic cyclic compound metabolic process 5208
          nucleobase-containing compound metabolic process 4758
            nucleic acid metabolic process 4278
              DNA metabolic process 875
                DNA recombination 311
                  somatic cell DNA recombination 76
                    somatic diversification of immune receptors via germline recombination within a single locus 76
                      somatic recombination of immunoglobulin gene segments 64
                        somatic recombination of immunoglobulin genes involved in immune response 56
                          isotype switching 56
                            regulation of isotype switching 39
                              positive regulation of isotype switching 31
                                positive regulation of isotype switching to IgA isotypes 7
                                positive regulation of isotype switching to IgD isotypes 0
                                positive regulation of isotype switching to IgE isotypes + 3
                                positive regulation of isotype switching to IgG isotypes 12
paths to the root