Shld2 (shieldin complex subunit 2)

Gene: Shld2 (shieldin complex subunit 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Shld2

Name:

shieldin complex subunit 2

RGD ID:

12730783

Description:

INVOLVED IN negative regulation of double-strand break repair via homologous recombination (inferred); positive regulation of double-strand break repair via nonhomologous end joining (inferred); positive regulation of isotype switching (inferred); ASSOCIATED WITH diabetes mellitus (ortholog); familial hyperinsulinemic hypoglycemia 6 (ortholog); genetic disease (ortholog); FOUND IN actin cytoskeleton (inferred); chromosome (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Fam35a; family with sequence similarity 35 member A

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	43,682,657 - 43,768,173 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936601	5,315,261 - 5,396,301 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936601	5,315,297 - 5,400,752 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

diabetes mellitus (ISO)

familial hyperinsulinemic hypoglycemia 6 (ISO)

genetic disease (ISO)

hyperinsulinism (ISO)

juvenile polyposis syndrome (ISO)

PTEN hamartoma tumor syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of double-strand break repair via homologous recombination (IEA)

positive regulation of double-strand break repair via nonhomologous end joining (IEA)

positive regulation of isotype switching (IEA)

regulation of double-strand break repair via homologous recombination (IEA)

Cellular Component

actin cytoskeleton (IEA)

chromosome (IEA)

nucleoplasm (IEA)

nucleus (IEA)

site of double-strand break (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Shld2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	43,682,657 - 43,768,173 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936601	5,315,261 - 5,396,301 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936601	5,315,297 - 5,400,752 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SHLD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	87,094,473 - 87,191,465 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	87,094,161 - 87,191,465 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	88,854,963 - 88,951,222 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	88,844,933 - 88,941,202 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	88,844,932 - 88,941,200	NCBI
Cytogenetic Map	10	q23.2	NCBI
HuRef	10	82,778,394 - 82,789,042 (+)	NCBI		HuRef
CHM1_1	10	89,136,724 - 89,232,977 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	87,978,839 - 88,075,088 (+)	NCBI		T2T-CHM13v2.0

Shld2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	33,958,905 - 34,032,528 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	33,958,990 - 34,032,450 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	34,236,948 - 34,310,651 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	34,237,033 - 34,310,493 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	35,050,219 - 35,123,689 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	33,066,133 - 33,139,458 (-)	NCBI		MGSCv36	mm8
Celera	14	30,499,098 - 30,576,001 (-)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	20.8	NCBI

Shld2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	9,554,921 - 9,646,186 (-)	NCBI		GRCr8
mRatBN7.2	16	9,544,940 - 9,640,323 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	9,548,660 - 9,639,965 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	9,562,132 - 9,660,662 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	10,706,838 - 10,805,376 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	9,557,197 - 9,655,744 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	10,570,307 - 10,661,528 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	10,570,314 - 10,661,528 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	8,888,929 - 8,979,969 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	9,868,212 - 9,965,225 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	5,576,833 - 5,667,636 (+)	NCBI		Celera
Cytogenetic Map	16	p15	NCBI

Shld2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955510	6,075,510 - 6,114,898 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955510	6,021,477 - 6,114,745 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC103784056
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	59,311,152 - 59,353,528 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	59,316,469 - 59,359,047 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	43,572,547 - 43,624,201 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	87,923,049 - 87,928,101 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

SHLD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	34,665,111 - 34,740,645 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	34,688,245 - 34,763,705 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	34,654,858 - 34,732,283 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	35,023,800 - 35,101,252 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	4	34,869,031 - 34,946,347 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	35,038,013 - 35,115,455 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	35,544,430 - 35,621,946 (+)	NCBI		UU_Cfam_GSD_1.0

SHLD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	88,005,611 - 88,121,352 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	88,005,599 - 88,121,155 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	95,538,054 - 95,600,923 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SHLD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	44,565,105 - 44,652,926 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	44,564,792 - 44,605,562 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	4,377,310 - 4,464,557 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Shld2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624841	20,431 - 133,163 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624841	21,077 - 133,155 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005333752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021731960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021731961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040271940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040271941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000027977 ⟹ ENSSTOP00000021145

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936601	5,315,261 - 5,356,322 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000029597 ⟹ ENSSTOP00000020805

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936601	5,315,261 - 5,396,301 (-)	Ensembl

RefSeq Acc Id:

XM_005333752 ⟹ XP_005333809

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	43,682,657 - 43,724,603 (-)	NCBI
SpeTri2.0	NW_004936601	5,315,297 - 5,357,176 (-)	NCBI

Sequence:

show sequence

CCTGCCTCAGCTTGCTGAGTTGCTGGCATTACAGAAAAATTTGATTCATTATTATGGATTTGTG
AAATATATATAGATCTATAAAGGACAGTATAATGAACTCCATGTAATGATCACCTGACTTCAGG
GCTTTCTATTTTGCAGTTTTGTTTGTGCCTTCTATTTTGGTTTTGGGAATTGAGTTCACAGTTC
AAAGAAGGAGACTCAAAACTACTGAGATAATCTATGGAATAAAGAAAACAGAAATTATGAGTGG
AGGATCTCAAGTCCACATTTTTTGGGGTGCTCCAGCTAGTCCACTGGAAATGACAGTATCACAG
AGAACAACTTTAATGTCCACTGCAGACCCCTGGAAAAAATTTCAACTTTGGTACAATCAGCATT
CTTTGCATCTGAAGGACGAAAACCATGAGCCAAACAATCTCAAAGACTATCAAGTCTCAGAAGC
TATTACTGGCCCTCCAGATCTTTTAAGTGGTTGTTGTTTAGTGAATTCTATGAGTAGATCTGTT
CAAGTTAAAGATGATTTTACATACTTTACTTCAGAAACACAGAATATAAAATCCCAGAAGATTT
ACCCTTCAGGGCTGAGTGACGTAACTAATTCTAATGTGCAAATACACGGATTTAAGGGCACAGT
TCAGCATTTACCTGAAGAAAAAAAGAATCAAAAGGTTCAATGTGAAAATAATAAAATTACAGAT
GAAGAGCCTAAAAATCAATCAAACTTATGTCAAAACTTTCAAACAAATTCCTTTCAGTTAGATC
ATAAATGTGCAGTTACATTGGATTTGGTTGGTAGTACTAAACAAACTAATACAGATCTTGAAGC
TATAGAAACAAAGTACAAGCCAACAGAACACCATGAAATGCAAAACCAGTGTCTGGACTTCTTT
TCCTCTAATGCAGTAGATGAGCCAAGGTCTGATAGAGCAGTTAGGAATGTCTCAAACCTTAAAA
TATCTACTGACACTGAATTTCTGAGAATAATGATCTCCAGCCAGGTTGCTTTTTTAGCTCAAAG
GGAGGATAGAGCTCTGAATTCTATAAATAAAGGGACCATAAGCATGGAAACTGAACCAAAGGCA
AGTCATGGGGAAATAAGAATAACTGAAGATAGTTTTATTCAGCCTAATGATGATTTTGCAGAAG
GACATGAAAGAGGACAAAATGAAGAAACATATTCCTTAGAACTTTTTAGTCCTATTTGTCCTGA
AAAAAAAAGTAGCCACATTCACATAAACCCTGAAAAAGATGTTGAAGAAAATATAGAATCTCAA
AAACTTTTCAGTTCTGAAGATAAACTGTCACCAAATGAGATCTGTATTGAGTTGTGTCGCTCAG
GAACACAGTGTTCCCAACTGAATACCTTTCACAAAAGTGCTGTTAAAAGAAATTGGAGCTCTGA
AGATAAATCAGGCAATTCCAAAGCTCTGTCTAAAGTCCTCCAAGTATCTAAGAAAATGAAGTTG
GGTTCTAATGCAAGAGATTCTATCATAGCAATGAGCCAGAGGAATGTGTCTGAATTTAAGGGTA
TTAAAAAAATATCATTAATAAAAAATTGTGATTCTAAAAGTCAGAAGTATAATTGTTTAGCTAT
GGTGCTAACTCCAAGTCAGATGAAAGAAATAAACATAAAATCTGGACCCAATTCTGGATCTAAA
GTGCCTTTAGCAACAATTATAGTAATTGATCAATCAGAAATTAAGAAGAAGGTTTTTCTGTGGA
GAACTGCTGCATTTTGGGCACTTACAGTATTTCTGGGAGATATAATTTTACTCACAGATGTTGT
TATTCATGAGGATCAATGGATTGGTGAGATAATACTCCAATCAACATTCACAAGTCAGTTATTA
AATCTTGGGAATTATTCATCTGTACAGCCAGAAGAATATTCCAATATAGTTAGTGATGTTGCAC
TTCAGGATTTACTGGCATATGTGTCTTCAAAACATTTCTATCTTGAAGATCTTCCACAGAGGCA
GCCTCAGAAAGTGAACAGTATAGAGTTTGTAGAATTGGAGCAACTACAACCTGATAGATTAGTC
CATGCAGTACTAAGAATTGTGGATATCACTATACTGACAGAGTCATTATACACTTACAGAGGAC
AAAAGCAAAGGAAAGTTATGTTAACAGTGGAACAGGCCCAAGGTCAACACTATGTGCTTGTATT
ATGGGGTCTTGGAGCAGCCTGGTACCCTCAACTTCAAAGGAAAAAAGATTATATTTGGGAATTT
AAATATCTTTTGGTTCAGCACAACTGCACACTGGAAACCCTAGAGTTGCATACAACGCCTTGGT
CATCCTGTGAATGTCTGTTTGATGATGATATAAGGGCAGTTACATTTAAAACAAAATTTCAAAA
TAGTGTACCTACTTTTGTCAAGATGTCAGATTTAGCGGCACACTTAAAGGATAAGTATTCAGGA
GTAGTTCTAATTAAAGCTCAAATTTTAGAGCTAGTATTTCCTGTTGCAGCAGCTCAGAAGATAA
CTCTAAATGCTCACTGTTCCCTGAAGAGTATCTTCTCCTCTCTCCCCCACATTATATATACTGG
CTGTGCAAAATGTGGATTGGAACTAGAAACAGATGAAAACAAAATCTACAGACAGTGTCTTAGC
TGCTTGCCATTTGCTAAGAAGAAAACACATTATAGGCCAGCTTTAATGACTGTAGCTGATGGAA
CACATAACATTTGCATCCATGTAGGATCAGAGTTAATAGAGAAGATTCTTCTCAACATTTCTCC
AGACTGCCTCAACAGAATTGTAGTACCTTCTTCAGAGATCACCTATGGAATGGTTGCAGCAGAC
CTGCTTCTCTCCTTGTTGATGGATAGCACAGAGCCTTGTGTATTGAAGATTCAGAGCCTTTTTG
TCTTAGATGAAAATAGTTACCCATTGCAACAGGATTTCTCCCTACTGGATTTCTGTCCTGGTCA
ATGTAAGGCATGGAGCCCTTCTCTGAGGCCACATGAGGAAGTTGTAGACATTCCAAAGAAGAAG
TACTGAAATGATTTGTGTTTTAAATGAATGATAGGGGTTTTGCTTTGGGCTTGTTTTATATATA
TATATATAAAATAAAGAAAATTGTGC

hide sequence

RefSeq Acc Id:

XM_021731960 ⟹ XP_021587635

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	43,682,657 - 43,728,031 (-)	NCBI
SpeTri2.0	NW_004936601	5,315,297 - 5,360,608 (-)	NCBI

Sequence:

show sequence

CTCTTGTCTTAGATTCTTGAGTATCTGGGACTACAGAAAAATTTGATTCATTATTATGGATTTG
TGAAATATATATAGATCTATAAAGGACAGTATAATGAACTCCATGTAATGATCACCTGACTTCA
GGGCTTTCTATTTTGCAGTTTTGTTTGTGCCTTCTATTTTGGTTTTGGGAATTGAGTTCACAGT
TCAAAGAAGGAGACTCAAAACTACTGAGATAATCTATGGAATAAAGAAAACAGAAATTATGAGT
GGAGGATCTCAAGTCCACATTTTTTGGGGTGCTCCAGCTAGTCCACTGGAAATGACAGTATCAC
AGAGAACAACTTTAATGTCCACTGCAGACCCCTGGAAAAAATTTCAACTTTGGTACAATCAGCA
TTCTTTGCATCTGAAGGACGAAAACCATGAGCCAAACAATCTCAAAGACTATCAAGTCTCAGAA
GCTATTACTGGCCCTCCAGATCTTTTAAGTGGTTGTTGTTTAGTGAATTCTATGAGTAGATCTG
TTCAAGTTAAAGATGATTTTACATACTTTACTTCAGAAACACAGAATATAAAATCCCAGAAGAT
TTACCCTTCAGGGCTGAGTGACGTAACTAATTCTAATGTGCAAATACACGGATTTAAGGGCACA
GTTCAGCATTTACCTGAAGAAAAAAAGAATCAAAAGGTTCAATGTGAAAATAATAAAATTACAG
ATGAAGAGCCTAAAAATCAATCAAACTTATGTCAAAACTTTCAAACAAATTCCTTTCAGTTAGA
TCATAAATGTGCAGTTACATTGGATTTGGTTGGTAGTACTAAACAAACTAATACAGATCTTGAA
GCTATAGAAACAAAGTACAAGCCAACAGAACACCATGAAATGCAAAACCAGTGTCTGGACTTCT
TTTCCTCTAATGCAGTAGATGAGCCAAGGTCTGATAGAGCAGTTAGGAATGTCTCAAACCTTAA
AATATCTACTGACACTGAATTTCTGAGAATAATGATCTCCAGCCAGGTTGCTTTTTTAGCTCAA
AGGGAGGATAGAGCTCTGAATTCTATAAATAAAGGGACCATAAGCATGGAAACTGAACCAAAGG
CAAGTCATGGGGAAATAAGAATAACTGAAGATAGTTTTATTCAGCCTAATGATGATTTTGCAGA
AGGACATGAAAGAGGACAAAATGAAGAAACATATTCCTTAGAACTTTTTAGTCCTATTTGTCCT
GAAAAAAAAAGTAGCCACATTCACATAAACCCTGAAAAAGATGTTGAAGAAAATATAGAATCTC
AAAAACTTTTCAGTTCTGAAGATAAACTGTCACCAAATGAGATCTGTATTGAGTTGTGTCGCTC
AGGAACACAGTGTTCCCAACTGAATACCTTTCACAAAAGTGCTGTTAAAAGAAATTGGAGCTCT
GAAGATAAATCAGGCAATTCCAAAGCTCTGTCTAAAGTCCTCCAAGTATCTAAGAAAATGAAGT
TGGGTTCTAATGCAAGAGATTCTATCATAGCAATGAGCCAGAGGAATGTGTCTGAATTTAAGGG
TATTAAAAAAATATCATTAATAAAAAATTGTGATTCTAAAAGTCAGAAGTATAATTGTTTAGCT
ATGGTGCTAACTCCAAGTCAGATGAAAGAAATAAACATAAAATCTGGACCCAATTCTGGATCTA
AAGTGCCTTTAGCAACAATTATAGTAATTGATCAATCAGAAATTAAGAAGAAGGTTTTTCTGTG
GAGAACTGCTGCATTTTGGGCACTTACAGTATTTCTGGGAGATATAATTTTACTCACAGATGTT
GTTATTCATGAGGATCAATGGATTGGTGAGATAATACTCCAATCAACATTCACAAGTCAGTTAT
TAAATCTTGGGAATTATTCATCTGTACAGCCAGAAGAATATTCCAATATAGTTAGTGATGTTGC
ACTTCAGGATTTACTGGCATATGTGTCTTCAAAACATTTCTATCTTGAAGATCTTCCACAGAGG
CAGCCTCAGAAAGTGAACAGTATAGAGTTTGTAGAATTGGAGCAACTACAACCTGATAGATTAG
TCCATGCAGTACTAAGAATTGTGGATATCACTATACTGACAGAGTCATTATACACTTACAGAGG
ACAAAAGCAAAGGAAAGTTATGTTAACAGTGGAACAGGCCCAAGGTCAACACTATGTGCTTGTA
TTATGGGGTCTTGGAGCAGCCTGGTACCCTCAACTTCAAAGGAAAAAAGATTATATTTGGGAAT
TTAAATATCTTTTGGTTCAGCACAACTGCACACTGGAAACCCTAGAGTTGCATACAACGCCTTG
GTCATCCTGTGAATGTCTGTTTGATGATGATATAAGGGCAGTTACATTTAAAACAAAATTTCAA
AATAGTGTACCTACTTTTGTCAAGATGTCAGATTTAGCGGCACACTTAAAGGATAAGTATTCAG
GAGTAGTTCTAATTAAAGCTCAAATTTTAGAGCTAGTATTTCCTGTTGCAGCAGCTCAGAAGAT
AACTCTAAATGCTCACTGTTCCCTGAAGAGTATCTTCTCCTCTCTCCCCCACATTATATATACT
GGCTGTGCAAAATGTGGATTGGAACTAGAAACAGATGAAAACAAAATCTACAGACAGTGTCTTA
GCTGCTTGCCATTTGCTAAGAAGAAAACACATTATAGGCCAGCTTTAATGACTGTAGCTGATGG
AACACATAACATTTGCATCCATGTAGGATCAGAGTTAATAGAGAAGATTCTTCTCAACATTTCT
CCAGACTGCCTCAACAGAATTGTAGTACCTTCTTCAGAGATCACCTATGGAATGGTTGCAGCAG
ACCTGCTTCTCTCCTTGTTGATGGATAGCACAGAGCCTTGTGTATTGAAGATTCAGAGCCTTTT
TGTCTTAGATGAAAATAGTTACCCATTGCAACAGGATTTCTCCCTACTGGATTTCTGTCCTGGT
CAATGTAAGGCATGGAGCCCTTCTCTGAGGCCACATGAGGAAGTTGTAGACATTCCAAAGAAGA
AGTACTGAAATGATTTGTGTTTTAAATGAATGATAGGGGTTTTGCTTTGGGCTTGTTTTATATA
TATATATATAAAATAAAGAAAATTGTGC

hide sequence

RefSeq Acc Id:

XM_021731961 ⟹ XP_021587636

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	43,682,657 - 43,768,173 (-)	NCBI
SpeTri2.0	NW_004936601	5,315,297 - 5,400,752 (-)	NCBI

Sequence:

show sequence

TGGAGGTCTGGCCGCGGGCCCGGGGCGTCTTAGTCATGTTTCCGTCCGCCTGCTAAGGGGCGCC
CTGGGGCCGGAACCAGTGATGCGGGGCTCAGGCGCTTGAGGCCGGAAAGCGATGCGGAGCAGAG
GGTGTTGAGGTCTGGCTCAGGGCTGGGTCTCCACCCGGGGTGAGGAAAGTTTTCATCACTAGTG
GAACTGAGAGGAACTATGAAGGAGAAGGTCGCGGGGCTGGGGAATCCCTGACCAACTGGCTTTT
ACTACCCACGTTTTTAATTTGTCCCGTTCTACTAAAAGACATCGAGATAAAAGTTACGCAAAGC
ACTGTTGCCTTCCTCGATTCGTTCATGTCTAAAACGTGAAATAGTCTAAAACAAGGCAATGTGG
AAATGCGATTATGCTCAGGAATAAATAAATAAGTAGGAAATGCTAAATCTAATGCACTTCTTTA
AATAAGATGTTTGAAAGAGCCTAATGACTCAGTCATTAAAGAAAGCTACCAAATGCCACATGAC
CATCTGTAGTGGTCCCATAATATTTTGGCGGTTTTTAAATGTCATCTTTTTGTATTTCCTGAAA
TTCATCTATTAGATAACTTCATTCATCTATTAGAATATGAAAGAAAAATAAGTCTCACAAGATT
CTGTAAAGTATATTCTTATGTTTTTCAGCAGAAAAGAGACCAGTATCCTGAATTTATTTTGATG
GTCAAAAAGTTAAAGTGAACAAGCTTTTGTAATAAGCCAAATAACAACAAAAAGAGTTGTATCA
AAGAAAAGGATCTGAAGTTTTCAAGTTTGTGCCTTCTATTTTGGTTTTGGGAATTGAGTTCACA
GTTCAAAGAAGGAGACTCAAAACTACTGAGATAATCTATGGAATAAAGAAAACAGAAATTATGA
GTGGAGGATCTCAAGTCCACATTTTTTGGGGTGCTCCAGCTAGTCCACTGGAAATGACAGTATC
ACAGAGAACAACTTTAATGTCCACTGCAGACCCCTGGAAAAAATTTCAACTTTGGTACAATCAG
CATTCTTTGCATCTGAAGGACGAAAACCATGAGCCAAACAATCTCAAAGACTATCAAGTCTCAG
AAGCTATTACTGGCCCTCCAGATCTTTTAAGTGGTTGTTGTTTAGTGAATTCTATGAGTAGATC
TGTTCAAGTTAAAGATGATTTTACATACTTTACTTCAGAAACACAGAATATAAAATCCCAGAAG
ATTTACCCTTCAGGGCTGAGTGACGTAACTAATTCTAATGTGCAAATACACGGATTTAAGGGCA
CAGTTCAGCATTTACCTGAAGAAAAAAAGAATCAAAAGGTTCAATGTGAAAATAATAAAATTAC
AGATGAAGAGCCTAAAAATCAATCAAACTTATGTCAAAACTTTCAAACAAATTCCTTTCAGTTA
GATCATAAATGTGCAGTTACATTGGATTTGGTTGGTAGTACTAAACAAACTAATACAGATCTTG
AAGCTATAGAAACAAAGTACAAGCCAACAGAACACCATGAAATGCAAAACCAGTGTCTGGACTT
CTTTTCCTCTAATGCAGTAGATGAGCCAAGGTCTGATAGAGCAGTTAGGAATGTCTCAAACCTT
AAAATATCTACTGACACTGAATTTCTGAGAATAATGATCTCCAGCCAGGTTGCTTTTTTAGCTC
AAAGGGAGGATAGAGCTCTGAATTCTATAAATAAAGGGACCATAAGCATGGAAACTGAACCAAA
GGCAAGTCATGGGGAAATAAGAATAACTGAAGATAGTTTTATTCAGCCTAATGATGATTTTGCA
GAAGGACATGAAAGAGGACAAAATGAAGAAACATATTCCTTAGAACTTTTTAGTCCTATTTGTC
CTGAAAAAAAAAGTAGCCACATTCACATAAACCCTGAAAAAGATGTTGAAGAAAATATAGAATC
TCAAAAACTTTTCAGTTCTGAAGATAAACTGTCACCAAATGAGATCTGTATTGAGTTGTGTCGC
TCAGGAACACAGTGTTCCCAACTGAATACCTTTCACAAAAGTGCTGTTAAAAGAAATTGGAGCT
CTGAAGATAAATCAGGCAATTCCAAAGCTCTGTCTAAAGTCCTCCAAGTATCTAAGAAAATGAA
GTTGGGTTCTAATGCAAGAGATTCTATCATAGCAATGAGCCAGAGGAATGTGTCTGAATTTAAG
GGTATTAAAAAAATATCATTAATAAAAAATTGTGATTCTAAAAGTCAGAAGTATAATTGTTTAG
CTATGGTGCTAACTCCAAGTCAGATGAAAGAAATAAACATAAAATCTGGACCCAATTCTGGATC
TAAAGTGCCTTTAGCAACAATTATAGTAATTGATCAATCAGAAATTAAGAAGAAGGTTTTTCTG
TGGAGAACTGCTGCATTTTGGGCACTTACAGTATTTCTGGGAGATATAATTTTACTCACAGATG
TTGTTATTCATGAGGATCAATGGATTGGTGAGATAATACTCCAATCAACATTCACAAGTCAGTT
ATTAAATCTTGGGAATTATTCATCTGTACAGCCAGAAGAATATTCCAATATAGTTAGTGATGTT
GCACTTCAGGATTTACTGGCATATGTGTCTTCAAAACATTTCTATCTTGAAGATCTTCCACAGA
GGCAGCCTCAGAAAGTGAACAGTATAGAGTTTGTAGAATTGGAGCAACTACAACCTGATAGATT
AGTCCATGCAGTACTAAGAATTGTGGATATCACTATACTGACAGAGTCATTATACACTTACAGA
GGACAAAAGCAAAGGAAAGTTATGTTAACAGTGGAACAGGCCCAAGGTCAACACTATGTGCTTG
TATTATGGGGTCTTGGAGCAGCCTGGTACCCTCAACTTCAAAGGAAAAAAGATTATATTTGGGA
ATTTAAATATCTTTTGGTTCAGCACAACTGCACACTGGAAACCCTAGAGTTGCATACAACGCCT
TGGTCATCCTGTGAATGTCTGTTTGATGATGATATAAGGGCAGTTACATTTAAAACAAAATTTC
AAAATAGTGTACCTACTTTTGTCAAGATGTCAGATTTAGCGGCACACTTAAAGGATAAGTATTC
AGGAGTAGTTCTAATTAAAGCTCAAATTTTAGAGCTAGTATTTCCTGTTGCAGCAGCTCAGAAG
ATAACTCTAAATGCTCACTGTTCCCTGAAGAGTATCTTCTCCTCTCTCCCCCACATTATATATA
CTGGCTGTGCAAAATGTGGATTGGAACTAGAAACAGATGAAAACAAAATCTACAGACAGTGTCT
TAGCTGCTTGCCATTTGCTAAGAAGAAAACACATTATAGGCCAGCTTTAATGACTGTAGCTGAT
GGAACACATAACATTTGCATCCATGTAGGATCAGAGTTAATAGAGAAGATTCTTCTCAACATTT
CTCCAGACTGCCTCAACAGAATTGTAGTACCTTCTTCAGAGATCACCTATGGAATGGTTGCAGC
AGACCTGCTTCTCTCCTTGTTGATGGATAGCACAGAGCCTTGTGTATTGAAGATTCAGAGCCTT
TTTGTCTTAGATGAAAATAGTTACCCATTGCAACAGGATTTCTCCCTACTGGATTTCTGTCCTG
GTCAATGTAAGGCATGGAGCCCTTCTCTGAGGCCACATGAGGAAGTTGTAGACATTCCAAAGAA
GAAGTACTGAAATGATTTGTGTTTTAAATGAATGATAGGGGTTTTGCTTTGGGCTTGTTTTATA
TATATATATATAAAATAAAGAAAATTGTGC

hide sequence

RefSeq Acc Id:

XM_040271940 ⟹ XP_040127874

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	43,682,657 - 43,768,173 (-)	NCBI

RefSeq Acc Id:

XM_040271941 ⟹ XP_040127875

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	43,682,657 - 43,728,006 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005333809	(Get FASTA)	NCBI Sequence Viewer
	XP_021587635	(Get FASTA)	NCBI Sequence Viewer
	XP_021587636	(Get FASTA)	NCBI Sequence Viewer
	XP_040127874	(Get FASTA)	NCBI Sequence Viewer
	XP_040127875	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000020805.2
	ENSSTOP00000021145.2

RefSeq Acc Id:

XP_005333809 ⟸ XM_005333752

- UniProtKB:

I3N9U8 (UniProtKB/TrEMBL), I3N8V9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGGSQVHIFWGAPASPLEMTVSQRTTLMSTADPWKKFQLWYNQHSLHLKDENHEPNNLKDYQV
SEAITGPPDLLSGCCLVNSMSRSVQVKDDFTYFTSETQNIKSQKIYPSGLSDVTNSNVQIHGFK
GTVQHLPEEKKNQKVQCENNKITDEEPKNQSNLCQNFQTNSFQLDHKCAVTLDLVGSTKQTNTD
LEAIETKYKPTEHHEMQNQCLDFFSSNAVDEPRSDRAVRNVSNLKISTDTEFLRIMISSQVAFL
AQREDRALNSINKGTISMETEPKASHGEIRITEDSFIQPNDDFAEGHERGQNEETYSLELFSPI
CPEKKSSHIHINPEKDVEENIESQKLFSSEDKLSPNEICIELCRSGTQCSQLNTFHKSAVKRNW
SSEDKSGNSKALSKVLQVSKKMKLGSNARDSIIAMSQRNVSEFKGIKKISLIKNCDSKSQKYNC
LAMVLTPSQMKEINIKSGPNSGSKVPLATIIVIDQSEIKKKVFLWRTAAFWALTVFLGDIILLT
DVVIHEDQWIGEIILQSTFTSQLLNLGNYSSVQPEEYSNIVSDVALQDLLAYVSSKHFYLEDLP
QRQPQKVNSIEFVELEQLQPDRLVHAVLRIVDITILTESLYTYRGQKQRKVMLTVEQAQGQHYV
LVLWGLGAAWYPQLQRKKDYIWEFKYLLVQHNCTLETLELHTTPWSSCECLFDDDIRAVTFKTK
FQNSVPTFVKMSDLAAHLKDKYSGVVLIKAQILELVFPVAAAQKITLNAHCSLKSIFSSLPHII
YTGCAKCGLELETDENKIYRQCLSCLPFAKKKTHYRPALMTVADGTHNICIHVGSELIEKILLN
ISPDCLNRIVVPSSEITYGMVAADLLLSLLMDSTEPCVLKIQSLFVLDENSYPLQQDFSLLDFC
PGQCKAWSPSLRPHEEVVDIPKKKY

hide sequence

RefSeq Acc Id:

XP_021587636 ⟸ XM_021731961

- UniProtKB:

I3N8V9 (UniProtKB/TrEMBL), I3N9U8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGGSQVHIFWGAPASPLEMTVSQRTTLMSTADPWKKFQLWYNQHSLHLKDENHEPNNLKDYQV
SEAITGPPDLLSGCCLVNSMSRSVQVKDDFTYFTSETQNIKSQKIYPSGLSDVTNSNVQIHGFK
GTVQHLPEEKKNQKVQCENNKITDEEPKNQSNLCQNFQTNSFQLDHKCAVTLDLVGSTKQTNTD
LEAIETKYKPTEHHEMQNQCLDFFSSNAVDEPRSDRAVRNVSNLKISTDTEFLRIMISSQVAFL
AQREDRALNSINKGTISMETEPKASHGEIRITEDSFIQPNDDFAEGHERGQNEETYSLELFSPI
CPEKKSSHIHINPEKDVEENIESQKLFSSEDKLSPNEICIELCRSGTQCSQLNTFHKSAVKRNW
SSEDKSGNSKALSKVLQVSKKMKLGSNARDSIIAMSQRNVSEFKGIKKISLIKNCDSKSQKYNC
LAMVLTPSQMKEINIKSGPNSGSKVPLATIIVIDQSEIKKKVFLWRTAAFWALTVFLGDIILLT
DVVIHEDQWIGEIILQSTFTSQLLNLGNYSSVQPEEYSNIVSDVALQDLLAYVSSKHFYLEDLP
QRQPQKVNSIEFVELEQLQPDRLVHAVLRIVDITILTESLYTYRGQKQRKVMLTVEQAQGQHYV
LVLWGLGAAWYPQLQRKKDYIWEFKYLLVQHNCTLETLELHTTPWSSCECLFDDDIRAVTFKTK
FQNSVPTFVKMSDLAAHLKDKYSGVVLIKAQILELVFPVAAAQKITLNAHCSLKSIFSSLPHII
YTGCAKCGLELETDENKIYRQCLSCLPFAKKKTHYRPALMTVADGTHNICIHVGSELIEKILLN
ISPDCLNRIVVPSSEITYGMVAADLLLSLLMDSTEPCVLKIQSLFVLDENSYPLQQDFSLLDFC
PGQCKAWSPSLRPHEEVVDIPKKKY

hide sequence

RefSeq Acc Id:

XP_021587635 ⟸ XM_021731960

- UniProtKB:

I3N8V9 (UniProtKB/TrEMBL), I3N9U8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGGSQVHIFWGAPASPLEMTVSQRTTLMSTADPWKKFQLWYNQHSLHLKDENHEPNNLKDYQV
SEAITGPPDLLSGCCLVNSMSRSVQVKDDFTYFTSETQNIKSQKIYPSGLSDVTNSNVQIHGFK
GTVQHLPEEKKNQKVQCENNKITDEEPKNQSNLCQNFQTNSFQLDHKCAVTLDLVGSTKQTNTD
LEAIETKYKPTEHHEMQNQCLDFFSSNAVDEPRSDRAVRNVSNLKISTDTEFLRIMISSQVAFL
AQREDRALNSINKGTISMETEPKASHGEIRITEDSFIQPNDDFAEGHERGQNEETYSLELFSPI
CPEKKSSHIHINPEKDVEENIESQKLFSSEDKLSPNEICIELCRSGTQCSQLNTFHKSAVKRNW
SSEDKSGNSKALSKVLQVSKKMKLGSNARDSIIAMSQRNVSEFKGIKKISLIKNCDSKSQKYNC
LAMVLTPSQMKEINIKSGPNSGSKVPLATIIVIDQSEIKKKVFLWRTAAFWALTVFLGDIILLT
DVVIHEDQWIGEIILQSTFTSQLLNLGNYSSVQPEEYSNIVSDVALQDLLAYVSSKHFYLEDLP
QRQPQKVNSIEFVELEQLQPDRLVHAVLRIVDITILTESLYTYRGQKQRKVMLTVEQAQGQHYV
LVLWGLGAAWYPQLQRKKDYIWEFKYLLVQHNCTLETLELHTTPWSSCECLFDDDIRAVTFKTK
FQNSVPTFVKMSDLAAHLKDKYSGVVLIKAQILELVFPVAAAQKITLNAHCSLKSIFSSLPHII
YTGCAKCGLELETDENKIYRQCLSCLPFAKKKTHYRPALMTVADGTHNICIHVGSELIEKILLN
ISPDCLNRIVVPSSEITYGMVAADLLLSLLMDSTEPCVLKIQSLFVLDENSYPLQQDFSLLDFC
PGQCKAWSPSLRPHEEVVDIPKKKY

hide sequence

RefSeq Acc Id:	XP_040127874 ⟸ XM_040271940
- UniProtKB:	I3N8V9 (UniProtKB/TrEMBL), I3N9U8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040127875 ⟸ XM_040271941
- UniProtKB:	I3N8V9 (UniProtKB/TrEMBL), I3N9U8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSSTOP00000020805 ⟸ ENSSTOT00000029597

RefSeq Acc Id:

ENSSTOP00000021145 ⟸ ENSSTOT00000027977

Protein Domains

Shieldin complex subunit 2 C-terminal Shieldin complex subunit 2 first OB fold

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000024556	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000027977.2	UniProtKB/TrEMBL
	ENSSTOT00000029597.2	UniProtKB/TrEMBL
InterPro	FAM35A	UniProtKB/TrEMBL
	FAM35A_C	UniProtKB/TrEMBL
	SHLD2_OB1	UniProtKB/TrEMBL
NCBI Gene	Fam35a	ENTREZGENE
PANTHER	PTHR14495	UniProtKB/TrEMBL
	SHIELDIN COMPLEX SUBUNIT 2	UniProtKB/TrEMBL
Pfam	FAM35_C	UniProtKB/TrEMBL
	SHLD2_OB1	UniProtKB/TrEMBL
UniProt	I3N8V9	ENTREZGENE
	I3N9U8	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	I3N8V9	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-01	Shld2	shieldin complex subunit 2	Fam35a	family with sequence similarity 35 member A	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar