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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to leptin stimulus
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Accession:GO:0044320 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.


show annotations for term's descendants           Sort by:
cellular response to leptin stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNA2 cyclin A2 ISO RGD PMID:17303663 RGD:2289137 NCBI chr 4:114,016,917...114,024,816
Ensembl chr 4:125,153,810...125,161,302 		JBrowse link
G FDX1 ferredoxin 1 ISO RGD PMID:10098510 RGD:4145764 NCBI chr11:105,311,613...105,345,414 JBrowse link
G FGB fibrinogen beta chain ISO RGD PMID:17521427 RGD:7175504 NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766 		JBrowse link
G FGF23 fibroblast growth factor 23 ISO RGD PMID:23263654 RGD:10044209 NCBI chr12:4,479,116...4,488,797
Ensembl chr12:4,400,802...4,412,000 		JBrowse link
G GCK glucokinase involved_in ISO PMID:17470517 BHF-UCL PMID:17470517 RGD:8554539 NCBI chr 7:44,857,604...44,903,683
Ensembl chr 7:44,926,848...44,937,751 		JBrowse link
G INHBB inhibin subunit beta B involved_in ISO (MGI:4821933|PMID:19491194) UniProt PMID:19491194 MGI:4821933 NCBI chr2B:7,278,944...7,284,632 JBrowse link
G LEP leptin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519 		JBrowse link
G LOC100983103 surfactant-associated protein 3 ISO RGD PMID:23894445 RGD:12911205 NCBI chr14:17,224,870...17,273,252
Ensembl chr14:35,404,127...35,626,722 		JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 involved_in ISO (MGI:4353981|PMID:19523439) UniProt PMID:19523439 MGI:4353981 NCBI chr 9:70,907,056...70,950,221 JBrowse link
G PID1 phosphotyrosine interaction domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:116,265,529...116,517,557 JBrowse link
G PTEN phosphatase and tensin homolog ISO RGD PMID:24103758 RGD:12802338 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
leptin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOR1 adiponectin receptor 1 ISO RGD PMID:18394428 RGD:2317907 NCBI chr 1:178,542,496...178,560,055
Ensembl chr 1:182,837,589...182,854,782 		JBrowse link
G BBS2 Bardet-Biedl syndrome 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19150989) Ensembl
MGI		 PMID:19150989 GO_REF:0000107 NCBI chr16:36,756,699...36,807,652
Ensembl chr16:55,902,945...55,940,053 		JBrowse link
G BBS4 Bardet-Biedl syndrome 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19150989) Ensembl
MGI		 PMID:19150989 GO_REF:0000107 NCBI chr15:51,601,526...51,656,460
Ensembl chr15:70,362,261...70,416,964 		JBrowse link
G LEP leptin involved_in ISO
IEA		 RGD
Ensembl		 PMID:9070213 PMID:9618284 GO_REF:0000107 RGD:2290293 RGD:2290294 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519 		JBrowse link
G LEPR leptin receptor involved_in ISO
IEA		 RGD
Ensembl		 PMID:9070213 PMID:9618284 GO_REF:0000107 RGD:2290293 RGD:2290294 NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768 		JBrowse link
G MKKS MKKS centrosomal shuttling protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19150989) Ensembl
MGI		 PMID:19150989 GO_REF:0000107 NCBI chr20:10,346,252...10,380,180
Ensembl chr20:10,351,309...10,366,863 		JBrowse link
G MT3 metallothionein 3 involved_in ISO (MGI:5299282|PMID:21726645) UniProt PMID:21726645 MGI:5299282 NCBI chr16:36,875,919...36,877,558
Ensembl chr16:56,007,922...56,028,093 		JBrowse link
G SIRT1 sirtuin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
G UGCG UDP-glucose ceramide glucosyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:83,024,602...83,065,017
Ensembl chr 9:111,184,478...111,222,613 		JBrowse link
negative regulation of appetite by leptin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BBS2 Bardet-Biedl syndrome 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:36,756,699...36,807,652
Ensembl chr16:55,902,945...55,940,053 		JBrowse link
G BBS4 Bardet-Biedl syndrome 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:51,601,526...51,656,460
Ensembl chr15:70,362,261...70,416,964 		JBrowse link
G LEP leptin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519 		JBrowse link
G MKKS MKKS centrosomal shuttling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:10,346,252...10,380,180
Ensembl chr20:10,351,309...10,366,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16442
    response to stimulus 8503
      response to endogenous stimulus 2053
        response to hormone 1241
          response to leptin 29
            cellular response to leptin stimulus 20
              leptin-mediated signaling pathway + 10
Path 2
Term Annotations click to browse term
  biological_process 16442
    cellular process 15499
      cellular response to stimulus 7066
        cellular response to chemical stimulus 2980
          cellular response to organic substance 2227
            cellular response to hormone stimulus 761
              cellular response to leptin stimulus 20
                leptin-mediated signaling pathway + 10
paths to the root