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ONTOLOGY REPORT - ANNOTATIONS


Term:response to leptin
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Accession:GO:0044321 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
Synonyms:exact_synonym: response to leptin stimulus


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response to leptin term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbs2 Bardet-Biedl syndrome 2 ISO MGI:3521669 (MGI:3794515|PMID:18317593) RGD PMID:18317593 MGI:3794515 NCBI chr19:11,385,921...11,421,523
Ensembl chr19:11,386,024...11,421,498
JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 ISO MGI:3045473 (MGI:3794515|PMID:18317593) RGD PMID:18317593 MGI:3794515 NCBI chr 8:64,115,005...64,154,432
Ensembl chr 8:64,121,392...64,154,396
JBrowse link
G Ccnd1 cyclin D1 ISO (PMID:17344214) RGD PMID:17344214 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Edn1 endothelin 1 IEP RGD PMID:16144973 RGD:8662327 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Fdx1 ferredoxin 1 IEP RGD PMID:11604238 RGD:4145667 NCBI chr 8:56,373,729...56,393,199
Ensembl chr 8:56,373,723...56,393,233
JBrowse link
G Ghrh growth hormone releasing hormone IEP RGD PMID:18806317 RGD:5687187 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IEP RGD PMID:23073237 RGD:13792788 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Lepr leptin receptor IEP
ISO
(MGI:2652302|PMID:12594516) RGD PMID:12594516, PMID:18515494 MGI:2652302, RGD:5129110 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lrp2 LDL receptor related protein 2 ISO
IEA
IMP
(PMID:17324488)
(MGI:3814816|PMID:17324488)
GO_REF:0000107
RGD
Ensembl
PMID:17324488, PMID:17324488 GO_REF:0000107 MGI:3814816, RGD:13210549 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Mkks McKusick-Kaufman syndrome ISO MGI:3526444 (MGI:3794515|PMID:18317593) RGD PMID:18317593 MGI:3794515 NCBI chr 3:129,866,542...129,885,213
Ensembl chr 3:129,866,545...129,884,810
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 IEA
IBA
ISO
ISS
GO_REF:0000107
PMID:21873635
(MGI:5313784|PMID:22166979)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22166979, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5313784, RGD:13792537 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IEP RGD PMID:16375900 RGD:9999182 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:4821191|PMID:20620997) RGD PMID:20620997 MGI:4821191 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Star steroidogenic acute regulatory protein IEP RGD PMID:11604238 RGD:4145667 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
ISS
(PMID:17344214)
(MGI:2652302|PMID:12594516), (MGI:5700303|PMID:16825198)
GO_REF:0000024
RGD
UniProt
PMID:12594516 PMID:16825198 PMID:17344214 GO_REF:0000024 MGI:2652302 MGI:5700303 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
cellular response to leptin stimulus term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccna2 cyclin A2 IEP RGD PMID:17303663 RGD:2289137 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Fdx1 ferredoxin 1 IEP RGD PMID:10098510 RGD:4145764 NCBI chr 8:56,373,729...56,393,199
Ensembl chr 8:56,373,723...56,393,233
JBrowse link
G Fgb fibrinogen beta chain IEP RGD PMID:17521427 RGD:7175504 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgf23 fibroblast growth factor 23 IEP RGD PMID:23263654 RGD:10044209 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082
JBrowse link
G Gck glucokinase IDA PMID:17470517 BHF-UCL PMID:17470517 RGD:8554539 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Inhbb inhibin subunit beta B IEA
ISO
GO_REF:0000107
(PMID:19491194)
Ensembl
RGD
PMID:19491194 GO_REF:0000107 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Lep leptin ISO (PMID:17344214) RGD PMID:17344214 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nkx2-1 NK2 homeobox 1 IEP RGD PMID:23894445 RGD:12911205 NCBI chr 6:77,418,096...77,423,383
Ensembl chr 6:77,418,096...77,421,286
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 ISS
ISO
GO_REF:0000024
(MGI:4353981|PMID:19523439)
UniProt
RGD
PMID:19523439 GO_REF:0000024 MGI:4353981 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 ISO (MGI:5308004|PMID:19894142) RGD PMID:19894142 MGI:5308004 NCBI chr 9:91,667,748...91,683,468
Ensembl chr 9:91,665,986...91,882,927
JBrowse link
G Pten phosphatase and tensin homolog IMP RGD PMID:24103758 RGD:12802338 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
ISS
(PMID:17344214)
GO_REF:0000024
RGD
UniProt
PMID:17344214 GO_REF:0000024 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
leptin-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 IMP RGD PMID:18394428 RGD:2317907 NCBI chr13:51,240,470...51,260,233
Ensembl chr13:51,240,911...51,260,228
JBrowse link
G Bbs2 Bardet-Biedl syndrome 2 ISO MGI:3521669 (MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:3836843 NCBI chr19:11,385,921...11,421,523
Ensembl chr19:11,386,024...11,421,498
JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 ISO MGI:3045473 (MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:3836843 NCBI chr 8:64,115,005...64,154,432
Ensembl chr 8:64,121,392...64,154,396
JBrowse link
G Ebi3 Epstein-Barr virus induced 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:11,110,874...11,114,843
Ensembl chr 9:11,110,874...11,114,843
JBrowse link
G Lep leptin IDA
ISO
(MGI:5700303|PMID:16825198)
PMID:11677594
RGD PMID:16825198, PMID:9070213, PMID:11677594, PMID:9618284 MGI:5700303, RGD:2290293, RGD:10448951, RGD:2290294 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor IDA
IBA
ISO
IEA
PMID:21873635
(MGI:2652302|PMID:12594516)
(PMID:27037668)
GO_REF:0000107
RGD
Ensembl
PMID:12594516 PMID:27037668, PMID:9070213, PMID:21873635, PMID:9618284 GO_REF:0000107 MGI:2652302, RGD:2290293, RGD:13792537, RGD:2290294 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lepr_v1 leptin receptor, variant 1 IDA RGD PMID:9070213, PMID:9618284 RGD:2290293, RGD:2290294
G Lepr_v2 leptin receptor, variant 2 IDA RGD PMID:9070213, PMID:9618284 RGD:2290293, RGD:2290294
G Mkks McKusick-Kaufman syndrome ISO MGI:3526444 (MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:3836843 NCBI chr 3:129,866,542...129,885,213
Ensembl chr 3:129,866,545...129,884,810
JBrowse link
G Mt3 metallothionein 3 ISS
ISO
GO_REF:0000024
(MGI:5299282|PMID:21726645)
UniProt
RGD
PMID:21726645 GO_REF:0000024 MGI:5299282 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:4821191|PMID:20620997) RGD PMID:20620997 MGI:4821191 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
IBA
ISS
(PMID:17344214)
PMID:21873635
(MGI:2652302|PMID:12594516), (MGI:5700303|PMID:16825198)
GO_REF:0000024
RGD
UniProt
PMID:12594516 PMID:16825198 PMID:17344214, PMID:21873635 GO_REF:0000024 MGI:2652302 MGI:5700303, RGD:13792537 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase ISS
ISO
GO_REF:0000024
(MGI:5634638|PMID:23554574)
UniProt
RGD
PMID:23554574 GO_REF:0000024 MGI:5634638 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
negative regulation of appetite by leptin-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbs2 Bardet-Biedl syndrome 2 ISO (MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:3836843 NCBI chr19:11,385,921...11,421,523
Ensembl chr19:11,386,024...11,421,498
JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 ISO (MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:3836843 NCBI chr 8:64,115,005...64,154,432
Ensembl chr 8:64,121,392...64,154,396
JBrowse link
G Lep leptin IDA
IBA
PMID:11677594
PMID:21873635
UniProt
GO_Central
PMID:11677594, PMID:21873635 RGD:10448951, RGD:13792537 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mkks McKusick-Kaufman syndrome ISO (MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:3836843 NCBI chr 3:129,866,542...129,885,213
Ensembl chr 3:129,866,545...129,884,810
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20044
    response to stimulus 10558
      response to endogenous stimulus 2034
        response to hormone 1216
          response to leptin 31
            cellular response to leptin stimulus + 23
Path 2
Term Annotations click to browse term
  biological_process 20044
    response to stimulus 10558
      response to chemical 6329
        response to organic substance 3873
          response to hormone 1216
            response to leptin 31
              cellular response to leptin stimulus + 23
paths to the root