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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:TRIF-dependent toll-like receptor signaling pathway
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Accession:GO:0035666 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
Synonyms:exact_synonym: TRIF-dependent TLR signaling pathway;   TRIF-dependent toll-like receptor signalling pathway;   Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway

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TRIF-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule involved_in ISO (PMID:36232715) UniProt PMID:36232715 NCBI chrNW_004955434:9,487,309...9,508,366
Ensembl chrNW_004955434:9,487,315...9,505,904 		JBrowse link
G Cd300lf CD300 molecule like family member f involved_in ISO (PMID:22043923) UniProt PMID:22043923 NCBI chrNW_004955553:1,596,406...1,610,479
Ensembl chrNW_004955553:1,488,501...1,610,555 		JBrowse link
G Irf3 interferon regulatory factor 3 involved_in ISO (PMID:25636800) UniProt PMID:25636800 NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624 		JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 involved_in ISO (PMID:25636800)
(MGI:3718934|PMID:17658277)		 CACAO
ParkinsonsUK-UCL		 PMID:17658277 PMID:25636800 MGI:3718934 NCBI chrNW_004955495:4,197,083...4,204,999
Ensembl chrNW_004955495:4,202,372...4,204,513 		JBrowse link
G Tlr4 toll like receptor 4 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12352
    immune system process 1980
      activation of immune response 435
        activation of innate immune response 250
          innate immune response-activating signaling pathway 236
            pattern recognition receptor signaling pathway 234
              toll-like receptor signaling pathway 62
                MyD88-independent toll-like receptor signaling pathway 13
                  TRIF-dependent toll-like receptor signaling pathway 6
                    TRIF-dependent toll-like receptor 4 signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 12352
    response to stimulus 6684
      response to biotic stimulus 1289
        response to external biotic stimulus 1246
          response to other organism 1243
            defense response to other organism 830
              defense response to symbiont 736
                innate immune response 609
                  regulation of innate immune response 374
                    positive regulation of innate immune response 310
                      activation of innate immune response 250
                        innate immune response-activating signaling pathway 236
                          pattern recognition receptor signaling pathway 234
                            toll-like receptor signaling pathway 62
                              MyD88-independent toll-like receptor signaling pathway 13
                                TRIF-dependent toll-like receptor signaling pathway 6
                                  TRIF-dependent toll-like receptor 4 signaling pathway 0
paths to the root