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ONTOLOGY REPORT - ANNOTATIONS

Term:beta-catenin destruction complex
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Accession:GO:0030877 term browser browse the term
Definition:A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.
Comment:Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Synonyms:exact_synonym: APC-Axin-1-beta-catenin complex;   Axin-APC-beta-catenin-GSK3B complex;   BDC;   beta-catenin degradation complex
 narrow_synonym: 23S APC complex
 alt_id: GO:0034742;   GO:0034747


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beta-catenin destruction complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:108,070,697...108,208,273
Ensembl chr 5:113,904,352...114,009,709 		JBrowse link
G AXIN1 axin 1 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr16:278,239...337,891 JBrowse link
G AXIN2 axin 2 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr17:59,476,336...59,509,358
Ensembl chr17:64,688,416...64,720,086 		JBrowse link
G CACYBP calcyclin binding protein part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:150,511,021...150,522,369
Ensembl chr 1:154,210,001...154,220,583 		JBrowse link
G CLSTN1 calsyntenin 1 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:8,495,571...8,591,613
Ensembl chr 1:9,724,743...9,774,760
Ensembl chr 1:9,724,743...9,774,760 		JBrowse link
G CSNK1A1 casein kinase 1 alpha 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr 5:144,919,775...144,977,105
Ensembl chr 5:150,929,420...150,985,912 		JBrowse link
G CTNNB1 catenin beta 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030 		JBrowse link
G CTNNBIP1 catenin beta interacting protein 1 part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118
G DACT1 dishevelled binding antagonist of beta catenin 1 part_of
located_in		 IEA
ISO		 (PMID:22470507) Ensembl
UniProt		 PMID:22470507 GO_REF:0000107 NCBI chr14:39,231,910...39,242,353
Ensembl chr14:57,499,906...57,510,019 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G SIAH1 siah E3 ubiquitin protein ligase 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr16:28,627,021...28,651,343
Ensembl chr16:47,517,594...47,522,936 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17179
    protein-containing complex 5908
      catalytic complex 1706
        beta-catenin destruction complex 11
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