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ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
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Accession:GO:0140627 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms.
Synonyms:exact_synonym: DesCEND


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ubiquitin-dependent protein catabolic process via the C-end degron rule pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cul2 cullin 2 involved_in ISO (PMID:29779948) RGD PMID:29779948 NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968 		JBrowse link
G Cul4a cullin 4A involved_in ISO (PMID:34065512) RGD PMID:34065512 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330 		JBrowse link
G Dcaf12 DDB1 and CUL4 associated factor 12 involved_in ISO (PMID:29779948), (PMID:31267705), (PMID:34065512) RGD PMID:29779948 PMID:31267705 PMID:34065512 NCBI chr 5:56,460,418...56,482,171
Ensembl chr 5:56,461,006...56,482,456 		JBrowse link
G Fem1a fem-1 homolog A involved_in ISS
ISO		 GO_REF:0000024
(PMID:29779948), (PMID:33398168), (PMID:33398170)		 UniProt
RGD		 PMID:29779948 PMID:33398168 PMID:33398170 GO_REF:0000024 NCBI chr 9:1,091,695...1,093,901
Ensembl chr 9:1,090,527...1,100,628 		JBrowse link
G Fem1b fem-1 homolog B involved_in ISS
ISO		 GO_REF:0000024
(PMID:29779948), (PMID:33398168), (PMID:33398170)
(PMID:34562363)		 UniProt
RGD		 PMID:29779948 PMID:33398168 PMID:33398170 PMID:34562363 GO_REF:0000024 NCBI chr 8:63,265,301...63,278,577
Ensembl chr 8:63,265,301...63,278,577 		JBrowse link
G Fem1c fem-1 homolog C involved_in ISO (PMID:29775578), (PMID:29779948), (PMID:33398170) RGD PMID:29775578 PMID:29779948 PMID:33398170 NCBI chr18:39,232,900...39,258,692
Ensembl chr18:39,232,900...39,258,692 		JBrowse link
G Klhdc1 kelch domain containing 1 involved_in ISO (PMID:32200094) RGD PMID:32200094 NCBI chr 6:87,670,182...87,765,431
Ensembl chr 6:87,712,772...87,765,424 		JBrowse link
G Klhdc10 kelch domain containing 10 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:29779948), (PMID:33909987)		 UniProt
Ensembl
RGD		 PMID:29779948 PMID:33909987 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:59,021,300...59,079,118
Ensembl chr 4:59,021,310...59,074,941 		JBrowse link
G Klhdc2 kelch domain containing 2 involved_in ISO
ISS		 (PMID:29775578), (PMID:29779948), (PMID:30526872)
GO_REF:0000024		 RGD
UniProt		 PMID:29775578 PMID:29779948 PMID:30526872 GO_REF:0000024 NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187 		JBrowse link
G Klhdc3 kelch domain containing 3 involved_in ISO
IEA		 (PMID:29779948)
GO_REF:0000107		 RGD
Ensembl		 PMID:29779948 GO_REF:0000107 NCBI chr 9:14,302,345...14,308,736
Ensembl chr 9:14,302,354...14,308,736 		JBrowse link
G Rbx1 ring-box 1 involved_in ISO (PMID:29779948), (PMID:34065512) RGD PMID:29779948 PMID:34065512 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Trpc4ap transient receptor potential cation channel, subfamily C, member 4 associated protein involved_in ISO (PMID:29779948) RGD PMID:29779948 NCBI chr 3:144,122,003...144,192,986
Ensembl chr 3:144,122,003...144,192,986 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        catabolic process 2871
          macromolecule catabolic process 1631
            protein catabolic process 1148
              proteasomal protein catabolic process 612
                proteasome-mediated ubiquitin-dependent protein catabolic process 477
                  ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 12
Path 2
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        primary metabolic process 10582
          protein metabolic process 5297
            protein catabolic process 1148
              proteolysis involved in protein catabolic process 870
                modification-dependent protein catabolic process 693
                  ubiquitin-dependent protein catabolic process 678
                    proteasome-mediated ubiquitin-dependent protein catabolic process 477
                      ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 12
paths to the root