Fem1a (fem-1 homolog A) - Rat Genome Database

Name: Fem1a
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Fem1a (fem-1 homolog A) Rattus norvegicus

Analyze

Symbol:

Fem1a

Name:

fem-1 homolog A

RGD ID:

1561112

Description:

Predicted to enable EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in negative regulation of inflammatory response; positive regulation of inflammatory response; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in mitochondrion. Orthologous to human FEM1A (fem-1 homolog A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

fem-1 homolog a (C. elegans); FEM1-alpha; feminization 1 homolog a; feminization 1 homolog a (C. elegans); feminization of XX and XO animals 1A; LOC316131; MGC114562; protein fem-1 homolog A; similar to sex-determination protein homolog Fem1a

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FEM1A (fem-1 homolog A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Fem1a (fem 1 homolog a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fem1a (fem-1 homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100973655 (protein fem-1 homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FEM1A (fem-1 homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fem1a (fem-1 homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FEM1A (fem-1 homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103233730 (protein fem-1 homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fem1a (fem-1 homolog A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PSMD10 (proteasome 26S subunit, non-ATPase 10)	HGNC	PhylomeDB
Alliance orthologs ³
Homo sapiens (human):	FEM1A (fem-1 homolog A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fem1a (fem 1 homolog a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fem1al (fem-1 homolog A like)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	fem1a (fem-1 homolog a (C. elegans))	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG6966	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fem-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	1,178,857 - 1,181,063 (+)	NCBI		GRCr8
mRatBN7.2	9	1,091,695 - 1,093,901 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,090,527 - 1,100,628 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	1,537,395 - 1,539,601 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	6,885,362 - 6,887,568 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	5,842,433 - 5,844,639 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	10,798,934 - 10,801,140 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	10,798,946 - 10,801,140 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	9,790,602 - 9,792,808 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,416,121 - 7,418,327 (-)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (EXP)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

cadmium dichloride (EXP)

clofibrate (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

epoxiconazole (ISO)

folic acid (ISO)

furan (EXP)

indometacin (ISO)

methotrexate (ISO)

paracetamol (EXP,ISO)

potassium chromate (ISO)

rimonabant (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of inflammatory response (IBA,ISO)

negative regulation of non-canonical NF-kappaB signal transduction (IEA)

positive regulation of inflammatory response (ISO,ISS)

protein ubiquitination (IEA)

ubiquitin-dependent protein catabolic process (IBA)

ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (ISO,ISS)

Cellular Component

Cul2-RING ubiquitin ligase complex (ISO,ISS)

cytosol (IEA)

mitochondrion (ISO,ISS)

nucleus (IEA)

ubiquitin ligase complex (IBA)

Molecular Function

EP4 subtype prostaglandin E2 receptor binding (ISO)

protein binding (ISO)

ubiquitin-like ligase-substrate adaptor activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:16424369	PMID:18270204

Genomics

Comparative Map Data

Fem1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	1,178,857 - 1,181,063 (+)	NCBI		GRCr8
mRatBN7.2	9	1,091,695 - 1,093,901 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,090,527 - 1,100,628 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	1,537,395 - 1,539,601 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	6,885,362 - 6,887,568 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	5,842,433 - 5,844,639 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	10,798,934 - 10,801,140 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	10,798,946 - 10,801,140 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	9,790,602 - 9,792,808 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,416,121 - 7,418,327 (-)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

FEM1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	4,791,734 - 4,801,273 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	4,791,734 - 4,801,273 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	4,791,746 - 4,801,285 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	4,742,728 - 4,746,571 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	4,742,769 - 4,746,567	NCBI
Celera	19	4,729,623 - 4,733,477 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	4,553,385 - 4,557,238 (+)	NCBI		HuRef
CHM1_1	19	4,791,252 - 4,795,104 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	4,777,196 - 4,786,749 (+)	NCBI		T2T-CHM13v2.0

Fem1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	56,563,793 - 56,570,608 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	56,563,810 - 56,570,610 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	56,256,793 - 56,263,608 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	56,256,810 - 56,263,610 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	56,396,216 - 56,403,031 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	55,890,531 - 55,894,784 (+)	NCBI		MGSCv36	mm8
Celera	17	60,359,868 - 60,366,683 (+)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.24	NCBI

Fem1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	4,215,284 - 4,217,230 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	4,214,250 - 4,217,313 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100973655
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	18,217,371 - 18,247,982 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	9,321,794 - 9,350,556 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	468,156 - 495,596 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	4,763,448 - 4,767,394 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	4,763,674 - 4,765,683 (+)	Ensembl	panpan1.1		panPan2

FEM1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	54,971,654 - 54,975,236 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	54,973,083 - 54,975,104 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	54,696,306 - 54,699,889 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	55,626,045 - 55,629,628 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	55,627,467 - 55,629,489 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	54,687,398 - 54,690,980 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	55,167,987 - 55,171,571 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	55,365,967 - 55,369,558 (-)	NCBI		UU_Cfam_GSD_1.0

Fem1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	215,023,045 - 215,026,253 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	2,808,679 - 2,810,616 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	2,808,561 - 2,811,738 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FEM1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	74,042,989 - 74,044,983 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	74,041,391 - 74,045,123 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LOC103233730
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	4,503,012 - 4,506,873 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	4,503,146 - 4,505,155 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023668252	660 - 4,563 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fem1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	4,990,299 - 4,992,287 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	4,989,025 - 4,992,730 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fem1a
3 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	47
Interacting mature miRNAs:	53
Transcripts:	ENSRNOT00000072771
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	14209783	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC097490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000072771 ⟹ ENSRNOP00000067295

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	10,798,946 - 10,801,140 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099590 ⟹ ENSRNOP00000091315

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	1,090,527 - 1,100,628 (+)	Ensembl

RefSeq Acc Id:

NM_001025706 ⟹ NP_001020877

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	1,178,857 - 1,181,063 (+)	NCBI
mRatBN7.2	9	1,091,695 - 1,093,901 (+)	NCBI
Rnor_6.0	9	10,798,934 - 10,801,140 (-)	NCBI
Rnor_5.0	9	9,790,602 - 9,792,808 (-)	NCBI
Celera	9	7,416,121 - 7,418,327 (-)	RGD

Sequence:

show sequence

GCTGAGATGACAGCCGGGGAGAAGGTGAAGGTTGTCTCTGGGGATCCGCGACCCGGCTAGATCC
GTCAGCAAGACTTCCAGCATGGATCTACACACAGCGGTGTACAATGCGGCGCACGACGGCAAGC
TGCTGCTGCTTCAGAAGCTGCTGGCCGGCCGCGGGCGTGAGGAGATAGAGGAGCTGCTGGGTGA
GGTGGCCGGCGGTGGCACACCACTGCTAATCGCGGCGCGCCGTGGACACCTGGACGTGGTGGAG
TACCTGGTGGACAACTGCGGCGCCAGTGTGGAGGCGAGCGGCTCCGTACACTTCGATGGCGAGA
CTATTGAGGGCGCGCCGCCGCTATGGGCAGCGTCAGCAGCGGGTCACTTAGCTGTGGTGCGTAG
CCTTCTGCGCCGAGGCGCCTCGGTCAACCGCACTACGCGCACCAACTCTACGCCGCTACGCGCC
GCGTGCTTTGACGGCCACCTGGACGTGGTGCGCTACCTGGTGGGCGAGCACAAGGCGGACCTAG
AGGTAGCCAACCGCCACGGCCACACGTGCCTTATGATATCATGCTACAAGGGCCACCGCGAGAT
TGCGCGCTACCTCCTGGAACGGGGCGCGCAGGTGAATCGTCGCAGCGCCAAGGGCAACACCGCC
CTTCACGACTGTGCGGAATCTGGCAGCCTGGAGATTCTGCAGCTGCTGCTGGGCTGTCACGCGC
GTATGGAACGCGACGGCTATGGCATGACCCCGCTACTGGCTGCCAGCGTCACCGGGCACACCAA
CATCGTGGAGTACCTCATCCAGGAACAGCCCGGCCACGGGCAGCTCTCAGGGACAGAGCTTCCC
GGAGAAGGCTCCTCCCAGATGGCAGGAAACCACTGTTCCACCCCAGAGGAAGCAGAACCGTATG
AGAGCTGCTGCCCTACCAGCCGGGAAGCGGCTGTGGAAGCTTTGGAGCTGCTAGGTGCTACCTA
TGTCGATAAGAAAAGGGATCTGCTTGGAGCCCTGAAGCATTGGAGACGGGCAATGGAACTCCGC
CACCAGGGTGGGGACTACCTTCCTAAGCCTGAACCCCAGCAACTGGTTCTAGCCTATGACTATT
CCAGGGAGGTGAGCACGCCCCAAGAGTTGGAAGCCCTCATCACAGATCCTGATGAGATGCGGAT
GCAGGCACTGCTGATACGGGAGAGGATCCTGGGCCCCTCGCATCCTGACACTTCATATTACATA
AGATACCGGGGTGCTGTCTATGCAGACTCTGGAAATTTCGAGCGCTGTATCCGTCTGTGGAAGT
ATGCCTTGGACATGCAACAGAACAACCTGGAGCCCCTGAGCCCCATGACCGCCAGCAGCTTCCT
GTCGTTTGCAGAGCTCTTCTCCTACGTGCTGCAGGACCGCTCAGCCAAGGGCAACCTAGGCATG
CAGCTTGGCTTTGCTGACCTCATGGGTGTGCTCAGCAAAGGGGTTCGGGAAGTGGAGCGGGCTC
TACAGCTGCCCAAGGAACCGGGTGACTCTGCACAGTTCACCAAAGCCATTGCCATCATCCTCCA
CCTTCTGTATCTGCTGGAGAAGGTGGAGTGCACCCCCAGCCAGGAACACCTCAAGCACCAGACA
GTCTACCGCCTGCTCAAGTGTGCCCCTCGAGGTAAGAACGGCTTCACCCCACTGCACATGGCAG
TGGATAAGGAGACCACCAACGTGGGCCGGTACCGTGTGGGCATCTTCCCGTCGTTGCAGGTGGT
GAAGGTACTGTTGGACTGCGGAGCAGACCCTGACAGCAGGGACTTCGACAACAACACACCACTG
CATGTCGCTGCCCAGAACAATTGCCCTGCCATCATGGATGCCCTCATCGAAGCTGGAGCCCACA
TGGATGCCACCAATGCCTTCAAGAAGACTGCCTACGAGCTGCTGGACTCGAAGCTGTTAGCCAA
GAGCACCATGCAGCCCTTCAATTATGTGACACTCCAGTGCCTAGCTGCTCGTGCCCTGGACAGG
AACAAGGTCCCTTATAAGGGCTTTATCCCAGAGGAGCTGGAGGCCTTCATCCAGTTACACTGAG
CCTGGCCCAGCCACTGGTGCCCACTTAGGCCTTACTTCTCCAAGCAGAAGCATCCACTCCCCTT
GGCCTGTTGGAGGGAGCCCAGCTGTTGATTCTAGAAGCCTCCAGGGTCACATGGTAGGAAGATG
GTCTTTCTTTGTGGAAATGAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020877	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97490	(Get FASTA)	NCBI Sequence Viewer
	EDL83649	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000091315
	ENSRNOP00000091315.1
	ENSRNOP00055021222
	ENSRNOP00060027311
	ENSRNOP00065017393
GenBank Protein	Q4V890	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001020877 ⟸ NM_001025706

- UniProtKB:

Q4V890 (UniProtKB/Swiss-Prot), A6KQZ1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDLHTAVYNAAHDGKLLLLQKLLAGRGREEIEELLGEVAGGGTPLLIAARRGHLDVVEYLVDNC
GASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLRRGASVNRTTRTNSTPLRAACFDGH
LDVVRYLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAE
SGSLEILQLLLGCHARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGHGQLSGTELPGEGSSQ
MAGNHCSTPEEAEPYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGDY
LPKPEPQQLVLAYDYSREVSTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAV
YADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRSAKGNLGMQLGFAD
LMGVLSKGVREVERALQLPKEPGDSAQFTKAIAIILHLLYLLEKVECTPSQEHLKHQTVYRLLK
CAPRGKNGFTPLHMAVDKETTNVGRYRVGIFPSLQVVKVLLDCGADPDSRDFDNNTPLHVAAQN
NCPAIMDALIEAGAHMDATNAFKKTAYELLDSKLLAKSTMQPFNYVTLQCLAARALDRNKVPYK
GFIPEELEAFIQLH

hide sequence

RefSeq Acc Id:

ENSRNOP00000067295 ⟸ ENSRNOT00000072771

RefSeq Acc Id:

ENSRNOP00000091315 ⟸ ENSRNOT00000099590

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V890-F1-model_v2	AlphaFold	Q4V890	1-654	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696464

Promoter ID:

EPDNEW_R6989

Type:

multiple initiation site

Name:

Fem1a_1

Description:

fem-1 homolog A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	10,801,157 - 10,801,217	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561112	AgrOrtholog
BioCyc Gene	G2FUF-28539	BioCyc
Ensembl Genes	ENSRNOG00000050646	Ensembl
	ENSRNOG00000066151	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055015251	UniProtKB/Swiss-Prot
	ENSRNOG00060019318	UniProtKB/Swiss-Prot
	ENSRNOG00065013637	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000099590	ENTREZGENE
	ENSRNOT00000099590.1	UniProtKB/Swiss-Prot
	ENSRNOT00055026060	UniProtKB/Swiss-Prot
	ENSRNOT00060033378	UniProtKB/Swiss-Prot
	ENSRNOT00065022434	UniProtKB/Swiss-Prot
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot
	1.25.40.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tetratricopeptide repeat domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7460827	IMAGE-MGC_LOAD
InterPro	Ankyrin_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:316131	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:114562	IMAGE-MGC_LOAD
NCBI Gene	316131	ENTREZGENE
PANTHER	ANKYRIN REPEAT CONTAINING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANKYRIN REPEAT DOMAIN 16	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ank_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Fem1a	PhenoGen
PRINTS	ANKYRIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000050646	RatGTEx
	ENSRNOG00000066151	RatGTEx
	ENSRNOG00055015251	RatGTEx
	ENSRNOG00060019318	RatGTEx
	ENSRNOG00065013637	RatGTEx
SMART	ANK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Ankyrin repeat	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	SSF48452	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6KQZ1	ENTREZGENE, UniProtKB/TrEMBL
	FEM1A_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-17	Fem1a	fem-1 homolog A	Fem1a	feminization of XX and XO animals 1A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2022-05-03	Fem1a	feminization of XX and XO animals 1A	Fem1a	feminization of XX and XO animals 1 A	Name changed	629549	APPROVED
2022-05-03	Fem1a	feminization of XX and XO animals 1 A	Fem1a	fem-1 homolog A	Name changed	629549	APPROVED
2016-03-29	Fem1a	fem-1 homolog A	Fem1a	fem-1 homolog a (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-02-04	Fem1a	fem-1 homolog a (C. elegans)	Fem1a	feminization 1 homolog a (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Fem1a	feminization 1 homolog a (C. elegans)	LOC316131	similar to sex-determination protein homolog Fem1a	Symbol and Name updated	1299863	APPROVED
2006-02-09	LOC316131	similar to sex-determination protein homolog Fem1a			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar