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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:granzyme-mediated programmed cell death signaling pathway
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Accession:GO:0140507 term browser browse the term
Definition:The series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells.
Synonyms:broad_synonym: granzyme-mediated cell death signaling pathway


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granzyme-mediated programmed cell death signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:9396766) RGD PMID:9396766 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:31953257), (PMID:32188940) RGD PMID:31953257 PMID:32188940 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Gzma granzyme A involved_in ISO (PMID:32299851), (PMID:34022140) RGD PMID:32299851 PMID:34022140 NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
G Gzmb granzyme B involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:20038786), (PMID:31953257), (PMID:32188940), (PMID:9852092)
(PMID:35705808)
MGI:1857156 (PMID:15454490), (PMID:16618603)		 UniProt
RGD		 PMID:9852092 PMID:15454490 PMID:16618603 PMID:20038786 PMID:31953257 More... GO_REF:0000024 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in ISO
IEA		 (PMID:23632890)
GO_REF:0000107		 RGD
Ensembl		 PMID:23632890 GO_REF:0000107 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Nkg7 natural killer cell granule protein 7 involved_in ISO (MGI:6810811|PMID:33911019) RGD PMID:33911019 MGI:6810811 NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983 		JBrowse link
G Prf1 perforin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:35705808)		 Ensembl
RGD		 PMID:35705808 GO_REF:0000107 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Srgn serglycin involved_in ISO
ISS		 (PMID:11911826)
GO_REF:0000024		 RGD
UniProt		 PMID:11911826 GO_REF:0000024 NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406 		JBrowse link
granzyme-mediated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube4b ubiquitination factor E4B involved_in ISO (PMID:11802788) RGD PMID:11802788 NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    cellular process 18195
      signal transduction 7005
        granzyme-mediated programmed cell death signaling pathway 9
          granzyme-mediated apoptotic signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 19692
    biological regulation 13305
      regulation of biological process 12902
        signaling 7581
          signal transduction 7005
            granzyme-mediated programmed cell death signaling pathway 9
              granzyme-mediated apoptotic signaling pathway 1
paths to the root