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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellular vesicle biogenesis
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Accession:GO:0140112 term browser browse the term
Definition:The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.
Synonyms:exact_synonym: extracellular vesicle assembly

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extracellular vesicle biogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc1 arrestin domain containing 1 involved_in ISO (PMID:27462458) UniProt PMID:27462458 NCBI chrNW_004624760:464,914...475,070
Ensembl chrNW_004624760:468,069...475,070 		JBrowse link
G Arrdc4 arrestin domain containing 4 involved_in ISO (MGI:5804712|PMID:27462458) UniProt PMID:27462458 MGI:5804712 NCBI chrNW_004624768:6,248,082...6,260,600 JBrowse link
exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624744:24,287,278...24,308,171
Ensembl chrNW_004624744:24,287,443...24,308,024 		JBrowse link
G Rab11a RAB11A, member RAS oncogene family involved_in ISO (PMID:15634213) UniProt PMID:15634213 NCBI chrNW_004624781:6,699,926...6,718,020
Ensembl chrNW_004624781:6,699,926...6,718,545 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:23092844) UniProt PMID:23092844 NCBI chrNW_004624731:6,315,064...6,355,431
Ensembl chrNW_004624731:6,319,092...6,355,534 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:18617898) MGI PMID:18617898 NCBI chrNW_004624732:25,913,034...25,958,537
Ensembl chrNW_004624732:25,913,736...25,958,582 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (MGI:5770036|PMID:25392495) ParkinsonsUK-UCL PMID:25392495 MGI:5770036 NCBI chrNW_004624766:9,932,190...9,977,725
Ensembl chrNW_004624766:9,934,228...9,977,697 		JBrowse link
extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 molecule involved_in ISO (PMID:21835908) UniProt PMID:21835908 NCBI chrNW_004624807:3,936,043...3,958,274
Ensembl chrNW_004624807:3,936,028...3,957,249 		JBrowse link
extracellular exosome biogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:25392495) ParkinsonsUK-UCL PMID:25392495 NCBI chrNW_004624764:2,614,541...2,631,972
Ensembl chrNW_004624764:2,614,827...2,631,793 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (MGI:5914142|PMID:25686249) UniProt PMID:25686249 MGI:5914142 NCBI chrNW_004624788:11,772,268...11,849,040
Ensembl chrNW_004624788:11,772,396...11,845,765 		JBrowse link
negative regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp9a ATPase phospholipid transporting 9A (putative) involved_in ISO (PMID:30947313) UniProt PMID:30947313 NCBI chrNW_004624790:4,187,643...4,328,933
Ensembl chrNW_004624790:4,188,052...4,328,920 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:26911690) ParkinsonsUK-UCL PMID:26911690 NCBI chrNW_004624855:430,148...1,992,121
Ensembl chrNW_004624855:430,260...1,989,747 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:26911690) ParkinsonsUK-UCL PMID:26911690 NCBI chrNW_004625042:56,509...112,519
Ensembl chrNW_004625042:56,517...112,612 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO (PMID:24105262) UniProt PMID:24105262 NCBI chrNW_004624792:9,098,291...9,128,931 JBrowse link
positive regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:24603074)
(MGI:5770036|PMID:25392495)
(PMID:25392495)		 ParkinsonsUK-UCL PMID:24603074 PMID:25392495 MGI:5770036 NCBI chrNW_004624764:2,614,541...2,631,972
Ensembl chrNW_004624764:2,614,827...2,631,793 		JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624832:45,293...48,314 JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624801:10,620,717...10,634,670
Ensembl chrNW_004624801:10,620,753...10,634,341 		JBrowse link
G Myo5b myosin VB ISO RGD PMID:18984164 RGD:11533643 NCBI chrNW_004624778:13,352,285...13,740,621
Ensembl chrNW_004624778:13,347,705...13,740,767 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624788:11,772,268...11,849,040
Ensembl chrNW_004624788:11,772,396...11,845,765 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004625042:56,509...112,519
Ensembl chrNW_004625042:56,517...112,612 		JBrowse link
G Sdc1 syndecan 1 involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624738:2,920,154...2,938,035 JBrowse link
G Sdc4 syndecan 4 involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624790:9,146,371...9,166,729
Ensembl chrNW_004624790:9,145,745...9,169,526 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624744:33,524,045...33,558,963
Ensembl chrNW_004624744:33,524,416...33,557,025 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in ISO PMID:24743145 BHF-UCL PMID:24743145 RGD:10054083 NCBI chrNW_004624746:17,857,779...17,948,469
Ensembl chrNW_004624746:17,920,835...17,948,468 		JBrowse link
G Snf8 SNF8 subunit of ESCRT-II involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624795:5,318,803...5,328,542
Ensembl chrNW_004624795:5,318,802...5,328,768 		JBrowse link
G Stam signal transducing adaptor molecule involved_in ISO (PMID:24105262) UniProt PMID:24105262 NCBI chrNW_004624796:10,195,897...10,269,311
Ensembl chrNW_004624796:10,201,518...10,269,311 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:22660413), (PMID:24105262) UniProt PMID:22660413 PMID:24105262 NCBI chrNW_004624766:9,932,190...9,977,725
Ensembl chrNW_004624766:9,934,228...9,977,697 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624746:17,044,173...17,059,295
Ensembl chrNW_004624746:17,047,519...17,054,738 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624792:9,098,291...9,128,931 JBrowse link
positive regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624788:11,772,268...11,849,040
Ensembl chrNW_004624788:11,772,396...11,845,765 		JBrowse link
G Sdc1 syndecan 1 involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624738:2,920,154...2,938,035 JBrowse link
G Sdc4 syndecan 4 involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624790:9,146,371...9,166,729
Ensembl chrNW_004624790:9,145,745...9,169,526 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624744:33,524,045...33,558,963
Ensembl chrNW_004624744:33,524,416...33,557,025 		JBrowse link
regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 NOT|involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624749:16,738,538...16,772,553
Ensembl chrNW_004624749:16,738,416...16,772,391 		JBrowse link
G Chmp6 charged multivesicular body protein 6 NOT|involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chrNW_004624801:10,063,284...10,070,322
Ensembl chrNW_004624801:10,063,614...10,070,320 		JBrowse link
regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO (PMID:24105262) UniProt PMID:24105262 NCBI chrNW_004624788:11,772,268...11,849,040
Ensembl chrNW_004624788:11,772,396...11,845,765 		JBrowse link
G Stam signal transducing adaptor molecule involved_in ISO (PMID:24105262) UniProt PMID:24105262 NCBI chrNW_004624796:10,195,897...10,269,311
Ensembl chrNW_004624796:10,201,518...10,269,311 		JBrowse link
G Tsg101 tumor susceptibility 101 involved_in ISO (PMID:24105262) UniProt PMID:24105262 NCBI chrNW_004624766:9,932,190...9,977,725
Ensembl chrNW_004624766:9,934,228...9,977,697 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    cellular process 14237
      cellular component organization or biogenesis 6217
        cellular component biogenesis 3105
          extracellular vesicle biogenesis 26
            extracellular exosome biogenesis + 24
            extracellular microvesicle biogenesis 0
paths to the root