Rab11a (RAB11A, member RAS oncogene family) - Rat Genome Database

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Gene: Rab11a (RAB11A, member RAS oncogene family) Heterocephalus glaber
Analyze
Symbol: Rab11a
Name: RAB11A, member RAS oncogene family
RGD ID: 18912405
Description: ENCODES a protein that exhibits dynein light intermediate chain binding (ortholog); G protein activity (ortholog); GTP binding (ortholog); INVOLVED IN amyloid-beta clearance by transcytosis (ortholog); astral microtubule organization (ortholog); early endosome to recycling endosome transport (ortholog); PARTICIPATES IN autophagy pathway; eicosanoid signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; ASSOCIATED WITH Bloom syndrome (ortholog); Chloracne (ortholog); colorectal cancer (ortholog); FOUND IN centriolar satellite (ortholog); centriole (ortholog); centrosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ras-related protein Rab-11A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,699,926 - 6,718,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247816,699,926 - 6,718,020 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance by transcytosis  (ISO)
astral microtubule organization  (ISO)
constitutive secretory pathway  (IEA)
early endosome to recycling endosome transport  (ISO)
establishment of protein localization to membrane  (ISO)
establishment of protein localization to organelle  (ISO)
establishment of vesicle localization  (ISO)
exocytosis  (IEA)
exosomal secretion  (ISO)
melanosome transport  (IEA)
mitotic metaphase chromosome alignment  (ISO)
mitotic spindle assembly  (ISO)
multivesicular body assembly  (ISO)
neuron projection development  (ISO)
neurotransmitter receptor transport, endosome to postsynaptic membrane  (IEA)
positive regulation of epithelial cell migration  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of mitotic cytokinetic process  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
protein localization to cell surface  (ISO)
protein localization to cilium  (ISO)
protein localization to plasma membrane  (ISO)
protein transmembrane transport  (ISO)
regulated exocytosis  (IEA)
regulation of cilium assembly  (ISO)
regulation of cytokinesis  (ISO)
regulation of early endosome to recycling endosome transport  (ISO)
regulation of endocytic recycling  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of multivesicular body size  (ISO)
regulation of protein localization to centrosome  (ISO)
regulation of protein transport  (ISO)
regulation of vesicle-mediated transport  (ISO)
vesicle-mediated transport  (ISO)
vesicle-mediated transport in synapse  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rab11a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,699,926 - 6,718,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247816,699,926 - 6,718,020 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RAB11A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381565,869,491 - 65,891,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1565,726,054 - 65,891,989 (+)EnsemblGRCh38hg38GRCh38
GRCh371566,161,829 - 66,184,327 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361563,948,850 - 63,968,846 (+)NCBINCBI36Build 36hg18NCBI36
Build 341563,948,849 - 63,968,846NCBI
Celera1543,039,718 - 43,059,714 (+)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1542,986,532 - 43,009,063 (+)NCBIHuRef
CHM1_11566,279,669 - 66,302,201 (+)NCBICHM1_1
T2T-CHM13v2.01563,678,915 - 63,701,413 (+)NCBIT2T-CHM13v2.0
Rab11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39964,622,582 - 64,645,038 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl964,622,581 - 64,645,040 (-)EnsemblGRCm39 Ensembl
GRCm38964,715,300 - 64,737,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl964,715,299 - 64,737,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv37964,563,107 - 64,585,563 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36964,514,239 - 64,535,762 (-)NCBIMGSCv36mm8
Celera961,945,730 - 61,968,176 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.87NCBI
Rab11a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8874,118,922 - 74,141,760 (-)NCBIGRCr8
mRatBN7.2865,223,698 - 65,246,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl865,222,949 - 65,246,525 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx870,737,827 - 70,760,586 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0869,010,409 - 69,033,168 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0866,880,396 - 66,903,155 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0870,192,975 - 70,215,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl870,192,975 - 70,215,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0869,896,587 - 69,919,171 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,931,925 - 68,979,514 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1868,950,978 - 68,998,568 (-)NCBI
Celera864,627,832 - 64,650,008 (-)NCBICelera
Cytogenetic Map8q24NCBI
Rab11a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554509,638,761 - 9,656,603 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554509,638,761 - 9,656,291 (-)NCBIChiLan1.0ChiLan1.0
RAB11A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21655,116,127 - 55,138,190 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11559,288,585 - 59,308,848 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01544,810,880 - 44,833,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11563,088,084 - 63,108,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1563,088,084 - 63,108,077 (+)Ensemblpanpan1.1panPan2
RAB11A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13030,200,831 - 30,218,412 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3030,200,831 - 30,218,411 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3030,128,206 - 30,145,797 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03030,390,944 - 30,408,531 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3030,390,701 - 30,412,317 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13030,320,666 - 30,338,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03030,383,756 - 30,401,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03030,624,755 - 30,642,365 (+)NCBIUU_Cfam_GSD_1.0
Rab11a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640108,241,149 - 108,264,137 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647126,088,852 - 26,113,433 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647126,089,216 - 26,111,245 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB11A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1163,858,123 - 163,891,527 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11163,858,254 - 163,887,741 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21181,463,316 - 181,492,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAB11A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12617,682,629 - 17,702,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2617,682,874 - 17,702,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048123,739,221 - 123,760,752 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000007492   ⟹   ENSHGLP00000007407
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247816,699,926 - 6,718,545 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000007493   ⟹   ENSHGLP00000007408
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247816,701,533 - 6,717,859 (-)Ensembl
RefSeq Acc Id: XM_004855611   ⟹   XP_004855668
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247816,699,926 - 6,718,020 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004855668 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA98468 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007407
  ENSHGLP00000037830
  ENSHGLP00100015190
GenBank Protein JAN96359 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004855668   ⟸   XM_004855611
- UniProtKB: G5AN52 (UniProtKB/TrEMBL),   G5B4L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000007407   ⟸   ENSHGLT00000007492
RefSeq Acc Id: ENSHGLP00000007408   ⟸   ENSHGLT00000007493


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005396 Ensembl, ENTREZGENE
  ENSHGLG00000048551 UniProtKB/TrEMBL
  ENSHGLG00100011237 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000007492 ENTREZGENE
  ENSHGLT00000090572 UniProtKB/TrEMBL
  ENSHGLT00100015357 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report hgl:101718831 UniProtKB/TrEMBL
NCBI Gene Rab11a ENTREZGENE
PANTHER DRAB11-RELATED UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-11A UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB-11B UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt G5AN52 ENTREZGENE, UniProtKB/TrEMBL
  G5B4L9 ENTREZGENE, UniProtKB/TrEMBL