global gene silencing by mRNA cleavage - Ontology Report

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Term:	global gene silencing by mRNA cleavage	go back to main search page
Accession:	GO:0098795	browse the term
Definition:	A posttranscriptional gene silencing pathway that involves the cleavage of mRNAs in a non-gene-specific manner.
Synonyms:	exact_synonym:	mRNA cleavage involved in gene silencing
	broad_synonym:	gene silencing by mRNA cleavage
	related_synonym:	RNA interference, targeting of mRNA for destruction; mRNA destabilization-mediated gene silencing; targeting of mRNA for destruction involved in RNA interference
	alt_id:	GO:0030423

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Rat (3) Mouse (3) Human (3) Chinchilla (3) Bonobo (3) Dog (3) Squirrel (3) Pig (3) Green Monkey (3) Naked Mole-rat (3) All
Genes (3)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Clp1

cleavage factor polyribonucleotide kinase subunit 1

involved_in

(PMID:17495927)
GO_REF:0000024

GO_REF:0000024

NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421

dicer 1 ribonuclease III

involved_in

(PMID:15973356), (PMID:17452327)

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

Tarbp2 subunit of RISC loading complex

involved_in

(PMID:15973356)
GO_REF:0000024
GO_REF:0000104

GO_REF:0000024 GO_REF:0000104

NCBI chr 7:133,649,118...133,654,306
Ensembl chr 7:133,649,090...133,654,314

Term paths to the root

Path 1
Term	Annotations
biological_process	19692
metabolic process	11455
negative regulation of metabolic process	3022
negative regulation of macromolecule metabolic process	2788
negative regulation of macromolecule biosynthetic process	2414
negative regulation of gene expression	1366
post-transcriptional gene silencing	271
global gene silencing by mRNA cleavage	3
Path 2
Term	Annotations
biological_process	19692
biological regulation	13305
regulation of biological process	12902
regulation of metabolic process	6482
regulation of biosynthetic process	5325
regulation of cellular biosynthetic process	5234
regulation of macromolecule biosynthetic process	5135
regulation of gene expression	5020
post-transcriptional regulation of gene expression	769
post-transcriptional gene silencing	271
global gene silencing by mRNA cleavage	3

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