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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 17 cell differentiation
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Accession:GO:0072539 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: T-helper 17 cell development

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T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:26,118,840...26,139,328
Ensembl chrNW_004624734:26,118,754...26,139,468 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in ISO (MGI:5461233|PMID:23241884) UniProt PMID:23241884 MGI:5461233 NCBI chrNW_004624737:11,361,248...11,430,476
Ensembl chrNW_004624737:11,361,737...11,428,288 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:20383124) MGI PMID:20383124 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Rora RAR related orphan receptor A involved_in ISO (MGI:3772713|PMID:18164222) GO_Central PMID:18164222 MGI:3772713 NCBI chrNW_004624781:11,014,185...11,688,558
Ensembl chrNW_004624781:11,014,286...11,679,678 		JBrowse link
G Rorc RAR related orphan receptor C involved_in
acts_upstream_of_or_within		 ISO (MGI:3692468|PMID:16990136), (MGI:3772713|PMID:18164222)
(PMID:18792410)
(PMID:20383124)		 GO_Central
MGI		 PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 MGI:3692468 MGI:3772713 NCBI chrNW_004624772:19,478,403...19,501,184
Ensembl chrNW_004624772:19,477,093...19,501,169 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) UniProt PMID:24463518 MGI:5565031 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) UniProt PMID:23169781 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Il2 interleukin 2 involved_in ISO (MGI:5634593|PMID:25642768) BHF-UCL PMID:25642768 MGI:5634593 NCBI chrNW_004624777:2,885,537...2,890,453
Ensembl chrNW_004624777:2,885,535...2,890,453 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) MGI PMID:18792410 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624760:12,025,206...12,074,548 JBrowse link
G Smad7 SMAD family member 7 involved_in ISO (MGI:5634593|PMID:25642768) BHF-UCL PMID:25642768 MGI:5634593 NCBI chrNW_004624778:12,415,364...12,444,882
Ensembl chrNW_004624778:12,415,282...12,444,835 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) UniProt PMID:21151104 MGI:4868293 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO (PMID:23034280) MGI PMID:23034280 NCBI chrNW_004624885:2,474,427...2,489,024
Ensembl chrNW_004624885:2,475,727...2,489,030 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:20,224,919...20,234,108
Ensembl chrNW_004624764:20,224,906...20,234,629 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624749:28,959,682...28,980,428
Ensembl chrNW_004624749:28,960,593...28,980,428 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) UniProt PMID:21151104 MGI:4868293 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chrNW_004624771:8,711,093...8,722,518
Ensembl chrNW_004624771:8,711,017...8,722,539 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624792:4,148,258...4,223,431
Ensembl chrNW_004624792:4,148,453...4,217,548 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624794:10,172,789...10,180,693
Ensembl chrNW_004624794:10,168,792...10,179,510 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) UniProt PMID:26098997 MGI:5689221 NCBI chrNW_004624937:564,191...584,470 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISO (MGI:6106706|PMID:28262505)
(PMID:28262505)		 UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004624754:23,742,506...23,750,668
Ensembl chrNW_004624754:23,742,509...23,750,062 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (MGI:6106706|PMID:28262505) UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004624901:2,348,218...2,434,429
Ensembl chrNW_004624901:2,346,734...2,380,852 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624802:11,662,851...11,664,444
Ensembl chrNW_004624802:11,662,753...11,665,418 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chrNW_004624843:2,017,738...2,021,153 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chrNW_004624785:12,190,802...12,203,924 JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:26,118,840...26,139,328
Ensembl chrNW_004624734:26,118,754...26,139,468 		JBrowse link
G Il6 interleukin 6 involved_in ISO (MGI:3692468|PMID:16990136)
(MGI:6142555|PMID:27893700)		 UniProt PMID:16990136 PMID:27893700 MGI:3692468 MGI:6142555 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Il6r interleukin 6 receptor involved_in ISO (MGI:6142555|PMID:27893700) UniProt PMID:27893700 MGI:6142555 NCBI chrNW_004624885:2,910,367...2,946,916
Ensembl chrNW_004624885:2,910,112...2,946,886 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (MGI:5448096|PMID:22983707) UniProt PMID:22983707 MGI:5448096 NCBI chrNW_004624756:23,917,111...23,931,482
Ensembl chrNW_004624756:23,918,323...23,931,501 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chrNW_004624893:702,895...736,623 JBrowse link
G Slamf6 SLAM family member 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624794:754,530...796,732 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO (MGI:5825383|PMID:28065600) UniProt PMID:28065600 MGI:5825383 NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      immune response 1306
        adaptive immune response 306
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 271
            T-helper 17 type immune response 43
              T-helper 17 cell differentiation 31
                T-helper 17 cell lineage commitment + 13
                negative regulation of T-helper 17 cell differentiation + 12
                positive regulation of T-helper 17 cell differentiation + 7
                regulation of T-helper 17 cell differentiation + 21
Path 2
Term Annotations click to browse term
  biological_process 15093
    developmental process 6156
      cellular developmental process 4122
        cell differentiation 4121
          cell development 2965
            hemopoiesis 926
              leukocyte differentiation 592
                mononuclear cell differentiation 482
                  lymphocyte differentiation 393
                    T cell differentiation 291
                      T cell differentiation involved in immune response 77
                        alpha-beta T cell differentiation involved in immune response 71
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 70
                            T-helper cell differentiation 68
                              T-helper 17 cell differentiation 31
                                T-helper 17 cell lineage commitment + 13
                                negative regulation of T-helper 17 cell differentiation + 12
                                positive regulation of T-helper 17 cell differentiation + 7
                                regulation of T-helper 17 cell differentiation + 21
paths to the root