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ONTOLOGY REPORT - ANNOTATIONS

Term:heteromeric SMAD protein complex
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Accession:GO:0071144 term browser browse the term
Definition:A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.
Synonyms:narrow_synonym: SMAD1-SMAD4 protein complex;   SMAD2-SMAD3-SMAD4 protein complex;   SMAD2-SMAD4 protein complex;   SMAD3-SMAD4 protein complex
 alt_id: GO:0071145;   GO:0071146


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heteromeric SMAD protein complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD1 SMAD family member 1 located_in
part_of		 IPI
IBA		 (PMID:11779505) ComplexPortal
GO_Central		 PMID:11779505 GO_REF:0000033 NCBI chr 4:145,480,770...145,559,176
Ensembl chr 4:145,481,194...145,559,176 		JBrowse link
G SMAD2 SMAD family member 2 part_of
located_in		 IDA
IBA
IEA
NAS
IPI		 (PMID:21828274)
(PMID:16322555)
(PMID:15350224)		 BHF-UCL
GO_Central
TreeGrafter
ComplexPortal		 PMID:15350224 PMID:16322555 PMID:21828274 GO_REF:0000033 GO_REF:0000118 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SMAD3 SMAD family member 3 part_of
located_in		 IDA
IEA
IBA
NAS		 (PMID:21828274)
(PMID:16322555)		 BHF-UCL
TreeGrafter
GO_Central
ComplexPortal		 PMID:16322555 PMID:21828274 GO_REF:0000033 GO_REF:0000118 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SMAD4 SMAD family member 4 located_in
part_of		 IPI
IBA
IEA
NAS		 (PMID:11779505), (PMID:15350224)
(PMID:16322555)		 ComplexPortal
GO_Central
TreeGrafter		 PMID:11779505 PMID:15350224 PMID:16322555 GO_REF:0000033 GO_REF:0000118 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045 		JBrowse link
G SMAD5 SMAD family member 5 part_of IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:136,132,845...136,182,733
Ensembl chr 5:136,132,845...136,188,747 		JBrowse link
G SMAD6 SMAD family member 6 part_of IBA GO_Central GO_REF:0000033 NCBI chr15:66,702,236...66,782,849
Ensembl chr15:66,702,236...66,782,849 		JBrowse link
G SMAD7 SMAD family member 7 part_of IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G SMAD9 SMAD family member 9 part_of IBA GO_Central GO_REF:0000033 NCBI chr13:36,844,831...36,920,854
Ensembl chr13:36,844,831...36,920,887 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20717
    protein-containing complex 7461
      SMAD protein complex 10
        heteromeric SMAD protein complex 8
Path 2
Term Annotations click to browse term
  cellular_component 20717
    cellular anatomical entity 20331
      organelle 15528
        membrane-bounded organelle 14605
          intracellular membrane-bounded organelle 13372
            nucleus 8620
              nuclear protein-containing complex 1432
                RNA polymerase II transcription regulator complex 297
                  heteromeric SMAD protein complex 8
paths to the root