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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-6-mediated signaling pathway
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Accession:GO:0070102 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: interleukin-6-mediated signalling pathway
 related_synonym: IL-6-mediated signaling pathway

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interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEBPA CCAAT enhancer binding protein alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:28,342,506...28,345,759
Ensembl chr 6:28,343,907...28,344,977 		JBrowse link
G CTR9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:54,047,922...54,077,049
Ensembl chr 1:54,047,886...54,077,338 		JBrowse link
G FER FER tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:12,252,135...12,629,584
Ensembl chr23:12,192,800...12,620,443 		JBrowse link
G GAB1 GRB2 associated binding protein 1 acts_upstream_of_or_within ISO (PMID:10779359) MGI PMID:10779359 NCBI chr 7:90,197,374...90,323,024
Ensembl chr 7:90,197,620...90,322,077 		JBrowse link
G IL6 interleukin 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1312474) Ensembl
MGI		 PMID:1312474 GO_REF:0000107 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G IL6R interleukin 6 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1312474) Ensembl
MGI		 PMID:1312474 GO_REF:0000107 NCBI chr20:9,345,723...9,418,963
Ensembl chr20:9,361,152...9,396,610 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer involved_in ISO
IEA		 RGD
Ensembl		 PMID:18280048 GO_REF:0000107 RGD:5686900 NCBI chr 4:52,174,893...52,232,475
Ensembl chr 4:52,174,312...52,214,584 		JBrowse link
G JAK1 Janus kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:68,122,134...68,253,361
Ensembl chr20:68,122,173...68,252,042 		JBrowse link
G LOC103236785 ST18 C2H2C-type zinc finger transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,214,764...48,521,428
Ensembl chr 8:48,214,374...48,319,061 		JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:29,894,157...29,951,445
Ensembl chr18:29,897,621...29,934,478 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:17,935,037...17,961,638
Ensembl chr 1:17,935,922...17,961,717 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:26,344,480...26,367,448
Ensembl chr 2:26,343,450...26,367,776 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:63,877,884...63,957,894
Ensembl chr16:63,922,862...63,957,984 		JBrowse link
G TUT4 terminal uridylyl transferase 4 involved_in ISO (PMID:19701194) UniProt PMID:19701194 NCBI chr20:80,395,484...80,522,442
Ensembl chr20:80,395,581...80,523,671 		JBrowse link
G YAP1 Yes1 associated transcriptional regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:93,479,478...93,605,340
Ensembl chr 1:93,479,135...93,606,808 		JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6ST interleukin 6 cytokine family signal transducer involved_in ISO (PMID:8353278) BHF-UCL PMID:8353278 NCBI chr 4:52,174,893...52,232,475
Ensembl chr 4:52,174,312...52,214,584 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:71,302,082...71,400,201
Ensembl chr18:71,310,577...71,345,960 		JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QTNF4 C1q and TNF related 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:17,723,720...17,730,187 JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:40,771,238...40,786,008
Ensembl chr20:40,776,816...40,783,717 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:69,065,509...69,117,825
Ensembl chr17:69,063,047...69,105,348 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17042
    cellular process 16559
      signal transduction 5610
        cell surface receptor signaling pathway 2755
          cytokine-mediated signaling pathway 519
            interleukin-6-mediated signaling pathway 19
              negative regulation of interleukin-6-mediated signaling pathway 2
              positive regulation of interleukin-6-mediated signaling pathway 3
              regulation of interleukin-6-mediated signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 17042
    response to stimulus 8784
      response to chemical 4411
        response to peptide 1156
          response to cytokine 1130
            cellular response to cytokine stimulus 1006
              cytokine-mediated signaling pathway 519
                interleukin-6-mediated signaling pathway 19
                  negative regulation of interleukin-6-mediated signaling pathway 2
                  positive regulation of interleukin-6-mediated signaling pathway 3
                  regulation of interleukin-6-mediated signaling pathway + 5
paths to the root