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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of bone remodeling
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Accession:GO:0046850 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.
Synonyms:exact_synonym: regulation of bone remodelling
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa;   NCBITaxon:7742 ! Vertebrata

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regulation of bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARTPT CART prepropeptide involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15724149) Ensembl
MGI		 PMID:15724149 GO_REF:0000107 NCBI chr 4:66,058,755...66,060,635
Ensembl chr 4:66,058,769...66,061,112 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (PMID:20053668) MGI PMID:20053668 NCBI chr27:46,958,444...46,974,032
Ensembl chr27:46,957,254...46,973,392 		JBrowse link
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21346198) Ensembl
MGI		 PMID:21346198 GO_REF:0000107 NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339 		JBrowse link
G INPP4B inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO (PMID:21982707) MGI PMID:21982707 NCBI chr 7:88,929,249...89,732,375
Ensembl chr 7:88,979,493...89,461,475 		JBrowse link
G LEP leptin involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220 		JBrowse link
G LEPR leptin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:67,454,205...67,567,524
Ensembl chr20:67,454,334...67,524,229 		JBrowse link
G MDK midkine involved_in ISO (PMID:21185956) UniProt PMID:21185956 NCBI chr 1:18,945,355...18,948,394
Ensembl chr 1:18,946,378...18,947,134 		JBrowse link
G MEPE matrix extracellular phosphoglycoprotein ISO RGD PMID:10967096 RGD:70633 NCBI chr 7:36,201,916...36,216,446 JBrowse link
G SUCO SUN domain containing ossification factor involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr25:56,541,074...56,623,086
Ensembl chr25:56,541,038...56,623,201 		JBrowse link
G SYT7 synaptotagmin 7 involved_in ISO (PMID:18539119) UniProt PMID:18539119 NCBI chr 1:12,267,591...12,333,181
Ensembl chr 1:12,267,685...12,333,185 		JBrowse link
negative regulation of bone remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GREM1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) BHF-UCL PMID:15539560 NCBI chr26:50,152,097...50,169,760 JBrowse link
G GREM1 gremlin 1, DAN family BMP antagonist involved_in IEA Ensembl GO_REF:0000107 Ensembl chr26:50,155,496...50,156,047 JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:39,243,775...39,289,050
Ensembl chr 8:39,243,780...39,288,984 		JBrowse link
negative regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARTPT CART prepropeptide involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:66,058,755...66,060,635
Ensembl chr 4:66,058,769...66,061,112 		JBrowse link
G CD38 CD38 molecule ISO RGD PMID:10477767 RGD:2307268 NCBI chr27:34,375,859...34,449,131
Ensembl chr27:34,376,271...34,449,425 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (PMID:25490771) MGI PMID:25490771 NCBI chr 6:36,708,368...36,731,729
Ensembl chr 6:36,708,311...36,730,189 		JBrowse link
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22437732) Ensembl
MGI		 PMID:22437732 GO_REF:0000107 NCBI chr15:52,509,568...52,533,205
Ensembl chr15:52,508,887...52,532,836 		JBrowse link
G CSK C-terminal Src kinase ISO RGD PMID:10411542 RGD:5134371 NCBI chr26:8,667,657...8,688,850
Ensembl chr26:8,667,655...8,688,824 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISO RGD PMID:8694895 RGD:7257714 NCBI chr26:32,074,260...32,164,926
Ensembl chr26:32,132,425...32,164,277 		JBrowse link
G FSHR follicle stimulating hormone receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11089565), (PMID:17332067) Ensembl
MGI		 PMID:11089565 PMID:17332067 GO_REF:0000107 NCBI chr14:58,013,405...58,211,528
Ensembl chr14:58,013,742...58,212,755 		JBrowse link
G GPR137 G protein-coupled receptor 137 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:9,944,971...9,949,623
Ensembl chr 1:9,944,579...9,949,624 		JBrowse link
G GPR137B G protein-coupled receptor 137B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr25:73,301,915...73,371,209
Ensembl chr25:73,302,046...73,372,569 		JBrowse link
G HAMP hepcidin antimicrobial peptide involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24561287) Ensembl
MGI		 PMID:24561287 GO_REF:0000107 NCBI chr 6:30,214,820...30,218,100
Ensembl chr 6:30,215,563...30,217,996 		JBrowse link
G IAPP islet amyloid polypeptide involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14970190) Ensembl
MGI		 PMID:14970190 GO_REF:0000107 NCBI chr11:21,240,947...21,247,409
Ensembl chr11:21,241,514...21,247,207 		JBrowse link
G IL6 interleukin 6 involved_in ISO (PMID:11159963) BHF-UCL PMID:11159963 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12161749) MGI
Ensembl
TreeGrafter		 PMID:12161749 GO_REF:0000107 GO_REF:0000118 NCBI chr10:119,093,160...119,244,128
Ensembl chr10:119,093,781...119,244,123 		JBrowse link
G LOC103239768 calcitonin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:49,946,574...49,956,010
Ensembl chr 1:49,951,694...49,954,092 		JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:12677010) MGI PMID:12677010 NCBI chr11:116,505,975...116,560,151
Ensembl chr11:116,529,346...116,563,059 		JBrowse link
G SH2D1B SH2 domain containing 1B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:1,667,247...1,684,951
Ensembl chr20:1,668,588...1,682,949 		JBrowse link
G TMEM119 transmembrane protein 119 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:103,787,911...103,796,217
Ensembl chr11:103,788,407...103,789,249 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO RGD PMID:11839361 PMID:16912914 RGD:1624170 RGD:730196 NCBI chr 8:113,520,711...113,549,370
Ensembl chr 8:113,520,596...113,548,936 		JBrowse link
G UBASH3B ubiquitin associated and SH3 domain containing B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23149425) MGI
Ensembl
TreeGrafter		 PMID:23149425 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:114,053,792...114,218,909
Ensembl chr 1:114,054,384...114,218,912 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:15312247 RGD:1580559 NCBI chr17:28,377,959...28,394,508 JBrowse link
positive regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM8 ADAM metallopeptidase domain 8 involved_in ISO (PMID:11341326)
(PMID:20683884)		 BHF-UCL PMID:11341326 PMID:20683884 NCBI chr26:53,114,184...53,129,650
Ensembl chr26:53,114,924...53,126,900 		JBrowse link
G AHSG alpha 2-HS glycoprotein ISO RGD PMID:10500999 RGD:1625797 NCBI chr15:2,809,234...2,818,382
Ensembl chr15:2,809,028...2,817,514 		JBrowse link
G CA2 carbonic anhydrase 2 ISO RGD PMID:8674544 RGD:1600722 NCBI chr 8:80,830,963...80,848,245
Ensembl chr 8:80,830,939...80,848,707 		JBrowse link
G DCSTAMP dendrocyte expressed seven transmembrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:99,174,778...99,193,539
Ensembl chr 8:99,185,423...99,193,058 		JBrowse link
G DEF8 differentially expressed in FDCP 8 homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:75,274,379...75,294,458
Ensembl chr 5:75,275,190...75,295,178 		JBrowse link
G DLK1 delta like non-canonical Notch ligand 1 acts_upstream_of_or_within ISO (PMID:21308776) MGI PMID:21308776 NCBI chr24:78,687,542...78,695,782
Ensembl chr24:78,687,668...78,695,607 		JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:2981075 RGD:10395245 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239 		JBrowse link
G FCGR3A Fc fragment of IgG receptor IIIa involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:2,466,492...2,475,579 JBrowse link
G FSHB follicle stimulating hormone subunit beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16630814) Ensembl
MGI		 PMID:16630814 GO_REF:0000107 NCBI chr 1:34,943,544...34,947,796
Ensembl chr 1:34,943,568...34,946,863 		JBrowse link
G IDUA alpha-L-iduronidase acts_upstream_of_or_within ISO (PMID:19834056) MGI PMID:19834056 NCBI chr27:47,778,220...47,794,435
Ensembl chr27:47,778,335...47,794,352 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO RGD PMID:8603604 RGD:5024929 NCBI chr16:59,372,171...59,431,434
Ensembl chr16:59,374,889...59,410,857 		JBrowse link
G LRP6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:18505367) MGI PMID:18505367 NCBI chr11:12,016,542...12,170,496
Ensembl chr11:12,021,560...12,170,663 		JBrowse link
G LTBP3 latent transforming growth factor beta binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15878314) Ensembl
MGI		 PMID:15878314 GO_REF:0000107 NCBI chr 1:8,681,140...8,700,721
Ensembl chr 1:8,681,156...8,703,740 		JBrowse link
G MC4R melanocortin 4 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:19,380,054...19,386,412
Ensembl chr18:19,380,849...19,381,847 		JBrowse link
G OSCAR osteoclast associated Ig-like receptor acts_upstream_of_or_within ISO (PMID:11805147) MGI PMID:11805147 NCBI chr 6:46,772,335...46,777,606 JBrowse link
G OSCAR osteoclast associated Ig-like receptor involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:46,773,185...46,777,298 JBrowse link
G PLEKHM1 pleckstrin homology and RUN domain containing M1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:60,926,006...60,980,359
Ensembl chr16:60,926,063...60,980,669 		JBrowse link
G PPARGC1B PPARG coactivator 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:52,337,802...52,462,553
Ensembl chr23:52,428,052...52,455,089 		JBrowse link
G PRKCA protein kinase C alpha involved_in ISO (PMID:16014375) BHF-UCL PMID:16014375 NCBI chr16:54,638,548...55,144,372
Ensembl chr16:54,642,729...54,948,256 		JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:11792579 RGD:729815 NCBI chr 4:39,440,697...39,453,983
Ensembl chr 4:39,440,276...39,454,004 		JBrowse link
G SPP1 secreted phosphoprotein 1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:11792563 GO_REF:0000118 RGD:1581129 NCBI chr 7:36,337,165...36,344,927
Ensembl chr 7:36,338,386...36,344,407 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:8514886 RGD:150524326 NCBI chr 2:26,344,480...26,367,448
Ensembl chr 2:26,343,450...26,367,776 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:101,254,085...101,374,724
Ensembl chr12:101,260,061...101,349,856 		JBrowse link
G TF transferrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:56,586,311...56,618,304
Ensembl chr15:56,586,104...56,618,149 		JBrowse link
G TFRC transferrin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:91,102,153...91,134,994
Ensembl chr15:91,102,817...91,135,584 		JBrowse link
G TMEM64 transmembrane protein 64 acts_upstream_of_or_within ISO (PMID:23395171) MGI PMID:23395171 NCBI chr 8:85,706,631...85,730,966 JBrowse link
G TNFRSF11A TNF receptor superfamily member 11a involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11805147) Ensembl
TreeGrafter
MGI		 PMID:11805147 GO_REF:0000107 GO_REF:0000118 NCBI chr18:17,385,251...17,446,442 JBrowse link
G TNFSF11 TNF superfamily member 11 involved_in ISO
IEA		 RGD
Ensembl		 PMID:11092398 GO_REF:0000107 RGD:730134 NCBI chr 3:20,717,884...20,761,520
Ensembl chr 3:20,727,592...20,760,408 		JBrowse link
regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCR calcitonin receptor NOT|acts_upstream_of_or_within ISO (PMID:14970190) MGI PMID:14970190 NCBI chr21:55,433,438...55,585,608
Ensembl chr21:55,523,412...55,583,735 		JBrowse link
G CSF1R colony stimulating factor 1 receptor involved_in ISO PMID:17121910 UniProt PMID:17121910 RGD:2293713 NCBI chr23:52,663,290...52,723,652
Ensembl chr23:52,664,076...52,697,304 		JBrowse link
G IL20RA interleukin 20 receptor subunit alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21844205) MGI
Ensembl		 PMID:21844205 GO_REF:0000107 NCBI chr13:36,351,873...36,397,300
Ensembl chr13:36,352,018...36,397,302 		JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within ISO (PMID:17053831) MGI PMID:17053831 NCBI chr16:24,550,983...24,836,311
Ensembl chr16:24,550,977...24,836,307 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:53,445,607...53,458,729
Ensembl chr21:53,445,457...53,460,776 		JBrowse link
G S1PR1 sphingosine-1-phosphate receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:32,109,436...32,117,015
Ensembl chr20:32,110,819...32,111,967 		JBrowse link
G SIGLEC15 sialic acid binding Ig like lectin 15 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22451653) MGI
Ensembl
TreeGrafter		 PMID:22451653 GO_REF:0000107 GO_REF:0000118 NCBI chr18:35,070,459...35,087,525 JBrowse link
G SLC4A2 solute carrier family 4 member 2 involved_in ISO (PMID:23341620) UniProt PMID:23341620 NCBI chr21:119,240,352...119,258,920
Ensembl chr21:119,241,490...119,263,193 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17022
    multicellular organismal process 7453
      tissue remodeling 230
        regulation of tissue remodeling 92
          regulation of bone remodeling 68
            negative regulation of bone remodeling + 23
            positive regulation of bone remodeling 0
            regulation of bone resorption + 56
Path 2
Term Annotations click to browse term
  biological_process 17022
    biological regulation 11823
      regulation of biological process 11434
        regulation of multicellular organismal process 3218
          regulation of tissue remodeling 92
            regulation of bone remodeling 68
              negative regulation of bone remodeling + 23
              positive regulation of bone remodeling 0
              regulation of bone resorption + 56
paths to the root