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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of bone resorption
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Accession:GO:0045124 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).


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regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcr calcitonin receptor NOT
NOT|acts_upstream_of_or_within
ISO MGI:3038975 (MGI:3037515|PMID:14970190) RGD PMID:14970190 MGI:3037515 NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
JBrowse link
G Car2 carbonic anhydrase 2 TAS RGD PMID:9665810 RGD:1342423 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Csf1r colony stimulating factor 1 receptor involved_in IMP PMID:17121910 UniProt PMID:17121910, PMID:17121910 RGD:2293713, RGD:2293713 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Il20ra interleukin 20 receptor subunit alpha acts_upstream_of_or_within ISO MGI:5302406 (MGI:5296273|PMID:21844205) RGD PMID:21844205 MGI:5296273 NCBI chr 1:15,180,328...15,222,785
Ensembl chr 1:15,180,328...15,222,785
JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within
involved_in
IEA
ISO
ISS
GO_REF:0000107
MGI:1857478 (MGI:3689489|PMID:17053831)
GO_REF:0000024
Ensembl
RGD
HGNC-UCL
HGNC
PMID:17053831 GO_REF:0000024 GO_REF:0000107 MGI:3689489 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:5303050|PMID:21803180)
Ensembl
RGD
PMID:21803180 GO_REF:0000107 MGI:5303050 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3839226|PMID:19204730)
UniProt
RGD
PMID:19204730 GO_REF:0000024 MGI:3839226 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G Siglec15 sialic acid binding Ig-like lectin 15 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:5467208|PMID:22451653)
PMID:21873635
RGD PMID:22451653, PMID:21873635, PMID:21873635 MGI:5467208, RGD:13792537, RGD:13792537 NCBI chr18:74,403,384...74,417,333
Ensembl chr18:74,403,384...74,417,333
JBrowse link
negative regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha involved_in ISO
IEA
(PMID:10822112)
GO_REF:0000107
(PMID:17241109)
RGD
Ensembl
PMID:10822112 PMID:17241109 GO_REF:0000107 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cartpt CART prepropeptide involved_in ISO (PMID:16614075)
UniProtKB:P56450 (MGI:3696590|PMID:16614075)
RGD PMID:16614075 MGI:3696590 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Cd38 CD38 molecule IDA RGD PMID:10477767 RGD:2307268 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO MGI:5560663 (MGI:5691608|PMID:25490771) RGD PMID:25490771 MGI:5691608 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cldn18 claudin 18 acts_upstream_of_or_within ISO MGI:5007067 (MGI:5489769|PMID:22437732) RGD PMID:22437732 MGI:5489769 NCBI chr 8:107,933,725...107,960,656
Ensembl chr 8:107,934,860...107,952,530
JBrowse link
G Csk C-terminal Src kinase IDA RGD PMID:10411542 RGD:5134371 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IMP RGD PMID:8694895 RGD:7257714 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Fshr follicle stimulating hormone receptor acts_upstream_of_or_within ISO MGI:2384087 (MGI:1926755|PMID:11089565), (MGI:3769858|PMID:17332067) RGD PMID:11089565 PMID:17332067 MGI:1926755 MGI:3769858 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Gpr137 G protein-coupled receptor 137 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 1:222,194,266...222,197,252
Ensembl chr 1:222,194,266...222,197,252
JBrowse link
G Gpr137b G protein-coupled receptor 137B involved_in ISO
IBA
(MGI:6362357|PMID:31173907)
PMID:21873635
RGD PMID:31173907, PMID:21873635, PMID:21873635 MGI:6362357, RGD:13792537, RGD:13792537 NCBI chr17:90,670,852...90,709,003
Ensembl chr17:90,670,872...90,746,804
JBrowse link
G Hamp hepcidin antimicrobial peptide acts_upstream_of_or_within ISO MGI:4351741 (MGI:5581387|PMID:24561287) RGD PMID:24561287 MGI:5581387 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Iapp islet amyloid polypeptide acts_upstream_of_or_within ISO MGI:2656235 (MGI:3037515|PMID:14970190) RGD PMID:14970190 MGI:3037515 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
JBrowse link
G Il6 interleukin 6 involved_in ISO (MGI:5795829|PMID:11159963) RGD PMID:11159963 MGI:5795829 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in
IEA
ISO
GO_REF:0000107
MGI:2386884 (MGI:2386137|PMID:12161749)
Ensembl
RGD
PMID:12161749 GO_REF:0000107 MGI:2386137 NCBI chr 9:94,745,220...94,850,778
Ensembl chr 9:94,745,217...94,850,771
JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (MGI:2667237|PMID:12677010) RGD PMID:12677010 MGI:2667237 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Tmem119 transmembrane protein 119 involved_in ISO (MGI:5543589|PMID:22416756) RGD PMID:22416756 MGI:5543589 NCBI chr12:48,598,498...48,605,704
Ensembl chr12:48,598,647...48,605,704
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B IMP
IDA
RGD PMID:11839361, PMID:16912914 RGD:730196, RGD:1624170 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:5619442|PMID:23149425)
PMID:21873635
RGD PMID:23149425, PMID:21873635, PMID:21873635 MGI:5619442, RGD:13792537, RGD:13792537 NCBI chr 8:45,224,053...45,375,450
Ensembl chr 8:45,223,992...45,375,435
JBrowse link
G Vegfa vascular endothelial growth factor A IMP RGD PMID:15312247 RGD:1580559 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
positive regulation of bone resorption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 involved_in ISO (MGI:5009189|PMID:11341326), (MGI:5009349|PMID:20683884) RGD PMID:11341326 PMID:20683884 MGI:5009189 MGI:5009349 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
JBrowse link
G Ahsg alpha-2-HS-glycoprotein IMP RGD PMID:10500999 RGD:1625797 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5575464|PMID:22467241)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22467241 GO_REF:0000024 GO_REF:0000107 MGI:5575464 NCBI chr  X:156,407,973...156,415,053
Ensembl chr  X:156,407,937...156,415,145
JBrowse link
G Car2 carbonic anhydrase 2 IMP RGD PMID:8674544 RGD:1600722 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein involved_in ISO (MGI:3588832|PMID:16061724), (MGI:5426134|PMID:17164993), (MGI:5426135|PMID:16937266) RGD PMID:16061724 PMID:16937266 PMID:17164993 MGI:3588832 MGI:5426134 MGI:5426135 NCBI chr 7:78,642,016...78,651,763
Ensembl chr 7:78,649,875...78,650,906
JBrowse link
G Def8 differentially expressed in FDCP 8 homolog involved_in ISS
ISO
GO_REF:0000024
(MGI:5806241|PMID:27777970)
UniProt
RGD
PMID:27777970 GO_REF:0000024 MGI:5806241 NCBI chr19:56,238,353...56,259,867
Ensembl chr19:56,243,408...56,259,196
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 acts_upstream_of_or_within ISO MGI:3526402 (MGI:5780798|PMID:21308776) RGD PMID:21308776 MGI:5780798 NCBI chr 6:133,576,513...133,583,751
Ensembl chr 6:133,552,821...133,583,751
JBrowse link
G Egfr epidermal growth factor receptor IMP RGD PMID:2981075 RGD:10395245 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fcgr3a Fc fragment of IgG receptor IIIa involved_in ISO (MGI:5641770|PMID:25824719) RGD PMID:25824719 MGI:5641770 NCBI chr13:89,385,775...89,396,047
Ensembl chr13:89,385,859...89,396,051
JBrowse link
G Fshb follicle stimulating hormone subunit beta acts_upstream_of_or_within ISO MGI:1857434 (MGI:3692338|PMID:16630814) RGD PMID:16630814 MGI:3692338 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2176236 (MGI:4397742|PMID:19834056) RGD PMID:19834056 MGI:4397742 NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762
JBrowse link
G Itgb3 integrin subunit beta 3 IMP RGD PMID:8603604 RGD:5024929 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2673982 (MGI:4365357|PMID:18505367) RGD PMID:18505367 MGI:4365357 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (MGI:3719740|PMID:15878314) RGD PMID:15878314 MGI:3719740 NCBI chr 1:221,099,155...221,116,096
Ensembl chr 1:221,099,998...221,116,096
JBrowse link
G Mc4r melanocortin 4 receptor involved_in ISO (PMID:16614075)
(MGI:3696590|PMID:16614075)
RGD PMID:16614075 MGI:3696590 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
JBrowse link
G Oscar osteoclast associated Ig-like receptor acts_upstream_of_or_within ISO (MGI:2178877|PMID:11805147) RGD PMID:11805147 MGI:2178877 NCBI chr 1:64,182,174...64,188,658
Ensembl chr 1:64,182,422...64,188,658
JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5806241|PMID:27777970)
UniProt
RGD
PMID:27777970 GO_REF:0000024 MGI:5806241 NCBI chr10:91,451,890...91,500,675
Ensembl chr10:91,451,865...91,500,661
JBrowse link
G Ppargc1b PPARG coactivator 1 beta involved_in ISO (MGI:3838421|PMID:19252502) RGD PMID:19252502 MGI:3838421 NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
JBrowse link
G Prkca protein kinase C, alpha involved_in ISO (MGI:5284791|PMID:16014375) RGD PMID:16014375 MGI:5284791 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11792579 RGD:729815 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Spp1 secreted phosphoprotein 1 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:11792563, PMID:21873635, PMID:21873635 RGD:1581129, RGD:13792537, RGD:13792537 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3703840|PMID:17353363)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17353363 GO_REF:0000024 GO_REF:0000107 MGI:3703840 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Tf transferrin involved_in ISO (MGI:3838421|PMID:19252502) RGD PMID:19252502 MGI:3838421 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfrc transferrin receptor involved_in ISO (MGI:3838421|PMID:19252502) RGD PMID:19252502 MGI:3838421 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tmem64 transmembrane protein 64 acts_upstream_of_or_within ISO MGI:3880885 (MGI:5495340|PMID:23395171) RGD PMID:23395171 MGI:5495340 NCBI chr 5:28,850,864...28,898,203
Ensembl chr 5:28,850,950...28,867,227
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:2178877|PMID:11805147)
PMID:21873635
RGD PMID:11805147, PMID:21873635, PMID:21873635 MGI:2178877, RGD:13792537, RGD:13792537 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfsf11 TNF superfamily member 11 involved_in IMP
ISO
(PMID:17241109) RGD PMID:17241109, PMID:11092398 RGD:730134 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20082
    biological regulation 13906
      regulation of biological quality 4328
        regulation of bone resorption 53
          negative regulation of bone resorption 19
          positive regulation of bone resorption 27
Path 2
Term Annotations click to browse term
  biological_process 20082
    biological regulation 13906
      regulation of biological quality 4328
        homeostatic process 2098
          multicellular organismal homeostasis 558
            tissue homeostasis 288
              bone resorption 80
                regulation of bone resorption 53
                  negative regulation of bone resorption 19
                  positive regulation of bone resorption 27
paths to the root