GREM1 (gremlin 1, DAN family BMP antagonist) - Rat Genome Database

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Gene: GREM1 (gremlin 1, DAN family BMP antagonist) Chlorocebus sabaeus
Analyze
Symbol: GREM1
Name: gremlin 1, DAN family BMP antagonist
RGD ID: 20867511
Description: ENCODES a protein that exhibits BMP binding (inferred); cytokine activity (inferred); protein homodimerization activity (inferred); INVOLVED IN angiogenesis (inferred); animal organ morphogenesis (inferred); cardiac muscle cell differentiation (inferred); FOUND IN cell surface (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
Latest Assembly: ChlSab1.1 Ensembl - Green Monkey 1.1 Assembly Ensembl
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2650,155,496 - 50,156,047 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
animal organ morphogenesis  (IEA)
cardiac muscle cell differentiation  (IEA)
cardiac muscle cell myoblast differentiation  (IEA)
cell migration involved in sprouting angiogenesis  (IEA)
cell morphogenesis  (IEA)
cell-cell signaling  (IEA)
collagen fibril organization  (IEA)
determination of dorsal identity  (IEA)
embryonic limb morphogenesis  (IEA)
endothelial cell migration  (IEA)
limb development  (IEA)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of BMP signaling pathway  (IEA)
negative regulation of bone mineralization  (IEA)
negative regulation of bone mineralization involved in bone maturation  (IEA)
negative regulation of bone remodeling  (IEA)
negative regulation of bone trabecula formation  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of chondrocyte differentiation  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of osteoblast differentiation  (IEA)
negative regulation of osteoblast proliferation  (IEA)
negative regulation of osteoclast proliferation  (IEA)
negative regulation of SMAD protein signal transduction  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of peptidyl-tyrosine autophosphorylation  (IEA)
positive regulation of receptor internalization  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
proximal/distal pattern formation  (IEA)
regulation of epithelial to mesenchymal transition  (IEA)
regulation of focal adhesion assembly  (IEA)
sequestering of BMP from receptor via BMP binding  (IEA)
signal transduction  (IEA)
ureteric bud formation  (IEA)

Cellular Component

References

Genomics


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 20 17 60
Below cutoff 13 3

Sequence

Nucleotide Sequences

Reference Sequences
RefSeq Acc Id: ENSCSAT00000019846   ⟹   ENSCSAP00000019251
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2650,155,496 - 50,156,047 (-)Ensembl
Protein Sequences
Ensembl Protein ENSCSAP00000019251.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000019251   ⟸   ENSCSAT00000019846


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000019756 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000019846.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  DAN UniProtKB/TrEMBL
  Gremlin-1/2 UniProtKB/TrEMBL
PANTHER GREMLIN 1 UniProtKB/TrEMBL
  GREMLIN-1 UniProtKB/TrEMBL
Pfam DAN UniProtKB/TrEMBL
PIRSF Gremlin_precursor UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
UniProt A0A0D9SEG2_CHLSB UniProtKB/TrEMBL