IAPP (islet amyloid polypeptide) - Rat Genome Database
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Gene: IAPP (islet amyloid polypeptide) Chlorocebus sabaeus
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Symbol: IAPP
Name: islet amyloid polypeptide
RGD ID: 18781380
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); amylin receptor signaling pathway (ortholog); amyloid fibril formation (ortholog); ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); gastric ulcer (ortholog); type 1 diabetes mellitus (ortholog); FOUND IN extracellular space (ortholog); inclusion body (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Orthologs:
Homo sapiens (human) : IAPP (islet amyloid polypeptide)  HGNC  Alliance
Mus musculus (house mouse) : Iapp (islet amyloid polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Iapp (islet amyloid polypeptide)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Iapp (islet amyloid polypeptide)
Pan paniscus (bonobo/pygmy chimpanzee) : IAPP (islet amyloid polypeptide)
Canis lupus familiaris (dog) : IAPP (islet amyloid polypeptide)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Iapp (islet amyloid polypeptide)
Sus scrofa (pig) : IAPP (islet amyloid polypeptide)
Heterocephalus glaber (naked mole-rat) : Iapp (islet amyloid polypeptide)
more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1121,241,514 - 21,247,207 (+)Ensembl
ChlSab1.11121,240,947 - 21,247,409 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Genomics

Comparative Map Data
IAPP
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1121,241,514 - 21,247,207 (+)Ensembl
ChlSab1.11121,240,947 - 21,247,409 (+)NCBI
IAPP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1221,354,959 - 21,379,980 (+)EnsemblGRCh38hg38GRCh38
GRCh381221,354,959 - 21,379,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371221,525,802 - 21,532,914 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,417,085 - 21,423,683 (+)NCBINCBI36hg18NCBI36
Build 341221,417,084 - 21,423,683NCBI
Celera1226,681,196 - 26,688,308 (+)NCBI
Cytogenetic Map12p12.1NCBI
HuRef1221,299,907 - 21,307,017 (+)NCBIHuRef
CHM1_11221,491,270 - 21,498,381 (+)NCBICHM1_1
Iapp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,244,151 - 142,249,546 (+)NCBI
GRCm386142,298,425 - 142,303,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,298,423 - 142,303,961 (+)EnsemblGRCm38mm10GRCm38
MGSCv376142,246,945 - 142,252,340 (+)NCBIGRCm37mm9NCBIm37
MGSCv366142,255,650 - 142,261,039 (+)NCBImm8
Celera6145,357,925 - 145,363,320 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map673.81NCBI
Iapp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04176,509,863 - 176,517,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,510,696 - 176,516,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,723,950 - 240,731,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44179,855,956 - 179,860,871 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14180,100,696 - 180,106,512 (+)NCBI
Celera4163,770,383 - 163,775,298 (+)NCBICelera
Cytogenetic Map4q44NCBI
RH 3.4 Map41043.4RGD
Iapp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541316,835,037 - 16,840,682 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541316,834,940 - 16,841,071 (-)NCBIChiLan1.0ChiLan1.0
IAPP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11267,520,986 - 67,528,103 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,520,986 - 67,528,103 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01264,918,000 - 64,925,191 (-)NCBIMhudiblu_PPA_v0panPan3
IAPP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2726,295,481 - 26,299,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12726,295,481 - 26,299,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Iapp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365485,463,829 - 5,469,136 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IAPP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl552,046,573 - 52,050,446 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1552,046,570 - 52,051,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,323,381 - 55,327,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Iapp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475217,528,214 - 17,594,622 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 11 11
Low 9 9 10
Below cutoff 8 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007967862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AQIB01128438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000006040   ⟹   ENSCSAP00000004291
RefSeq Status:
Type: CODING
Position:
Vervet AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1121,241,514 - 21,247,207 (+)Ensembl
RefSeq Acc Id: XM_007967862   ⟹   XP_007966053
RefSeq Status:
Type: CODING
Position:
Vervet AssemblyChrPosition (strand)Source
ChlSab1.11121,240,947 - 21,247,409 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007966053 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_007966053   ⟸   XM_007967862
- UniProtKB: A0A0D9R6Q2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000004291   ⟸   ENSCSAT00000006040


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007986 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCSAP00000004291 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006040 ENTREZGENE, UniProtKB/TrEMBL
InterPro Calcitonin-like UniProtKB/TrEMBL
  Calcitonin/adrenomedullin UniProtKB/TrEMBL
  Calcitonin_CS UniProtKB/TrEMBL
  Calcitonin_peptide-like UniProtKB/TrEMBL
  Pro-islet_amyloid_polypep UniProtKB/TrEMBL
KEGG Report csab:103218731 UniProtKB/TrEMBL
NCBI Gene IAPP ENTREZGENE
PANTHER PTHR10505 UniProtKB/TrEMBL
  PTHR10505:SF4 UniProtKB/TrEMBL
Pfam Calc_CGRP_IAPP UniProtKB/TrEMBL
PRINTS ISLETAMYLOID UniProtKB/TrEMBL
PROSITE CALCITONIN UniProtKB/TrEMBL
SMART CALCITONIN UniProtKB/TrEMBL
UniProt A0A0D9R6Q2 ENTREZGENE, UniProtKB/TrEMBL