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ONTOLOGY REPORT - ANNOTATIONS

Term:sphingosine biosynthetic process
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Accession:GO:0046512 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
Synonyms:exact_synonym: sphingosine anabolism;   sphingosine biosynthesis;   sphingosine formation;   sphingosine synthesis

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sphingosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of_positive_effect ISO (PMID:26510981) ARUK-UCL PMID:26510981 NCBI chrNW_004624760:880,216...898,753
Ensembl chrNW_004624760:880,148...898,751 		JBrowse link
G Acer1 alkaline ceramidase 1 involved_in IEA TreeGrafter
UniProt		 GO_REF:0000117 GO_REF:0000118 NCBI chrNW_004624828:4,022,288...4,046,235
Ensembl chrNW_004624828:4,041,875...4,045,675 		JBrowse link
G Acer2 alkaline ceramidase 2 involved_in IEA TreeGrafter
UniProt		 GO_REF:0000117 GO_REF:0000118 NCBI chrNW_004624736:23,363,806...23,556,247
Ensembl chrNW_004624736:23,363,983...23,411,100 		JBrowse link
G Acer3 alkaline ceramidase 3 involved_in IEA UniProt GO_REF:0000117 NCBI chrNW_004624863:37,148...96,550
Ensembl chrNW_004624863:37,148...95,211 		JBrowse link
G Agk acylglycerol kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624765:21,572,797...21,666,424
Ensembl chrNW_004624765:21,572,714...21,668,516 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISO (PMID:12815059)
(PMID:10610716)
(MGI:1267186|PMID:9653654)
(PMID:9653654)		 UniProt PMID:9653654 PMID:10610716 PMID:12815059 MGI:1267186 NCBI chrNW_004624769:21,112,705...21,140,004
Ensembl chrNW_004624769:21,112,851...21,138,831 		JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624791:12,906,908...13,059,033
Ensembl chrNW_004624791:12,907,485...13,059,005 		JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO (PMID:19279011) BHF-UCL PMID:19279011 NCBI chrNW_004624885:2,315,371...2,321,327
Ensembl chrNW_004624885:2,315,142...2,321,327 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624801:6,253,219...6,257,128 JBrowse link
G Sphk2 sphingosine kinase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624832:5,246,328...5,254,247
Ensembl chrNW_004624832:5,246,895...5,253,207 		JBrowse link
G Sptlc1 serine palmitoyltransferase long chain base subunit 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16216550) MGI
TreeGrafter		 PMID:16216550 GO_REF:0000118 NCBI chrNW_004624868:317,992...393,776
Ensembl chrNW_004624868:318,059...393,773 		JBrowse link
G Sptlc2 serine palmitoyltransferase long chain base subunit 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16216550) TreeGrafter
MGI		 PMID:16216550 GO_REF:0000118 NCBI chrNW_004624734:24,281,482...24,400,870 JBrowse link
G Sptlc3 serine palmitoyltransferase long chain base subunit 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624741:13,956,688...14,152,127
Ensembl chrNW_004624741:13,956,570...14,152,600 		JBrowse link
G Sptssa serine palmitoyltransferase small subunit A involved_in ISO (PMID:19416851), (PMID:33558761) ComplexPortal PMID:19416851 PMID:33558761 NCBI chrNW_004624838:2,207,003...2,231,838
Ensembl chrNW_004624838:2,206,917...2,231,518 		JBrowse link
G Sptssb serine palmitoyltransferase small subunit B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624730:39,280,846...39,324,174
Ensembl chrNW_004624730:39,291,652...39,323,139 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15258
    cellular process 14889
      metabolic process 9701
        small molecule metabolic process 1536
          alcohol metabolic process 301
            polyol metabolic process 107
              diol metabolic process 33
                sphingosine metabolic process 22
                  sphingosine biosynthetic process 15
Path 2
Term Annotations click to browse term
  biological_process 15258
    cellular process 14889
      metabolic process 9701
        primary metabolic process 8629
          lipid metabolic process 1187
            membrane lipid metabolic process 187
              sphingolipid metabolic process 142
                sphingoid metabolic process 24
                  sphingosine metabolic process 22
                    sphingosine biosynthetic process 15
paths to the root