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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingosine metabolic process
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Accession:GO:0006670 term browser browse the term
Definition:The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
Synonyms:exact_synonym: (4E)-sphing-4-enine metabolic process;   (4E)-sphing-4-enine metabolism;   sphing-4-enine metabolic process;   sphing-4-enine metabolism;   sphingosine metabolism



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sphingosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in ISO
ISS
(PMID:10781606), (PMID:15946935), (PMID:16229686), (PMID:17475390), (PMID:26190575)
GO_REF:0000024
RGD
UniProt
PMID:10781606 PMID:15946935 PMID:16229686 PMID:17475390 PMID:26190575 GO_REF:0000024 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
JBrowse link
G Naaa N-acylethanolamine acid amidase involved_in ISO
ISS
(PMID:15655246)
GO_REF:0000024
RGD
UniProt
PMID:15655246 GO_REF:0000024 NCBI chr14:15,777,306...15,796,411
Ensembl chr14:15,777,306...15,796,410
JBrowse link
G Plpp1 phospholipid phosphatase 1 involved_in IDA
ISO
PMID:10359651
(MGI:6383560|PMID:10359651)
PMID:8663293
(PMID:9705349)
RGD PMID:9705349 PMID:10359651 PMID:10359651 PMID:8663293 MGI:6383560, RGD:15090857, RGD:15090855 NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268
JBrowse link
G Plpp2 phospholipid phosphatase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:9705349)
UniProt
RGD
PMID:9705349 GO_REF:0000024 NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071
JBrowse link
G Plpp3 phospholipid phosphatase 3 involved_in ISO
IEA
ISS
(PMID:9305923), (PMID:9705349)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:9305923 PMID:9705349 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(MGI:2176350|PMID:11756451)
Ensembl
RGD
PMID:11756451 PMID:21873635 GO_REF:0000107 MGI:2176350, RGD:13792537 NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534
JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 involved_in ISO
IBA
(PMID:12411432)
PMID:21873635
RGD PMID:12411432 PMID:21873635 RGD:13792537 NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
ISS
(PMID:20577214)
GO_REF:0000024
RGD
UniProt
PMID:20577214 GO_REF:0000024 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in
acts_upstream_of_or_within
ISO (MGI:3703830|PMID:17346996)
MGI:3580701 (MGI:3608224|PMID:16093248)
RGD PMID:16093248 PMID:17346996 MGI:3608224 MGI:3703830 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
sphingosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of_positive_effect
involved_in
ISO
IEA
(PMID:26510981)
GO_REF:0000107
RGD
Ensembl
PMID:26510981 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Acer1 alkaline ceramidase 1 involved_in ISO
IBA
(PMID:17713573), (PMID:20207939), (PMID:20628055)
(MGI:5800647|PMID:27126290), (MGI:6107252|PMID:29056331)
PMID:21873635
RGD PMID:17713573 PMID:20207939 PMID:20628055 PMID:27126290 PMID:29056331 More... MGI:5800647 MGI:6107252, RGD:13792537 NCBI chr 9:1,792,790...1,824,434
Ensembl chr 9:1,793,139...1,824,434
JBrowse link
G Acer2 alkaline ceramidase 2 involved_in ISO
IBA
(PMID:16940153), (PMID:20089856), (PMID:20207939), (PMID:20628055)
(MGI:6116621|PMID:29401619)
PMID:21873635
RGD PMID:16940153 PMID:20089856 PMID:20207939 PMID:20628055 PMID:29401619 More... MGI:6116621, RGD:13792537 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
JBrowse link
G Acer3 alkaline ceramidase 3 involved_in ISO (PMID:20068046), (PMID:20207939), (PMID:26792856)
(MGI:5749603|PMID:26474409)
RGD PMID:20068046 PMID:20207939 PMID:26474409 PMID:26792856 MGI:5749603 NCBI chr 1:152,504,180...152,606,596
Ensembl chr 1:152,504,186...152,606,591
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:10610716), (PMID:12815059)
(MGI:1267186|PMID:9653654)
UniProt
Ensembl
RGD
PMID:9653654 PMID:10610716 PMID:12815059 GO_REF:0000024 GO_REF:0000107 MGI:1267186 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in IDA
ISO
IBA
PMID:10488143
(PMID:30154232)
PMID:21873635
PMID:15217782
(MGI:3608219|PMID:16126722), (MGI:3640407|PMID:16380386), (MGI:6275120|PMID:10652340)
PMID:15123644
RGD PMID:10652340 PMID:16126722 PMID:16380386 PMID:30154232 PMID:10488143 More... MGI:3608219 MGI:3640407 MGI:6275120, RGD:13838800, RGD:13792537, RGD:13838794, RGD:13838793 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
JBrowse link
G ENSRNOG00000069695 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 Ensembl chr14:25,729,638...25,730,194 JBrowse link
G Gba glucosylceramidase beta involved_in ISO (PMID:19279011) RGD PMID:19279011 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
IBA
IEA
UniProtKB:Q9NRA0 (PMID:23106337)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:23106337 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO
IBA
UniProtKB:Q9NYA1 (PMID:23106337)
PMID:21873635
RGD PMID:23106337 PMID:21873635 RGD:13792537 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:3815115 (MGI:3814228|PMID:16216550)
(PMID:19416851), (PMID:33558761)
PMID:21873635
RGD PMID:16216550 PMID:19416851 PMID:33558761 PMID:21873635 MGI:3814228, RGD:13792537 NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
MGI:3815117 (MGI:3814228|PMID:16216550)
(PMID:19416851), (PMID:33558761)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:16216550 PMID:19416851 PMID:33558761 PMID:21873635 GO_REF:0000107 MGI:3814228, RGD:13792537 NCBI chr 6:106,948,681...107,031,584
Ensembl chr 6:106,950,949...107,031,542
JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 involved_in ISO
IBA
(PMID:19416851)
PMID:21873635
RGD PMID:19416851 PMID:21873635 RGD:13792537 NCBI chr 3:126,847,878...126,978,010
Ensembl chr 3:126,847,878...126,978,010
JBrowse link
G Sptssa serine palmitoyltransferase, small subunit A involved_in ISO (PMID:19416851), (PMID:33558761) RGD PMID:19416851 PMID:33558761 NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214
JBrowse link
G Sptssb serine palmitoyltransferase, small subunit B involved_in ISO (PMID:19416851) RGD PMID:19416851 NCBI chr 2:154,133,728...154,162,127
Ensembl chr 2:154,133,733...154,163,120
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      nitrogen compound metabolic process 10574
        organonitrogen compound metabolic process 7282
          sphingolipid metabolic process 153
            sphingoid metabolic process 23
              sphingosine metabolic process 21
                sphingosine biosynthetic process 15
                sphingosine catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      organic substance metabolic process 11873
        lipid metabolic process 1446
          cellular lipid metabolic process 1057
            membrane lipid metabolic process 202
              sphingolipid metabolic process 153
                sphingoid metabolic process 23
                  sphingosine metabolic process 21
                    sphingosine biosynthetic process 15
                    sphingosine catabolic process 0
paths to the root