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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingosine metabolic process
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Accession:GO:0006670 term browser browse the term
Definition:The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
Synonyms:exact_synonym: (4E)-sphing-4-enine metabolic process;   (4E)-sphing-4-enine metabolism;   sphing-4-enine metabolic process;   sphing-4-enine metabolism;   sphingosine metabolism


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sphingosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in ISO
ISS
(PMID:10781606), (PMID:15946935), (PMID:16229686), (PMID:17475390), (PMID:26190575)
GO_REF:0000024
RGD
UniProt
PMID:10781606 PMID:15946935 PMID:16229686 PMID:17475390 PMID:26190575 GO_REF:0000024 NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
JBrowse link
G Naaa N-acylethanolamine acid amidase involved_in ISO
ISS
(PMID:15655246)
GO_REF:0000024
RGD
UniProt
PMID:15655246 GO_REF:0000024 NCBI chr14:17,283,262...17,302,364
Ensembl chr14:17,283,124...17,302,366
JBrowse link
G Plpp1 phospholipid phosphatase 1 involved_in IEA
ISO
IDA
GO_REF:0000107
(MGI:6383560|PMID:10359651)
PMID:8663293
(PMID:9705349)
Ensembl
RGD
PMID:9705349 PMID:10359651, PMID:8663293, PMID:10359651 GO_REF:0000107 MGI:6383560, RGD:15090855, RGD:15090857 NCBI chr 2:44,664,076...44,726,820
Ensembl chr 2:44,664,124...44,726,689
JBrowse link
G Plpp2 phospholipid phosphatase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:9705349)
UniProt
RGD
PMID:9705349 GO_REF:0000024 NCBI chr 7:13,062,168...13,070,281
Ensembl chr 7:13,062,196...13,070,280
JBrowse link
G Plpp3 phospholipid phosphatase 3 involved_in ISO
ISS
(PMID:9305923), (PMID:9705349)
GO_REF:0000024
RGD
UniProt
PMID:9305923 PMID:9705349 GO_REF:0000024 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2176350|PMID:11756451)
RGD PMID:11756451, PMID:21873635 MGI:2176350, RGD:13792537 NCBI chr 6:98,675,324...98,696,492
Ensembl chr 6:98,675,326...98,695,988
JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 involved_in ISO
IBA
(PMID:12411432)
PMID:21873635
RGD PMID:12411432, PMID:21873635 RGD:13792537 NCBI chr 9:84,203,094...84,321,269
Ensembl chr 9:84,203,072...84,319,874
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
ISS
(PMID:20577214)
GO_REF:0000024
RGD
UniProt
PMID:20577214 GO_REF:0000024 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in
acts_upstream_of_or_within
ISO (MGI:3703830|PMID:17346996)
MGI:3580701 (MGI:3608224|PMID:16093248)
RGD PMID:16093248 PMID:17346996 MGI:3608224 MGI:3703830 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
sphingosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of_positive_effect
involved_in
ISO
IEA
(PMID:26510981)
GO_REF:0000107
RGD
Ensembl
PMID:26510981 GO_REF:0000107 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Acer1 alkaline ceramidase 1 involved_in ISO (PMID:17713573), (PMID:20207939), (PMID:20628055)
(MGI:5800647|PMID:27126290), (MGI:6107252|PMID:29056331)
RGD PMID:17713573 PMID:20207939 PMID:20628055 PMID:27126290 PMID:29056331 MGI:5800647 MGI:6107252 NCBI chr 9:10,061,978...10,093,588
Ensembl chr 9:10,061,978...10,093,588
JBrowse link
G Acer2 alkaline ceramidase 2 involved_in ISO (PMID:16940153), (PMID:20089856), (PMID:20207939), (PMID:20628055)
(MGI:6116621|PMID:29401619)
RGD PMID:16940153 PMID:20089856 PMID:20207939 PMID:20628055 PMID:29401619 MGI:6116621 NCBI chr 5:105,230,540...105,279,732
Ensembl chr 5:105,230,580...105,279,731
JBrowse link
G Acer3 alkaline ceramidase 3 involved_in ISO (PMID:20068046), (PMID:20207939), (PMID:26792856)
(MGI:5749603|PMID:26474409)
RGD PMID:20068046 PMID:20207939 PMID:26474409 PMID:26792856 MGI:5749603 NCBI chr 1:163,160,987...163,263,621
Ensembl chr 1:163,160,979...163,263,606
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:1267186|PMID:9653654)
(PMID:10610716), (PMID:12815059)
UniProt
Ensembl
RGD
PMID:9653654 PMID:10610716 PMID:12815059 GO_REF:0000024 GO_REF:0000107 MGI:1267186 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in IDA
ISO
IBA
PMID:15123644
(MGI:3608219|PMID:16126722), (MGI:3640407|PMID:16380386), (MGI:6275120|PMID:10652340)
PMID:15217782
PMID:21873635
(PMID:30154232)
PMID:10488143
RGD PMID:10652340 PMID:16126722 PMID:16380386 PMID:30154232, PMID:15123644, PMID:15217782, PMID:21873635, PMID:10488143 MGI:3608219 MGI:3640407 MGI:6275120, RGD:13838793, RGD:13838794, RGD:13792537, RGD:13838800 NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
JBrowse link
G Gba glucosylceramidase beta involved_in ISO (PMID:19279011) RGD PMID:19279011 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
IEA
IBA
UniProtKB:Q9NRA0 (PMID:23106337)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:23106337, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO
IBA
UniProtKB:Q9NYA1 (PMID:23106337)
PMID:21873635
RGD PMID:23106337, PMID:21873635 RGD:13792537 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3815115 (MGI:3814228|PMID:16216550)
RGD PMID:16216550, PMID:21873635 MGI:3814228, RGD:13792537 NCBI chr17:11,856,525...11,895,566
Ensembl chr17:11,856,525...11,895,566
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3815117 (MGI:3814228|PMID:16216550)
RGD PMID:16216550, PMID:21873635 MGI:3814228, RGD:13792537 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954
JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:132,560,437...132,689,313
Ensembl chr 3:132,560,506...132,692,737
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      nitrogen compound metabolic process 10017
        organonitrogen compound metabolic process 6803
          sphingolipid metabolic process 141
            sphingoid metabolic process 20
              sphingosine metabolic process 18
                sphingosine biosynthetic process 12
                sphingosine catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      organic substance metabolic process 11337
        lipid metabolic process 1362
          cellular lipid metabolic process 1018
            membrane lipid metabolic process 187
              sphingolipid metabolic process 141
                sphingoid metabolic process 20
                  sphingosine metabolic process 18
                    sphingosine biosynthetic process 12
                    sphingosine catabolic process 0
paths to the root