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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of natural killer cell mediated cytotoxicity
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Accession:GO:0045954 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
Synonyms:exact_synonym: positive regulation of NK cell mediated cell death;   positive regulation of NK cell mediated cell killing;   positive regulation of NK cell mediated cytotoxicity;   positive regulation of natural killer cell mediated cell death;   positive regulation of natural killer cell mediated cell killing;   up regulation of natural killer cell mediated cytotoxicity;   upregulation of natural killer cell mediated cytotoxicity
 narrow_synonym: activation of natural killer cell mediated cytotoxicity;   stimulation of natural killer cell mediated cytotoxicity
 related_synonym: positive regulation of NK cell mediated cytolysis;   positive regulation of natural killer cell mediated cytolysis


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positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1G1 adaptor related protein complex 1 subunit gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:14,719,949...14,809,821
Ensembl chr 6:14,719,959...14,809,491 		JBrowse link
G BID BH3 interacting domain death agonist ISO RGD PMID:17893612 RGD:408346749 NCBI chr 5:69,849,007...69,874,647
Ensembl chr 5:69,849,002...69,875,853 		JBrowse link
G CADM1 cell adhesion molecule 1 involved_in ISO (PMID:15811952) UniProt PMID:15811952 NCBI chr 9:42,644,487...42,984,934
Ensembl chr 9:42,644,429...42,985,017 		JBrowse link
G CD160 CD160 molecule involved_in ISO (PMID:12486241), (PMID:17307798) UniProt PMID:12486241 PMID:17307798 NCBI chr 4:99,579,891...99,585,808 JBrowse link
G CD226 CD226 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:152,872,878...152,977,162
Ensembl chr 1:152,882,762...152,979,845 		JBrowse link
G CRTAM cytotoxic and regulatory T cell molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:49,782,166...49,811,314
Ensembl chr 9:49,783,909...49,811,312 		JBrowse link
G GIMAP5 GTPase, IMAP family member 5 ISO RGD PMID:15100275 RGD:2303778 NCBI chr18:6,363,443...6,371,725 JBrowse link
G IL12A interleukin 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:99,733,394...99,741,078
Ensembl chr13:99,733,394...99,741,078 		JBrowse link
G IL18RAP interleukin 18 receptor accessory protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15843532) Ensembl
MGI		 PMID:15843532 GO_REF:0000107 NCBI chr 3:51,762,111...51,794,552
Ensembl chr 3:51,762,486...51,794,471 		JBrowse link
G IL21 interleukin 21 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:14764669) Ensembl
MGI
GO_Central		 PMID:14764669 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,532,531...101,541,713 		JBrowse link
G KLRD1 killer cell lectin like receptor D1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:61,662,083...61,673,109
Ensembl chr 5:61,666,654...61,673,129 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 involved_in
acts_upstream_of_or_within		 IEA
ISS
IBA
ISO		 (PMID:12645935) InterPro
UniProt
Ensembl
GO_Central
MGI		 PMID:12645935 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:61,646,691...61,655,386
Ensembl chr 5:61,647,043...61,656,192 		JBrowse link
G LAG3 lymphocyte activating 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8602528) Ensembl
MGI		 PMID:8602528 GO_REF:0000107 NCBI chr 5:63,929,669...63,935,054
Ensembl chr 5:63,929,625...63,935,410 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:78,600,818...78,617,587
Ensembl chr11:78,600,713...78,617,615 		JBrowse link
G LOC100519314 natural killer cells antigen CD94 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:61,724,744...61,736,667 JBrowse link
G LOC100521998 NKG2D ligand 4-like involved_in ISO (PMID:18544572) UniProt PMID:18544572 NCBI chr 1:16,057,036...16,059,787 JBrowse link
G LOC100523789 NKG2-A/NKG2-B type II integral membrane protein involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:61,621,869...61,633,693 JBrowse link
G NCR3 natural cytotoxicity triggering receptor 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr 7:23,713,333...23,716,988 JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in ISO (PMID:16304049) BHF-UCL PMID:16304049 NCBI chr 6:51,317,386...51,358,665 JBrowse link
G PVR PVR cell adhesion molecule involved_in ISO (PMID:16304049) BHF-UCL PMID:16304049 NCBI chr 6:51,161,320...51,178,464 JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:132,702,495...132,786,536
Ensembl chr 1:132,702,541...132,786,532 		JBrowse link
G SH2D1A SH2 domain containing 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19648922)
(PMID:16127454)		 Ensembl
MGI		 PMID:16127454 PMID:19648922 GO_REF:0000107 NCBI chr  X:101,824,602...101,847,265
Ensembl chr  X:101,824,367...101,849,671 		JBrowse link
G SH2D1B SH2 domain containing 1B acts_upstream_of_or_within ISO (PMID:19648922)
(PMID:20962259)		 MGI PMID:19648922 PMID:20962259 NCBI chr 4:88,097,534...88,129,792 JBrowse link
G SLA-8 MHC class I antigen 8 acts_upstream_of_or_within ISO (PMID:16476767) MGI PMID:16476767 NCBI chr 7:23,622,352...23,625,818 JBrowse link
G SLAMF6 SLAM family member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:89,980,592...90,004,222
Ensembl chr 4:89,980,786...90,003,645 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO (PMID:9841920) MGI PMID:9841920 NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9841920) Ensembl
MGI		 PMID:9841920 GO_REF:0000107 NCBI chr12:20,498,103...20,574,365
Ensembl chr12:20,508,404...20,574,266 		JBrowse link
G VAV1 vav guanine nucleotide exchange factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20962259) Ensembl
MGI		 PMID:20962259 GO_REF:0000107 NCBI chr 2:72,327,433...72,391,649
Ensembl chr 2:72,326,716...72,391,648 		JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1G1 adaptor related protein complex 1 subunit gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:14,719,949...14,809,821
Ensembl chr 6:14,719,959...14,809,491 		JBrowse link
G CD160 CD160 molecule involved_in ISO (PMID:19109136) UniProt PMID:19109136 NCBI chr 4:99,579,891...99,585,808 JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:78,600,818...78,617,587
Ensembl chr11:78,600,713...78,617,615 		JBrowse link
G SLA-7 MHC class I antigen 7 involved_in ISO (PMID:27455421) UniProt PMID:27455421 NCBI chr 7:23,634,731...23,638,722 JBrowse link
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD226 CD226 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:152,872,878...152,977,162
Ensembl chr 1:152,882,762...152,979,845 		JBrowse link
G CRTAM cytotoxic and regulatory T cell molecule involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:49,782,166...49,811,314
Ensembl chr 9:49,783,909...49,811,312 		JBrowse link
G IL12A interleukin 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:99,733,394...99,741,078
Ensembl chr13:99,733,394...99,741,078 		JBrowse link
G IL12B interleukin 12B involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 ISO RGD PMID:16323246 RGD:9685180 NCBI chr 5:61,646,691...61,655,386
Ensembl chr 5:61,647,043...61,656,192 		JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:51,317,386...51,358,665 JBrowse link
G PVR PVR cell adhesion molecule involved_in ISO (PMID:12913096) BHF-UCL PMID:12913096 NCBI chr 6:51,161,320...51,178,464 JBrowse link
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADM1 cell adhesion molecule 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:42,644,487...42,984,934
Ensembl chr 9:42,644,429...42,985,017 		JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in ISO (PMID:12913096) BHF-UCL PMID:12913096 NCBI chr 6:51,317,386...51,358,665 JBrowse link
G PVR PVR cell adhesion molecule involved_in ISO (PMID:12913096) BHF-UCL PMID:12913096 NCBI chr 6:51,161,320...51,178,464 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17668
    cellular process 17206
      positive regulation of cellular process 6124
        positive regulation of cell killing 61
          positive regulation of leukocyte mediated cytotoxicity 56
            positive regulation of natural killer cell mediated cytotoxicity 30
              positive regulation of natural killer cell degranulation 4
              positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 7
              susceptibility to natural killer cell mediated cytotoxicity 3
Path 2
Term Annotations click to browse term
  biological_process 17668
    response to stimulus 10007
      response to external stimulus 2557
        response to external biotic stimulus 1689
          response to other organism 1685
            defense response to other organism 1163
              defense response to symbiont 954
                innate immune response 879
                  natural killer cell mediated immunity 79
                    regulation of natural killer cell mediated immunity 56
                      positive regulation of natural killer cell mediated immunity 33
                        positive regulation of natural killer cell mediated cytotoxicity 30
                          positive regulation of natural killer cell degranulation 4
                          positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target 7
                          susceptibility to natural killer cell mediated cytotoxicity 3
paths to the root