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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043370 term browser browse the term
Definition:Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: regulation of CD4-positive T lymphocyte differentiation;   regulation of CD4-positive T-cell differentiation;   regulation of CD4-positive, alpha beta T lymphocyte differentiation
 related_synonym: regulation of CD4-positive, alpha beta T cell development

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regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sh3rf1 SH3 domain containing ring finger 1 involved_in ISO (MGI:6158776|PMID:27084103) UniProt PMID:27084103 MGI:6158776 NCBI chrNW_004624769:668,175...834,863
Ensembl chrNW_004624769:666,406...834,156 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chrNW_004624746:19,204,415...19,264,217
Ensembl chrNW_004624746:19,204,392...19,264,194 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:22473704) UniProt PMID:22473704 NCBI chrNW_004624776:7,858,400...7,862,716
Ensembl chrNW_004624776:7,793,259...7,863,184 		JBrowse link
G Runx3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chrNW_004624764:9,192,067...9,218,617
Ensembl chrNW_004624764:9,191,556...9,248,252 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) UniProt PMID:24463518 MGI:5565031 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chrNW_004624908:1,371,595...1,383,879
Ensembl chrNW_004624908:1,371,595...1,383,879 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) UniProt PMID:24463518 MGI:5565031 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) UniProt PMID:23169781 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Il2 interleukin 2 involved_in ISO (MGI:5634593|PMID:25642768) BHF-UCL PMID:25642768 MGI:5634593 NCBI chrNW_004624777:2,885,537...2,890,453
Ensembl chrNW_004624777:2,885,535...2,890,453 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) MGI PMID:18792410 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624760:12,025,206...12,074,548 JBrowse link
G Smad7 SMAD family member 7 involved_in ISO (MGI:5634593|PMID:25642768) BHF-UCL PMID:25642768 MGI:5634593 NCBI chrNW_004624778:12,415,364...12,444,882
Ensembl chrNW_004624778:12,415,282...12,444,835 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) UniProt PMID:21151104 MGI:4868293 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO (PMID:23034280) MGI PMID:23034280 NCBI chrNW_004624885:2,474,427...2,489,024
Ensembl chrNW_004624885:2,475,727...2,489,030 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:20,224,919...20,234,108
Ensembl chrNW_004624764:20,224,906...20,234,629 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 CD69 molecule involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004624860:4,345,497...4,364,251
Ensembl chrNW_004624860:4,345,232...4,365,817 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) UniProt PMID:20696842 NCBI chrNW_004624908:1,371,595...1,383,879
Ensembl chrNW_004624908:1,371,595...1,383,879 		JBrowse link
G Lgals1 galectin 1 involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004624752:10,220,115...10,223,434
Ensembl chrNW_004624752:10,219,872...10,223,317 		JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624749:28,959,682...28,980,428
Ensembl chrNW_004624749:28,960,593...28,980,428 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) UniProt PMID:21151104 MGI:4868293 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chrNW_004624771:8,711,093...8,722,518
Ensembl chrNW_004624771:8,711,017...8,722,539 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624811:765,338...782,203
Ensembl chrNW_004624811:764,940...782,198 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) UniProt PMID:24463518 MGI:5565031 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004624730:69,145,035...69,167,583
Ensembl chrNW_004624730:69,154,080...69,167,689 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624835:4,223,252...4,227,892
Ensembl chrNW_004624835:4,223,511...4,227,979 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) UniProt PMID:12242343 MGI:3687909 NCBI chrNW_004624738:28,150,004...28,217,850
Ensembl chrNW_004624738:28,150,664...28,216,389 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO (PMID:15917799) MGI PMID:15917799 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd83 CD83 molecule acts_upstream_of_or_within ISO (PMID:15322158) MGI PMID:15322158 NCBI chrNW_004624756:12,212,921...12,229,974
Ensembl chrNW_004624756:12,210,892...12,229,749 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:17028180) MGI PMID:17028180 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624904:2,508,576...2,575,505
Ensembl chrNW_004624904:2,508,799...2,578,609 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16227612) MGI
Ensembl		 PMID:16227612 GO_REF:0000107 NCBI chrNW_004624797:9,001,846...9,017,441
Ensembl chrNW_004624797:9,001,795...9,018,027 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in ISO (MGI:6140589|PMID:24880459) UniProt PMID:24880459 MGI:6140589 NCBI chrNW_004624824:8,444,877...8,446,628 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4819294|PMID:20639485) BHF-UCL PMID:20639485 MGI:4819294 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6140589|PMID:24880459) UniProt PMID:24880459 MGI:6140589 NCBI chrNW_004624885:2,474,427...2,489,024
Ensembl chrNW_004624885:2,475,727...2,489,030 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16301745), (PMID:18573908)
(PMID:16275384)
(PMID:12612578)		 MGI PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO (PMID:16227984) MGI PMID:16227984 NCBI chrNW_004624903:1,402,586...1,406,554
Ensembl chrNW_004624903:1,402,481...1,406,600 		JBrowse link
G Klhl25 kelch like family member 25 involved_in ISO (MGI:6765767|PMID:34491895)
(PMID:34491895)		 UniProt PMID:34491895 MGI:6765767 NCBI chrNW_004624768:13,112,589...13,134,855
Ensembl chrNW_004624768:13,110,912...13,121,206 		JBrowse link
G LOC101706353 HLA class II histocompatibility antigen, DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624754:24,079,459...24,086,342
Ensembl chrNW_004624754:24,079,366...24,084,512 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chrNW_004624786:478,048...491,086 JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624811:765,338...782,203
Ensembl chrNW_004624811:764,940...782,198 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chrNW_004624736:39,088,741...39,090,745
Ensembl chrNW_004624736:39,088,921...39,090,394 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624835:4,223,252...4,227,892
Ensembl chrNW_004624835:4,223,511...4,227,979 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within ISO (PMID:11894097) MGI PMID:11894097 NCBI chrNW_004624744:2,194,339...2,227,498
Ensembl chrNW_004624744:2,201,319...2,226,890 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) UniProt PMID:12242343 MGI:3687909 NCBI chrNW_004624738:28,150,004...28,217,850
Ensembl chrNW_004624738:28,150,664...28,216,389 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624792:4,148,258...4,223,431
Ensembl chrNW_004624792:4,148,453...4,217,548 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624794:10,172,789...10,180,693
Ensembl chrNW_004624794:10,168,792...10,179,510 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) UniProt PMID:26098997 MGI:5689221 NCBI chrNW_004624937:564,191...584,470 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISO (MGI:6106706|PMID:28262505)
(PMID:28262505)		 UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004624754:23,742,506...23,750,668
Ensembl chrNW_004624754:23,742,509...23,750,062 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (MGI:6106706|PMID:28262505) UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004624901:2,348,218...2,434,429
Ensembl chrNW_004624901:2,346,734...2,380,852 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624802:11,662,851...11,664,444
Ensembl chrNW_004624802:11,662,753...11,665,418 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) UniProt PMID:26098997 MGI:5689221 NCBI chrNW_004624937:564,191...584,470 JBrowse link
G Prkcz protein kinase C zeta involved_in ISO (MGI:3584076|PMID:15987782) UniProt PMID:15987782 MGI:3584076 NCBI chrNW_004624818:7,758,192...7,846,950
Ensembl chrNW_004624818:7,759,770...7,847,208 		JBrowse link
G Rara retinoic acid receptor alpha involved_in ISO (PMID:18416830) BHF-UCL PMID:18416830 NCBI chrNW_004624795:2,935,432...2,975,226
Ensembl chrNW_004624795:2,934,731...2,967,232 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4943387|PMID:18354165) BHF-UCL PMID:18354165 MGI:4943387 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO (PMID:24645804) MGI PMID:24645804 NCBI chrNW_004624825:3,846,604...3,972,780
Ensembl chrNW_004624825:3,845,092...3,973,636 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624782:13,009,450...13,015,548
Ensembl chrNW_004624782:13,009,564...13,015,440 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chrNW_004624843:2,017,738...2,021,153 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (MGI:3820359|PMID:19050256) UniProt PMID:19050256 MGI:3820359 NCBI chrNW_004624785:12,190,802...12,203,924 JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18776904) Ensembl
MGI		 PMID:18776904 GO_REF:0000107 NCBI chrNW_004624775:2,985,077...3,014,567
Ensembl chrNW_004624775:2,994,164...3,015,392 		JBrowse link
G LOC101706353 HLA class II histocompatibility antigen, DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624754:24,079,459...24,086,342
Ensembl chrNW_004624754:24,079,366...24,084,512 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO (PMID:18776904) MGI PMID:18776904 NCBI chrNW_004624885:2,474,427...2,489,024
Ensembl chrNW_004624885:2,475,727...2,489,030 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15052
    immune system process 2108
      leukocyte activation 899
        lymphocyte activation 731
          T cell activation 511
            alpha-beta T cell activation 177
              CD4-positive, alpha-beta T cell activation 118
                CD4-positive, alpha-beta T cell differentiation 92
                  regulation of CD4-positive, alpha-beta T cell differentiation 52
                    negative regulation of CD4-positive, alpha-beta T cell differentiation + 24
                    positive regulation of CD4-positive, alpha-beta T cell differentiation + 30
                    regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
                    regulation of T-helper cell differentiation + 40
Path 2
Term Annotations click to browse term
  biological_process 15052
    developmental process 6157
      cellular developmental process 4126
        cell differentiation 4125
          cell development 2965
            hemopoiesis 930
              leukocyte differentiation 596
                mononuclear cell differentiation 483
                  lymphocyte differentiation 394
                    T cell differentiation 293
                      alpha-beta T cell differentiation 129
                        CD4-positive, alpha-beta T cell differentiation 92
                          regulation of CD4-positive, alpha-beta T cell differentiation 52
                            negative regulation of CD4-positive, alpha-beta T cell differentiation + 24
                            positive regulation of CD4-positive, alpha-beta T cell differentiation + 30
                            regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
                            regulation of T-helper cell differentiation + 40
paths to the root