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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid metabolic process
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Accession:GO:0042573 term browser browse the term
Definition:The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid metabolism;   vitamin A1 acid metabolic process;   vitamin A1 acid metabolism


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retinoic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:91,726,870...91,741,824
Ensembl chr 4:102,388,575...102,435,079 		JBrowse link
G ADH6 alcohol dehydrogenase 6 (class V) involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:91,604,422...91,621,342
Ensembl chr 4:102,264,224...102,283,210 		JBrowse link
G ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10358022), (PMID:10402668) Ensembl
TreeGrafter
MGI		 PMID:10358022 PMID:10402668 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:91,833,111...91,856,325
Ensembl chr 4:102,494,784...102,518,215 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 acts_upstream_of_or_within ISO (PMID:16207763)
(PMID:12808103), (PMID:12851412)
(PMID:10191271)		 MGI PMID:10191271 PMID:12808103 PMID:12851412 PMID:16207763 NCBI chr 9:51,737,305...51,916,648
Ensembl chr 9:71,680,890...71,814,085 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14623241)
(PMID:8797830)
(PMID:16368932)		 RGD
MGI
Ensembl		 PMID:8797830 PMID:12547725 PMID:14623241 PMID:16368932 GO_REF:0000107 RGD:1576367 NCBI chr15:36,925,443...37,038,288
Ensembl chr15:55,237,101...55,557,168 		JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16207763)
(PMID:17207476)		 Ensembl
MGI		 PMID:16207763 PMID:17207476 GO_REF:0000107 NCBI chr15:79,603,893...79,640,866
Ensembl chr15:98,891,770...98,928,396 		JBrowse link
G ALDH8A1 aldehyde dehydrogenase 8 family member A1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:132,685,904...132,732,194
Ensembl chr 6:136,782,957...136,815,611 		JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9826179) Ensembl
MGI		 PMID:9826179 GO_REF:0000107 NCBI chr 1:132,043,097...132,049,366
Ensembl chr 1:135,864,807...135,870,145 		JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15531370) Ensembl
MGI		 PMID:15531370 GO_REF:0000107 NCBI chr10:89,817,623...89,822,024
Ensembl chr10:93,330,460...93,334,105 		JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:72,172,658...72,191,410
Ensembl chr2A:73,670,830...73,686,433 		JBrowse link
G CYP27C1 cytochrome P450 family 27 subfamily C member 1 involved_in ISO (PMID:27059013) UniProt PMID:27059013 NCBI chr2B:33,057,718...33,092,809
Ensembl chr2B:127,859,318...127,872,150 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 involved_in ISO (PMID:11093772) UniProt PMID:11093772 NCBI chr10:91,646,387...91,679,998
Ensembl chr10:95,157,661...95,186,620 		JBrowse link
G CYP2S1 cytochrome P450 family 2 subfamily S member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:38,185,893...38,200,064
Ensembl chr19:46,693,025...46,705,950 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:91,797,037...91,824,696
Ensembl chr 7:105,230,666...105,258,401 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:91,621,561...91,654,164
Ensembl chr 7:105,123,437...105,155,322 		JBrowse link
G CYP3A67 cytochrome P450 family 3 subfamily A member 67 involved_in ISO (PMID:11093772) UniProt PMID:11093772 NCBI chr 7:91,678,209...91,707,321
Ensembl chr 7:105,160,420...105,208,799 		JBrowse link
G LOC100970753 alcohol dehydrogenase 1C acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15193143)
(PMID:10358022), (PMID:12851412)		 MGI
TreeGrafter		 PMID:10358022 PMID:12851412 PMID:15193143 GO_REF:0000118 NCBI chr 4:91,756,817...91,773,056
Ensembl chr 4:102,388,575...102,435,079 		JBrowse link
G LOC100971436 alcohol dehydrogenase 1A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:91,697,663...91,712,314
Ensembl chr 4:102,359,419...102,374,101 		JBrowse link
G RBP1 retinol binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15193143) Ensembl
MGI		 PMID:15193143 GO_REF:0000107 NCBI chr 3:136,554,315...136,576,682
Ensembl chr 3:144,153,937...144,176,209 		JBrowse link
G RDH16 retinol dehydrogenase 16 ISO RGD PMID:7499345 RGD:1299624 NCBI chr12:31,958,385...31,966,319
Ensembl chr12:32,212,746...32,219,624 		JBrowse link
G SCPEP1 serine carboxypeptidase 1 ISO RGD PMID:11447226 RGD:70518 NCBI chr17:51,055,293...51,084,032
Ensembl chr17:55,915,746...55,944,377 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chr 9:51,737,305...51,916,648
Ensembl chr 9:71,680,890...71,814,085 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr15:36,925,443...37,038,288
Ensembl chr15:55,237,101...55,557,168 		JBrowse link
G ALDH8A1 aldehyde dehydrogenase 8 family member A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr 6:132,685,904...132,732,194
Ensembl chr 6:136,782,957...136,815,611 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:56,347,489...56,376,463
Ensembl chr2B:173,811,932...173,842,816 		JBrowse link
G RDH16 retinol dehydrogenase 16 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chr12:31,958,385...31,966,319
Ensembl chr12:32,212,746...32,219,624 		JBrowse link
9-cis-retinoic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO RGD PMID:17167544 RGD:2306320 NCBI chr 9:51,737,305...51,916,648
Ensembl chr 9:71,680,890...71,814,085 		JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1 member C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:5,079,580...5,157,572
Ensembl chr10:5,081,214...5,139,812 		JBrowse link
G PRMT3 protein arginine methyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:20,412,419...20,538,295
Ensembl chr11:20,324,196...20,449,681 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RDH10 retinol dehydrogenase 10 ISO RGD PMID:21138835 RGD:6771354 NCBI chr 8:69,833,320...69,863,536
Ensembl chr 8:71,481,089...71,510,689 		JBrowse link
G RDH16 retinol dehydrogenase 16 ISO RGD PMID:21138835 RGD:6771354 NCBI chr12:31,958,385...31,966,319
Ensembl chr12:32,212,746...32,219,624 		JBrowse link
retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO RGD PMID:21138835 RGD:6771354 NCBI chr 9:51,737,305...51,916,648
Ensembl chr 9:71,680,890...71,814,085 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15950969 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr15:36,925,443...37,038,288
Ensembl chr15:55,237,101...55,557,168 		JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11013254), (PMID:11044606), (PMID:16241904) RGD
MGI
Ensembl		 PMID:11013254 PMID:11044606 PMID:15950969 PMID:16241904 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr15:79,603,893...79,640,866
Ensembl chr15:98,891,770...98,928,396 		JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 ISO RGD PMID:15950969 RGD:6771322 NCBI chr 1:132,043,097...132,049,366
Ensembl chr 1:135,864,807...135,870,145 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 ISO RGD PMID:15950969 PMID:21138835 RGD:6771322 RGD:6771354 NCBI chr2B:56,347,489...56,376,463
Ensembl chr2B:173,811,932...173,842,816 		JBrowse link
G RBP1 retinol binding protein 1 involved_in ISO
IEA		 RGD
InterPro		 PMID:15950969 GO_REF:0000002 RGD:6771322 NCBI chr 3:136,554,315...136,576,682
Ensembl chr 3:144,153,937...144,176,209 		JBrowse link
G RDH10 retinol dehydrogenase 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17473173) Ensembl
MGI		 PMID:17473173 GO_REF:0000107 NCBI chr 8:69,833,320...69,863,536
Ensembl chr 8:71,481,089...71,510,689 		JBrowse link
retinoic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:89,817,623...89,822,024
Ensembl chr10:93,330,460...93,334,105 		JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:21138835 GO_REF:0000107 RGD:6771354 NCBI chr2A:72,172,658...72,191,410
Ensembl chr2A:73,670,830...73,686,433 		JBrowse link
G CYP26C1 cytochrome P450 family 26 subfamily C member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:89,804,830...89,813,687
Ensembl chr10:93,317,798...93,325,315 		JBrowse link
G CYP2W1 cytochrome P450 family 2 subfamily W member 1 involved_in ISO (PMID:26936974) UniProt PMID:26936974 NCBI chr 7:1,140,855...1,147,788
Ensembl chr 7:1,353,510...1,362,781 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16644
    cellular process 16207
      metabolic process 10770
        hormone metabolic process 237
          retinoic acid metabolic process 28
            9-cis-retinoic acid metabolic process + 6
            retinoic acid biosynthetic process + 12
            retinoic acid catabolic process 4
            retinoic acid metabolic process in spinal cord anterior-posterior patterning 0
Path 2
Term Annotations click to browse term
  biological_process 16644
    cellular process 16207
      metabolic process 10770
        primary metabolic process 9466
          lipid metabolic process 1311
            isoprenoid metabolic process 114
              terpenoid metabolic process 91
                diterpenoid metabolic process 81
                  retinoid metabolic process 73
                    retinoic acid metabolic process 28
                      9-cis-retinoic acid metabolic process + 6
                      retinoic acid biosynthetic process + 12
                      retinoic acid catabolic process 4
                      retinoic acid metabolic process in spinal cord anterior-posterior patterning 0
paths to the root