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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartic endopeptidase activity, intramembrane cleaving
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Accession:GO:0042500 term browser browse the term
Definition:Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.
Comment:Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
Synonyms:xref: EC:3.4.23;   Reactome:R-HSA-9708457 "HM13 cleaves HMOX1 dimer";   reactome:R-HSA-8863101 "SPPL2a/b cleaves TNF(1-76)"


show annotations for term's descendants           Sort by:
aspartic endopeptidase activity, intramembrane cleaving term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 enables ISO
IBA		 (PMID:16873890), (PMID:25239945)
GO_REF:0000033		 RGD
GO_Central		 PMID:16873890 PMID:25239945 GO_REF:0000033 NCBI chr 3:141,145,792...141,183,557
Ensembl chr 3:141,145,782...141,184,703 		JBrowse link
G Ncstn nicastrin contributes_to ISO MGI:1202717|MGI:3522097 (PMID:16371134) RGD PMID:16371134 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psen1 presenilin 1 enables
contributes_to		 ISS
ISO
IBA		 GO_REF:0000024
(PMID:17428795), (PMID:26280335)
GO_REF:0000033
MGI:1891700|MGI:3522097 (PMID:16371134)
MGI:109284 (PMID:21206757)		 UniProt
RGD
GO_Central		 PMID:16371134 PMID:17428795 PMID:21206757 PMID:26280335 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 enables IBA
ISO		 GO_REF:0000033
MGI:1202717|MGI:1930939 (PMID:12684521), (PMID:21206757)		 GO_Central
RGD		 PMID:12684521 PMID:21206757 GO_REF:0000033 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Sppl2a signal peptide peptidase-like 2A enables ISO
IBA		 (PMID:2313285)
GO_REF:0000033		 RGD
GO_Central		 PMID:2313285 GO_REF:0000033 NCBI chr 3:114,149,337...114,193,408
Ensembl chr 3:114,151,069...114,193,264 		JBrowse link
G Sppl2b signal peptide peptidase-like 2B NOT|enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:16873890)
(PMID:19114711), (PMID:22194595), (PMID:2313285)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033		 UniProt
RGD
Ensembl
InterPro
GO_Central		 PMID:2313285 PMID:16873890 PMID:19114711 PMID:22194595 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:8,843,918...8,856,642
Ensembl chr 7:8,843,918...8,856,608 		JBrowse link
G Sppl2c signal peptide peptidase like 2C enables ISO
IBA		 (MGI:6281843|PMID:30733280), (MGI:7332329|PMID:35960805), (MGI:7387163|PMID:30733281)
GO_REF:0000033		 RGD
GO_Central		 PMID:30733280 PMID:30733281 PMID:35960805 GO_REF:0000033 MGI:6281843 MGI:7332329 MGI:7387163 NCBI chr10:89,095,279...89,097,487
Ensembl chr10:89,095,261...89,098,580 		JBrowse link
G Sppl3 signal peptide peptidase like 3 enables ISO
IBA		 (PMID:16873890), (PMID:2313285)
GO_REF:0000033		 RGD
GO_Central		 PMID:2313285 PMID:16873890 GO_REF:0000033 NCBI chr12:41,515,635...41,600,079
Ensembl chr12:41,515,640...41,600,126 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    catalytic activity 6036
      hydrolase activity 2592
        peptidase activity 689
          endopeptidase activity 458
            aspartic-type endopeptidase activity 30
              aspartic endopeptidase activity, intramembrane cleaving 8
paths to the root