Gene: Sppl2b (signal peptide peptidase-like 2B) Rattus norvegicus
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Symbol: Sppl2b
Name: signal peptide peptidase-like 2B
Description: ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN membrane protein ectodomain proteolysis (ortholog); membrane protein intracellular domain proteolysis (ortholog); membrane protein proteolysis (ortholog); FOUND IN actin cytoskeleton (ortholog); centrosome (ortholog); endosome membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; vinclozolin
AGR Description: Predicted to have aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity; predicted to be involved in membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, and regulation of immune response; predicted to localize to the intracellular organelle and plasma membrane; orthologous to human SPPL2B (signal peptide peptidase like 2B).
Merged Description: Predicted to have aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity; predicted to be involved in membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, and regulation of immune response; predicted to localize to the intracellular organelle and plasma membrane; orthologous to human SPPL2B (signal peptide peptidase like 2B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC362828; presenilin-like protein 1; RGD1308556; similar to SPPL2b; SPP-like 2B
Orthologs:
Homo sapiens (human) : SPPL2B (signal peptide peptidase like 2B)  HGNC  Alliance
Mus musculus (house mouse) : Sppl2b (signal peptide peptidase like 2B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sppl2b (signal peptide peptidase like 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : SPPL2B (signal peptide peptidase like 2B)
Canis lupus familiaris (dog) : SPPL2B (signal peptide peptidase like 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sppl2b (signal peptide peptidase like 2B)
Sus scrofa (pig) : SPPL2B (signal peptide peptidase like 2B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0711,712,187 - 11,724,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0711,879,707 - 11,892,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,354,554 - 10,367,210 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,354,554 - 10,367,210 (-)NCBI
Celera77,028,038 - 7,040,694 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Sppl2b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308556
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.