Sppl2b (signal peptide peptidase-like 2B) - Rat Genome Database

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Gene: Sppl2b (signal peptide peptidase-like 2B) Rattus norvegicus
Analyze
Symbol: Sppl2b
Name: signal peptide peptidase-like 2B
RGD ID: 1308556
Description: Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in several cellular components, including cytoskeleton; endosome membrane; and nucleoplasm. Predicted to be active in Golgi-associated vesicle membrane and lysosomal membrane. Predicted to be integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. Orthologous to human SPPL2B (signal peptide peptidase like 2B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chlormequat chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362828; presenilin-like protein 1; RGD1308556; similar to SPPL2b; SPP-like 2B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,843,918 - 8,856,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,843,918 - 8,856,608 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,727,769 - 11,740,555 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,603,273 - 13,616,059 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,469,804 - 11,482,591 (-)NCBIRnor_WKY
Rnor_6.0711,712,187 - 11,724,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,712,188 - 11,724,843 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,879,707 - 11,892,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,354,554 - 10,367,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,354,554 - 10,367,210 (-)NCBI
Celera77,028,038 - 7,040,694 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2313285   PMID:15385547   PMID:15489334   PMID:15998642   PMID:16829951   PMID:16829952   PMID:16873890   PMID:17965014   PMID:19114711   PMID:21896273   PMID:22194595  


Genomics

Comparative Map Data
Sppl2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,843,918 - 8,856,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,843,918 - 8,856,608 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,727,769 - 11,740,555 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,603,273 - 13,616,059 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,469,804 - 11,482,591 (-)NCBIRnor_WKY
Rnor_6.0711,712,187 - 11,724,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,712,188 - 11,724,843 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,879,707 - 11,892,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,354,554 - 10,367,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,354,554 - 10,367,210 (-)NCBI
Celera77,028,038 - 7,040,694 (-)NCBICelera
Cytogenetic Map7q11NCBI
SPPL2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,328,684 - 2,355,095 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl192,328,615 - 2,355,095 (+)EnsemblGRCh38hg38GRCh38
GRCh37192,328,683 - 2,355,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,279,629 - 2,306,100 (+)NCBINCBI36Build 36hg18NCBI36
Celera192,262,722 - 2,289,416 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,099,320 - 2,126,087 (+)NCBIHuRef
CHM1_1192,328,242 - 2,354,745 (+)NCBICHM1_1
T2T-CHM13v2.0192,302,357 - 2,328,755 (+)NCBIT2T-CHM13v2.0
Sppl2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,691,067 - 80,704,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,691,109 - 80,704,542 (+)EnsemblGRCm39 Ensembl
GRCm381080,855,242 - 80,868,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,855,275 - 80,868,708 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,318,020 - 80,331,453 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,258,386 - 80,271,834 (+)NCBIMGSCv36mm8
Celera1081,874,073 - 81,887,506 (+)NCBICelera
Cytogenetic Map10C1NCBI
Sppl2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,818,337 - 5,829,889 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,816,979 - 5,829,938 (-)NCBIChiLan1.0ChiLan1.0
SPPL2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1192,309,360 - 2,331,951 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,309,360 - 2,331,951 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0191,337,570 - 1,355,755 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SPPL2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,714,306 - 56,730,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,712,390 - 56,757,938 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,509,908 - 56,525,995 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,447,711 - 57,463,802 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,447,720 - 57,463,752 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,499,796 - 56,515,881 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,985,051 - 57,001,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,185,354 - 57,201,441 (-)NCBIUU_Cfam_GSD_1.0
Sppl2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,426,113 - 216,435,356 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365881,399,125 - 1,408,676 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPPL2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,230,061 - 76,247,051 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,230,060 - 76,247,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,781,961 - 76,798,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPPL2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,121,568 - 2,142,746 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,121,634 - 2,144,682 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,566,507 - 6,588,105 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sppl2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,562,426 - 6,576,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,564,127 - 6,576,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH134584  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,844,009 - 8,844,191 (+)MAPPERmRatBN7.2
Rnor_6.0711,712,279 - 11,712,460NCBIRnor6.0
Rnor_5.0711,879,799 - 11,879,980UniSTSRnor5.0
RGSC_v3.4710,354,646 - 10,354,827UniSTSRGSC3.4
Celera77,028,130 - 7,028,311UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:150
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000043162
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 45 33 19 33 1 4 74 33 41 11 1
Low 9 12 8 8 7 7 2 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001014200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_593258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC103000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000084144   ⟹   ENSRNOP00000074120
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,843,918 - 8,856,608 (-)Ensembl
Rnor_6.0 Ensembl711,712,188 - 11,724,843 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097476   ⟹   ENSRNOP00000089491
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,843,920 - 8,856,586 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100592   ⟹   ENSRNOP00000087622
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,844,616 - 8,856,591 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109298   ⟹   ENSRNOP00000081849
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,843,918 - 8,851,660 (-)Ensembl
RefSeq Acc Id: NM_001014200   ⟹   NP_001014222
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,574 (-)NCBI
Rnor_6.0711,712,187 - 11,724,843 (-)NCBI
Rnor_5.0711,879,707 - 11,892,620 (-)NCBI
RGSC_v3.4710,354,554 - 10,367,210 (-)RGD
Celera77,028,038 - 7,040,694 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240947   ⟹   XP_006241009
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,912 (-)NCBI
Rnor_5.0711,879,707 - 11,892,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240948   ⟹   XP_006241010
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,911 (-)NCBI
Rnor_5.0711,879,707 - 11,892,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765110   ⟹   XP_008763332
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,915 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765111   ⟹   XP_008763333
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,914 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765112   ⟹   XP_008763334
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,914 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765116   ⟹   XP_008763338
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,713,415 - 11,724,914 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594908   ⟹   XP_017450397
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
Rnor_6.0711,712,187 - 11,724,915 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079384   ⟹   XP_038935312
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
RefSeq Acc Id: XM_039079385   ⟹   XP_038935313
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,845,093 - 8,856,642 (-)NCBI
RefSeq Acc Id: XM_039079386   ⟹   XP_038935314
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
RefSeq Acc Id: XM_039079387   ⟹   XP_038935315
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,620 (-)NCBI
RefSeq Acc Id: XM_039079388   ⟹   XP_038935316
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,847,964 (-)NCBI
RefSeq Acc Id: XM_039079389   ⟹   XP_038935317
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,847,791 - 8,856,642 (-)NCBI
RefSeq Acc Id: XR_005486655
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,846,096 - 8,856,642 (-)NCBI
RefSeq Acc Id: XR_005486656
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,843,918 - 8,856,642 (-)NCBI
RefSeq Acc Id: XR_593258
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,845,094 - 8,856,642 (-)NCBI
Rnor_6.0711,713,419 - 11,724,914 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001014222   ⟸   NM_001014200
- Peptide Label: precursor
- UniProtKB: Q5PQL3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006241010   ⟸   XM_006240948
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006241009   ⟸   XM_006240947
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008763334   ⟸   XM_008765112
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008763333   ⟸   XM_008765111
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008763332   ⟸   XM_008765110
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008763338   ⟸   XM_008765116
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017450397   ⟸   XM_017594908
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000074120   ⟸   ENSRNOT00000084144
RefSeq Acc Id: XP_038935314   ⟸   XM_039079386
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038935312   ⟸   XM_039079384
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038935315   ⟸   XM_039079387
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038935316   ⟸   XM_039079388
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038935313   ⟸   XM_039079385
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038935317   ⟸   XM_039079389
- Peptide Label: isoform X12
RefSeq Acc Id: ENSRNOP00000089491   ⟸   ENSRNOT00000097476
RefSeq Acc Id: ENSRNOP00000081849   ⟸   ENSRNOT00000109298
RefSeq Acc Id: ENSRNOP00000087622   ⟸   ENSRNOT00000100592
Protein Domains
PA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQL3-F1-model_v2 AlphaFold Q5PQL3 1-577 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694999
Promoter ID:EPDNEW_R5523
Type:multiple initiation site
Name:Sppl2b_1
Description:signal peptide peptidase-like 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,724,860 - 11,724,920EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308556 AgrOrtholog
BioCyc Gene G2FUF-34974 BioCyc
Ensembl Genes ENSRNOG00000057881 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074120 ENTREZGENE
  ENSRNOP00000074120.2 UniProtKB/TrEMBL
  ENSRNOP00000081849 ENTREZGENE
  ENSRNOP00000081849.1 UniProtKB/TrEMBL
  ENSRNOP00000087622.1 UniProtKB/TrEMBL
  ENSRNOP00000089491.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084144 ENTREZGENE
  ENSRNOT00000084144.2 UniProtKB/TrEMBL
  ENSRNOT00000097476 ENTREZGENE
  ENSRNOT00000097476.1 UniProtKB/TrEMBL
  ENSRNOT00000100592.1 UniProtKB/TrEMBL
  ENSRNOT00000109298 ENTREZGENE
  ENSRNOT00000109298.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121303 IMAGE-MGC_LOAD
InterPro PA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_A22B_SPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Preselin/SPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPPL2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362828 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95005 IMAGE-MGC_LOAD
NCBI Gene 362828 ENTREZGENE
PANTHER PTHR12174 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12174:SF39 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_A22B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF02225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sppl2b PhenoGen
SMART PSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZVS2_RAT UniProtKB/TrEMBL
  A0A8I6A7E0_RAT UniProtKB/TrEMBL
  A0A8I6GG67_RAT UniProtKB/TrEMBL
  A0A8L2R960_RAT UniProtKB/TrEMBL
  Q5PQL3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Sppl2b  signal peptide peptidase-like 2B  RGD1308556  similar to SPPL2b; presenilin-like protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1308556  similar to SPPL2b; presenilin-like protein 1  RGD1308556_predicted  similar to SPPL2b; presenilin-like protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308556_predicted  similar to SPPL2b; presenilin-like protein 1 (predicted)  LOC362828_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362828_predicted  similar to SPPL2b; presenilin-like protein 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL