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ONTOLOGY REPORT - ANNOTATIONS

Term:norepinephrine biosynthetic process
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Accession:GO:0042421 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
Synonyms:exact_synonym: levarterenol biosynthesis;   levarterenol biosynthetic process;   noradrenaline biosynthesis;   noradrenaline biosynthetic process;   norepinephrine anabolism;   norepinephrine biosynthesis;   norepinephrine formation;   norepinephrine synthesis


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norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:4405722)
(PMID:4858102)		 MGI PMID:4405722 PMID:4858102 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,991...62,110,048 		JBrowse link
G DBH dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:10051631), (PMID:9603211) RGD
UniProt
Ensembl
GO_Central
TreeGrafter
MGI		 PMID:9603211 PMID:10051631 PMID:10573542 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 RGD:1625403 NCBI chr 1:273,204,407...273,225,562
Ensembl chr 1:273,204,175...273,225,552 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr 3:94,167,759...94,253,662
Ensembl chr 3:94,165,816...94,254,079 		JBrowse link
G GATA3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISS
ISO		 (PMID:10835639) Ensembl
UniProt
MGI		 PMID:10835639 GO_REF:0000024 GO_REF:0000107 NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,663...63,388,859 		JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (MGI:4413411|PMID:19008477) Ensembl
BHF-UCL		 PMID:19008477 GO_REF:0000107 MGI:4413411 NCBI chr14:16,460,089...16,462,979
Ensembl chr14:16,459,971...16,462,207 		JBrowse link
G INSM1 INSM transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:28,379,529...28,382,554
Ensembl chr17:28,379,880...28,381,427 		JBrowse link
G KL klotho ISO RGD PMID:20086041 RGD:10403068 NCBI chr11:9,427,236...9,479,251
Ensembl chr11:9,427,037...9,479,228 		JBrowse link
G MOXD1 monooxygenase DBH like 1 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:31,282,491...31,367,589
Ensembl chr 1:31,282,506...31,367,779 		JBrowse link
G MOXD2 monooxygenase DBH like 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr18:7,742,254...7,751,098 JBrowse link
G TH tyrosine hydroxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:1,499,628...1,506,180
Ensembl chr 2:1,499,620...1,506,170 		JBrowse link
Term paths to the root
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  biological_process 17806
    metabolic process 10375
      organic substance metabolic process 9948
        organonitrogen compound metabolic process 5044
          amine metabolic process 128
            biogenic amine metabolic process 108
              catecholamine metabolic process 65
                norepinephrine metabolic process 21
                  norepinephrine biosynthetic process 10
paths to the root