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ONTOLOGY REPORT - ANNOTATIONS


Term:norepinephrine metabolic process
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Accession:GO:0042415 term browser browse the term
Definition:The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
Synonyms:exact_synonym: levarterenol metabolic process;   levarterenol metabolism;   noradrenaline metabolic process;   noradrenaline metabolism;   norepinephrine metabolism


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norepinephrine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B IDA RGD PMID:10424772 RGD:8548769 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Atp7a ATPase copper transporting alpha ISO MGI:MGI:1856102|MGI:MGI:1856466 (MGI:MGI:53851|PMID:4147174) RGD PMID:4147174 MGI:MGI:53851, MGI:MGI:71923 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO
IEA
MGI:MGI:1861921 (MGI:MGI:1313089|PMID:9808618)
GO_REF:0000107
RGD
Ensembl
PMID:9808618 GO_REF:0000107, MGI:MGI:1313089 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Ly6e lymphocyte antigen 6 family member E ISO MGI:MGI:2429638 (MGI:MGI:2157257|PMID:11784869) RGD PMID:11784869 MGI:MGI:2157257 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase IDA RGD PMID:3945626 RGD:5130757 NCBI chr10:86,340,893...86,342,501
Ensembl chr10:86,340,940...86,342,858
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO MGI:MGI:3050230 (MGI:MGI:3047192|PMID:15249681) RGD PMID:15249681 MGI:MGI:3047192 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rnf180 ring finger protein 180 ISO
IBA
(MGI:MGI:5505713|PMID:23926250)
PMID:21873635
RGD PMID:23926250, PMID:21873635 MGI:MGI:5505713, RGD:13792537 NCBI chr 2:35,718,100...35,892,578
Ensembl chr 2:35,718,889...35,870,578
JBrowse link
G Rtl4 retrotransposon Gag like 4 ISO MGI:MGI:5789261 (MGI:MGI:5749620|PMID:26402067) RGD PMID:26402067 MGI:MGI:5749620 NCBI chr  X:115,908,999...116,402,406
Ensembl chr  X:116,399,611...116,400,516
JBrowse link
G Spr sepiapterin reductase ISO MGI:MGI:3757641 (MGI:MGI:3722569|PMID:16532389) RGD PMID:16532389 MGI:MGI:3722569 NCBI chr 4:116,912,343...116,916,073
Ensembl chr 4:116,912,351...116,916,236
JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha ISO MGI:MGI:1856097|MGI:MGI:1856098 (MGI:MGI:53801|PMID:4405722), (MGI:MGI:53940|PMID:4858102) RGD PMID:4405722, PMID:4858102 MGI:MGI:53801, MGI:MGI:53940 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Dbh dopamine beta-hydroxylase TAS
IBA
ISO
ISS
IEA
IMP
PMID:21873635
MGI:MGI:1857556 (MGI:MGI:1203930|PMID:9603211), (MGI:MGI:1332340|PMID:10051631), (MGI:MGI:5787847|PMID:27148966), (MGI:MGI:72180|PMID:7715704)
GO_REF:0000024
(PMID:27148966)
GO_REF:0000041
RGD
UniProt
PMID:7715704, PMID:9603211, PMID:10051631, PMID:27148966, PMID:11914591, PMID:21873635, PMID:10573542 GO_REF:0000024, GO_REF:0000041, MGI:MGI:1203930, MGI:MGI:1332340, MGI:MGI:5787847, MGI:MGI:72180, RGD:727567, RGD:13792537, RGD:1625403 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Gata3 GATA binding protein 3 ISO
ISS
MGI:MGI:2153826 (MGI:MGI:1859081|PMID:10835639)
GO_REF:0000024
RGD
UniProt
PMID:10835639 GO_REF:0000024, MGI:MGI:1859081 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Insm1 INSM transcriptional repressor 1 ISO (MGI:MGI:3772428|PMID:18094025) RGD PMID:18094025 MGI:MGI:3772428 NCBI chr 3:140,427,961...140,430,467 JBrowse link
G Kl Klotho IMP RGD PMID:20086041 RGD:10403068 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Moxd1 monooxygenase, DBH-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:22,124,498...22,206,565
Ensembl chr 1:22,124,495...22,206,505
JBrowse link
G Moxd2 monooxygenase, DBH-like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:69,117,477...69,125,972
Ensembl chr 4:69,117,477...69,125,972
JBrowse link
G Th tyrosine hydroxylase ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hand2 heart and neural crest derivatives expressed 2 ISO
IEA
(MGI:MGI:4413411|PMID:19008477)
GO_REF:0000107
RGD
Ensembl
PMID:19008477 GO_REF:0000107, MGI:MGI:4413411 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      nitrogen compound metabolic process 10342
        organonitrogen compound metabolic process 7132
          catecholamine metabolic process 59
            norepinephrine metabolic process 17
              norepinephrine biosynthetic process + 10
              norepinephrine catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        cellular aromatic compound metabolic process 5708
          phenol-containing compound metabolic process 123
            catechol-containing compound metabolic process 59
              catecholamine metabolic process 59
                norepinephrine metabolic process 17
                  norepinephrine biosynthetic process + 10
                  norepinephrine catabolic process 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.