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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:granulocyte-macrophage colony-stimulating factor signaling pathway
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Accession:GO:0038157 term browser browse the term
Definition:The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors.
Synonyms:exact_synonym: CSF2 signaling pathway;   GM-CSF receptor signaling pathway;   GM-CSF signaling pathway;   granulocyte-macrophage colony-stimulating factor receptor signaling pathway
 related_synonym: granulocyte-macrophage colony-stimulating factor signalling pathway


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granulocyte-macrophage colony-stimulating factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 involved_in ISO (PMID:18692472) RGD PMID:18692472 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha involved_in ISO (PMID:18692472) RGD PMID:18692472 NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta involved_in ISO (PMID:18692472) RGD PMID:18692472 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISO (PMID:18692472) RGD PMID:18692472 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    cellular process 18196
      signal transduction 7020
        cell surface receptor signaling pathway 2814
          cytokine-mediated signaling pathway 484
            granulocyte-macrophage colony-stimulating factor signaling pathway 4
Path 2
Term Annotations click to browse term
  biological_process 19694
    biological regulation 13309
      regulation of biological process 12906
        regulation of cellular process 12363
          signal transduction 7020
            cell surface receptor signaling pathway 2814
              cytokine-mediated signaling pathway 484
                granulocyte-macrophage colony-stimulating factor signaling pathway 4
paths to the root