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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:ERBB4-ERBB4 signaling pathway
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Accession:GO:0038138 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: ERBB4 homodimeric signaling pathway;   ERBB4-ERBB4 signalling pathway;   HER4-HER4 signaling pathway


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ERBB4-ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTC betacellulin involved_in ISO (PMID:9168114) MGI PMID:9168114 NCBI chr15:64,133,051...64,159,155
Ensembl chr15:64,135,920...64,158,970 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:19,029,647...20,134,576
Ensembl chr37:19,037,217...20,134,426 		JBrowse link
G EREG epiregulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:62,857,325...62,877,831
Ensembl chr13:62,856,709...62,877,760 		JBrowse link
G NRG1 neuregulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:31,697,958...32,771,888
Ensembl chr16:31,706,851...32,771,932 		JBrowse link
G NRG2 neuregulin 2 involved_in ISO (PMID:9168115) MGI PMID:9168115 NCBI chr 2:35,085,192...35,264,509
Ensembl chr 2:35,085,361...35,264,378 		JBrowse link
G NRG3 neuregulin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:30,515,845...31,557,598
Ensembl chr 4:30,515,890...31,556,152 		JBrowse link
G NRG4 neuregulin 4 involved_in ISO (PMID:12466964) MGI PMID:12466964 NCBI chr29:7,478,483...7,483,875 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17925
    cellular process 16910
      signal transduction 6317
        cell surface receptor signaling pathway 2807
          enzyme-linked receptor protein signaling pathway 1041
            cell surface receptor protein tyrosine kinase signaling pathway 654
              ERBB signaling pathway 132
                ERBB4 signaling pathway 11
                  ERBB4-ERBB4 signaling pathway 7
Path 2
Term Annotations click to browse term
  biological_process 17925
    biological regulation 12446
      regulation of biological process 12082
        signaling 6866
          signal transduction 6317
            cell surface receptor signaling pathway 2807
              enzyme-linked receptor protein signaling pathway 1041
                cell surface receptor protein tyrosine kinase signaling pathway 654
                  ERBB signaling pathway 132
                    ERBB4 signaling pathway 11
                      ERBB4-ERBB4 signaling pathway 7
paths to the root